How much additional muscle growth can a natty expect from MGF?

[oceanus99]

I'm hearing lots of conflicting advice on peptides in general, muscle growth wise. Some say they don't offer any muscle growth others say they do. Would Mechano Growth Factor cause additional increase in muscle mass for a natural lifter?

[Curt James]

For those unfamiliar with MGF (uh, me)...

Mechano growth factor (MGF) is a novel splice variant of the Insulin-Like Growth Factor-1 (IGF-1), also known as IGF-1 Ec in humans and IGF-1Eb in rodents. It is actually originally called MGF because the RNA form of it is expressed in muscle tissues in response to the overload or/and damage of muscle growth tissue. The C-terminal peptide of the mechano growth factor (MGF) is a crucial region for the alternative splicing of the peptide. The alternative splicing in the MGF is brought about by the shift in the reading frame in which a specific C-terminal sequence (E-domain) is encoded by exon 5 and the first part of the exon 6. Another interesting point in MGF is that, because of the E domain it contains, MGF can act on muscles independently from the rest of the molecule. Furthermore, MGF can elicit very different effects with mGF promoting satellite cells proliferation and IGF-1 inducing differentiation (Dluzniewska et al. 2005).

[supbro!]

1.5 to 150 pounds of lean muscle all depending on your birth sign.