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Frosty
08-07-2009, 03:34 PM
What is the necessary minimum dosing for green tea extract for body composition changes? Preferably what the EGCG dose required is, but is EGCG the only component involved in body composition changes?

TPT
08-08-2009, 03:05 PM
the literature base on egcg is damn strong, espeically using animal models. In human subjects, three optimistic tracks of research are apprarent: the effects of catechins on reducing fat, increasing glucose tolerance, and improving cardiovasular measures.

no optimal dose has been established yet. however, in attempt to apply the results from "positive" studies one would recommend a range of 100 mg/day to 540 mg/day for up to 13 weeks for reducing body fat.

it seems as if the study of egcg dosages continually rise. the studies this year have shown good effects on fat reduction with dosages a bit higher ranging from 600 to 800 mg/day.

Frosty
08-08-2009, 03:14 PM
So for a good extract that sounds like 1-3 500mg caps? Is there a significant difference between these doses? Is the effect dose-dependent or is there a point of diminishing returns with realistic doses? Or perhaps even a bell-shaped dose response curve?

TPT
08-08-2009, 03:47 PM
So for a good extract that sounds like 1-3 500mg caps? Is there a significant difference between these doses? Is the effect dose-dependent or is there a point of diminishing returns with realistic doses? Or perhaps even a bell-shaped dose response curve?


yeah, those doses sound just about right.

the data does not show clear differences between doses or simply cannot be interpreted though the literature yet. i would go with the higher end towards 800 mg/day until the literature shows different.

ill try and find a paper to post.

Frosty
08-08-2009, 03:49 PM
Are there any side effects to these huge doses? That's equivalent to an enormous amount of actual green tea so it makes me wonder.

TPT
08-08-2009, 03:58 PM
Are there any side effects to these huge doses? That's equivalent to an enormous amount of actual green tea so it makes me wonder.


that is the crazy shiz. green tea is cheap and safe. and its only up to about 20 cups per day if you wanna drink it. lol. http://clincancerres.aacrjournals.org/cgi/content/full/9/9/3312

here is a great review paper out this year youll love that speaks alittle about the effects of green tea on sugar tolerance and other outcomes.
http://www.naturallygorgeous.tv/Green_tea_prevention.pdf

Frosty
08-08-2009, 04:06 PM
Did I read that correctly that green tea actually up-regulates GLUT-4 in muscle while lowering GLUT-4 in adipose??? All the while reducing adipocyte growth and differentiation??

This seems like an awfully good property to have for mass gaining diets....

TPT
08-08-2009, 04:07 PM
Clinical Trials

Pharmacokinetics and Safety of Green Tea Polyphenols after Multiple-Dose Administration of Epigallocatechin Gallate and Polyphenon E in Healthy Individuals1

H-H. Sherry Chow2, Yan Cai, Iman A. Hakim, James A. Crowell, Farah Shahi, Chris A. Brooks, Robert T. Dorr, Yukihiko Hara and David S. Alberts

Arizona Cancer Center, The University of Arizona, Tucson, Arizona 85724 [H-H. S. C., Y. C., I. A. H., F. S., C. A. B., R. T. D., D. S. A.]; College of Pharmacy, The University of Arizona, Tucson, Arizona 85721 [H-H. S. C., Y. C.]; Division of Cancer Prevention, National Cancer Institute, Bethesda, Maryland 20892 [J. A. C.]; and Mitsui Norin Co., Ltd., Shizuoka 426-01, Japan [Y. H.]


Purpose: Green tea and green tea polyphenols have been shown to possess cancer preventive activities in preclinical model systems. In preparation for future green tea intervention trials, we have conducted a clinical study to determine the safety and pharmacokinetics of green tea polyphenols after 4 weeks of daily p.o. administration of epigallocatechin gallate (EGCG) or Polyphenon E (a defined, decaffeinated green tea polyphenol mixture). In an exploratory fashion, we have also determined the effect of chronic green tea polyphenol administration on UV-induced erythema response.

