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08-02-2009, 12:08 PM
Exp Biol Med (Maywood). (javascript:AL_get(this, 'jour', 'Exp Biol Med (Maywood).');) 2009 Jul 13. [Epub ahead of print]http://www.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--highwire.stanford.edu-icons-externalservices-pubmed-standard-psebm_full.gif (http://forums.rxmuscle.com/entrez/utils/fref.fcgi?PrId=3051&itool=AbstractPlus-def&uid=19596833&db=pubmed&url=http://www.ebmonline.org/cgi/pmidlookup?view=long&pmid=19596833) Links (javascript:PopUpMenu2_Set(Menu19596833);)
Folic Acid Supplementation Modifies {beta}-Adrenoceptor-Mediated in vitro Lipolysis of the Obese/Diabetic (+db/+db) Mice.
Lam TY (http://forums.rxmuscle.com/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Lam%20TY%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsP anel.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus), Seto SW (http://forums.rxmuscle.com/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Seto%20SW%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsP anel.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus), Au AL (http://forums.rxmuscle.com/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Au%20AL%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsP anel.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus), Poon CC (http://forums.rxmuscle.com/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Poon%20CC%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsP anel.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus), Lam AH (http://forums.rxmuscle.com/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Lam%20AH%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsP anel.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus), Lau MW (http://forums.rxmuscle.com/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Lau%20MW%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsP anel.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus), Chan SW (http://forums.rxmuscle.com/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Chan%20SW%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsP anel.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus), Ngai SM (http://forums.rxmuscle.com/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Ngai%20SM%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsP anel.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus), Leung GP (http://forums.rxmuscle.com/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Leung%20GP%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsP anel.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus), Lee SM (http://forums.rxmuscle.com/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Lee%20SM%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsP anel.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus), Tsui SK (http://forums.rxmuscle.com/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Tsui%20SK%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsP anel.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus), Kwan YW (http://forums.rxmuscle.com/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Kwan%20YW%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsP anel.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus).
The Chinese University of Hong Kong.
The effects of folic acid (5.7 and 71 microg/kg), 4 weeks) consumption on the beta-adrenoceptors (beta-ARs)-elicited lipolysis in vitro of the abdominal adipocytes of the lean/control (+m/+db) and obese/diabetic (+db/+db) mice (female) were investigated. beta-AR agonists (salbutamol, a beta2-AR agonist; BRL 37344 and CGP 12177, beta3-AR agonists; adrenaline, a beta-AR agonist)-mediated lipolysis, beta2 and beta3-ARs protein expression of the adipose tissues after folic acid consumption were evaluated. Our results demonstrate that a smaller magnitude of the basal (spontaneous) and the beta-AR agonists-triggered lipolysis was observed in +db/+db mice, and folic acid supplementation (71 microg/kg) resulted in an improvement of both the baseline and the beta-ARs-mediated lipolysis. In controls, a lower beta2 and beta3-ARs protein expression of the adipose tissues was detected in +db/+db mice, compared to +m/+db mice. In both strains fed with folic acid (71 microg/kg), a reduction of beta2-AR protein expression was observed compared to the respective controls. In +db/+db mice, folic acid (5.7 and 71 microg/kg) consumption caused a dose-dependent increase of beta3-AR protein expression compared to controls. We demonstrate that lipolysis elicited by beta-AR (beta2- and beta3-ARs) agonists was blunted in +db/+db mice. Folic acid consumption has significant modulatory effects on beta-ARs protein expression and lipolysis.
Folic Acid Supplementation Modifies {beta}-Adrenoceptor-Mediated in vitro Lipolysis of the Obese/Diabetic (+db/+db) Mice.
Lam TY (http://forums.rxmuscle.com/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Lam%20TY%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsP anel.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus), Seto SW (http://forums.rxmuscle.com/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Seto%20SW%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsP anel.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus), Au AL (http://forums.rxmuscle.com/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Au%20AL%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsP anel.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus), Poon CC (http://forums.rxmuscle.com/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Poon%20CC%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsP anel.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus), Lam AH (http://forums.rxmuscle.com/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Lam%20AH%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsP anel.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus), Lau MW (http://forums.rxmuscle.com/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Lau%20MW%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsP anel.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus), Chan SW (http://forums.rxmuscle.com/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Chan%20SW%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsP anel.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus), Ngai SM (http://forums.rxmuscle.com/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Ngai%20SM%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsP anel.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus), Leung GP (http://forums.rxmuscle.com/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Leung%20GP%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsP anel.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus), Lee SM (http://forums.rxmuscle.com/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Lee%20SM%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsP anel.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus), Tsui SK (http://forums.rxmuscle.com/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Tsui%20SK%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsP anel.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus), Kwan YW (http://forums.rxmuscle.com/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Kwan%20YW%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsP anel.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus).
The Chinese University of Hong Kong.
The effects of folic acid (5.7 and 71 microg/kg), 4 weeks) consumption on the beta-adrenoceptors (beta-ARs)-elicited lipolysis in vitro of the abdominal adipocytes of the lean/control (+m/+db) and obese/diabetic (+db/+db) mice (female) were investigated. beta-AR agonists (salbutamol, a beta2-AR agonist; BRL 37344 and CGP 12177, beta3-AR agonists; adrenaline, a beta-AR agonist)-mediated lipolysis, beta2 and beta3-ARs protein expression of the adipose tissues after folic acid consumption were evaluated. Our results demonstrate that a smaller magnitude of the basal (spontaneous) and the beta-AR agonists-triggered lipolysis was observed in +db/+db mice, and folic acid supplementation (71 microg/kg) resulted in an improvement of both the baseline and the beta-ARs-mediated lipolysis. In controls, a lower beta2 and beta3-ARs protein expression of the adipose tissues was detected in +db/+db mice, compared to +m/+db mice. In both strains fed with folic acid (71 microg/kg), a reduction of beta2-AR protein expression was observed compared to the respective controls. In +db/+db mice, folic acid (5.7 and 71 microg/kg) consumption caused a dose-dependent increase of beta3-AR protein expression compared to controls. We demonstrate that lipolysis elicited by beta-AR (beta2- and beta3-ARs) agonists was blunted in +db/+db mice. Folic acid consumption has significant modulatory effects on beta-ARs protein expression and lipolysis.