Experimental Design: Healthy participants with Fitzpatric skin type II or III underwent a 2-week run-in period and were randomly assigned to receive one of the five treatments for 4 weeks: 800 mg EGCG once/day, 400 mg EGCG twice/day, 800 mg EGCG as Polyphenon E once/day, 400 mg EGCG as Polyphenon E twice/day, or a placebo once/day (8 subjects/group). Samples were collected and measurements performed before and after the 4-week treatment period for determination of safety, pharmacokinetics, and biological activity of green tea polyphenol treatment.
Results: Adverse events reported during the 4-week treatment period include excess gas, upset stomach, nausea, heartburn, stomach ache, abdominal pain, dizziness, headache, and muscle pain. All of the reported events were rated as mild events. For most events, the incidence reported in the polyphenol-treated groups was not more than that reported in the placebo group. No significant changes were observed in blood counts and blood chemistry profiles after repeated administration of green tea polyphenol products. There was a >60% increase in the area under the plasma EGCG concentration-time curve after 4 weeks of green tea polyphenol treatment at a dosing schedule of 800 mg once daily. No significant changes were observed in the pharmacokinetics of EGCG after repeated green tea polyphenol treatment at a regimen of 400 mg twice daily. The pharmacokinetics of the conjugated metabolites of epigallocatechin and epicatechin were not affected by repeated green tea polyphenol treatment. Four weeks of green tea polyphenol treatment at the selected dose and dosing schedule did not provide protection against UV-induced erythema.

Conclusions: We conclude that it is safe for healthy individuals to take green tea polyphenol products in amounts equivalent to the EGCG content in 816 cups of green tea once a day or in divided doses twice a day for 4 weeks. There is a >60% increase in the systemic availability of free EGCG after chronic green tea polyphenol administration at a high daily bolus dose (800 mg EGCG or Polyphenon E once daily).

TPT
08-08-2009, 04:13 PM
Did I read that correctly that green tea actually up-regulates GLUT-4 in muscle while lowering GLUT-4 in adipose??? All the while reducing adipocyte growth and differentiation??

This seems like an awfully good property to have for mass gaining diets....


yeah, crazy right. the animal models provide us with those mechanisms. still we should use some discretion generalizing them to humans.

BigBilly
09-20-2009, 12:11 PM
what about taking a 2liter water bottle and rip open 2 green tea and drink and eat the leafs

TPT
10-13-2009, 06:29 PM
what about taking a 2liter water bottle and rip open 2 green tea and drink and eat the leafs


sounds good.

TPT
10-13-2009, 06:32 PM
here is more evidence of the fat-burning effects of green tea.

i have been trying to consistently have some green tea daily.


http://jn.nutrition.org/cgi/content/abstract/139/2/264


Nutrition and Disease
Green Tea Catechin Consumption Enhances Exercise-Induced Abdominal Fat Loss in Overweight and Obese Adults1,2

Kevin C. Maki3,*, Matthew S. Reeves3, Mildred Farmer4, Koichi Yasunaga5, Noboru Matsuo5, Yoshihisa Katsuragi5, Masanori Komikado5, Ichiro Tokimitsu5, Donna Wilder3, Franz Jones3, Jeffrey B. Blumberg6 and Yolanda Cartwright3


3 Provident Clinical Research, Bloomington, IN 47403 and Glen Ellyn, IL 60137; 4 Meridien Research, St Petersburg, FL 33709; 5 Health Care Food Research Laboratory, Kao Corporation, 131-8501 Tokyo, Japan; and 6 Antioxidants Research Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111
This study evaluated the influence of a green tea catechin beverage on body composition and fat distribution in overweight and obese adults during exercise-induced weight loss. Participants (n = 132 with 107 completers) were randomly assigned to receive a beverage containing http://jn.nutrition.org/emath/sim.gif625 mg of catechins with 39 mg caffeine or a control beverage (39 mg caffeine, no catechins) for 12 wk. Participants were asked to maintain constant energy intake and engage in http://jn.nutrition.org/emath/ge.gif180 min/wk moderate intensity exercise, including http://jn.nutrition.org/emath/ge.gif3 supervised sessions per week. Body composition (dual X-ray absorptiometry), abdominal fat areas (computed tomography), and clinical laboratory tests were measured at baseline and wk 12. There was a trend (P = 0.079) toward greater loss of body weight in the catechin group compared with the control group; least squares mean (95% CI) changes, adjusted for baseline value, age, and sex, were 2.2 (3.1, 1.3) and 1.0 (1.9, 0.1) kg, respectively. Percentage changes in fat mass did not differ between the catechin [5.2 (7.0, 3.4)] and control groups [3.5 (5.4, 1.6)] (P = 0.208). However, percentage changes in total abdominal fat area [7.7 (11.7, 3.8) vs. 0.3 (4.4, 3.9); P = 0.013], subcutaneous abdominal fat area [6.2 (10.2, 2.2) vs. 0.8 (3.3, 4.9); P = 0.019], and fasting serum triglycerides (TG) [11.2 (18.8, 3.6) vs. 1.9 (5.9, 9.7); P = 0.023] were greater in the catechin group. These findings suggest that green tea catechin consumption enhances exercise-induced changes in abdominal fat and serum TG.