Pramipexole

[SallyAnne]

I've been reading the Anafit forums and there is a lot of discussion on Pramipexole. http://www.afboard.com/forum/womens-discussion/30612-pramipexole-feedback.html

Not only is it being touted as a great prolactin antagonist - but women (and Ulter/Macro) are reporting fat loss and seriously elevated GH levels.

Anyone have experience with this drug? It's prescribed by doctors for Restless Leg Syndrome as well as depression...

[SallyAnne]

bump - no one has experience with this?

[heavyiron]

No experience with it but I have read similar reports. I am thinking of trying it myself.

[The Big Sexy]

I think a guy I know took this and he said his gyno lumps disappeared in about 5 days on it.

[SallyAnne]

I've been reading on bb forums that it helps with weight loss, but when I read regular reviews of the drug off Rx websites, people complain of weight gain...

[SallyAnne]

I think a guy I know took this and he said his gyno lumps disappeared in about 5 days on it.

I've read that, too - it reverses gyno. That would be amazing.

[The Big Sexy]

I've read that, too - it reverses gyno. That would be amazing.

Yeah - I was surprised to read that... but the guy I know is uber sensitive to test or anabolics of any kind... no matter what kind of anti-e's he takes he gets worse gyno... so, it was really a God-send for him.

[Carson]

My experience was nothing to write home about. I used it at .5mg ED for several weeks. There was no reduction in gyno, but it did put me to sleep, and a deep sleep at that. So there might have been a positive affect on HGH production.

[SallyAnne]

Ok - I wanted to update you guys on this drug. My fiance has been taking it and it has reversed about 50% of his gyno so far. He's also telling me he sleeps like a baby and his mood has greatly improved. He was so excited about the gyno thing - he was planning on going in for surgery to have it removed, but is going to wait to see how much the prami reverses.

He's taking 1mg Every night, or four .25 tablets. He tried splitting them up morning and night, but he says it makes him very tired if he takes any in the morning.

[heavyiron]

Ok - I wanted to update you guys on this drug. My fiance has been taking it and it has reversed about 50% of his gyno so far. He's also telling me he sleeps like a baby and his mood has greatly improved. He was so excited about the gyno thing - he was planning on going in for surgery to have it removed, but is going to wait to see how much the prami reverses.

He's taking 1mg Every night, or four .25 tablets. He tried splitting them up morning and night, but he says it makes him very tired if he takes any in the morning.


Any side effects at all?

[SallyAnne]

Any side effects at all?

He says no.

I looked at the side effects on the mayo clinic website and the most common are insomnia, headaches, runny nose, constipation, dry mouth, & weight loss.

[zubbeyboy]

There was a guy on promuscle message boards that almost died from it. Do your research.This shit is given to Parkinsons disease patients. Not nothing to be taken lightly. I dont have a good feeling about it and have researched it quite a bit. My advice? Stay away

[heavyiron]

He says no.

I looked at the side effects on the mayo clinic website and the most common are insomnia, headaches, runny nose, constipation, dry mouth, & weight loss.
Glad he has no sides.

Insomnia??? that's weird, I have heard numerous reports of it helping sleep. Maybe it is dose dependant.

[zubbeyboy]

Sleep from people i know was on it was not a problem. They had like crazy ass dreams. No like REAL crazy.

[heavyiron]

Lots of sex and gambling when you use it.

Frequency of new-onset pathologic compulsive gambling or hypersexuality after drug treatment of idiopathic Parkinson disease.

Bostwick JM (http://forums.rxmuscle.com/pubmed?term=%22Bostwick%20JM%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsP anel.Pubmed_RVAbstract), Hecksel KA (http://forums.rxmuscle.com/pubmed?term=%22Hecksel%20KA%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsP anel.Pubmed_RVAbstract), Stevens SR (http://forums.rxmuscle.com/pubmed?term=%22Stevens%20SR%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsP anel.Pubmed_RVAbstract), Bower JH (http://forums.rxmuscle.com/pubmed?term=%22Bower%20JH%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsP anel.Pubmed_RVAbstract), Ahlskog JE (http://forums.rxmuscle.com/pubmed?term=%22Ahlskog%20JE%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsP anel.Pubmed_RVAbstract).
Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN 55905, USA. [email protected]


Comment in:

Mayo Clin Proc. 2009 Sep;84(9):846-7; author reply 847. (http://forums.rxmuscle.com/pubmed/19720785?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed _ResultsPanel.Pubmed_RVAbstract)

OBJECTIVE: To determine the frequency of new-onset compulsive gambling or hypersexuality among regional patients with Parkinson disease (PD), ascertaining the relationship of these behaviors to PD drug use. PATIENTS AND METHODS: We retrospectively reviewed the medical records of patients from 7 rural southeastern Minnesota counties who had at least 1 neurology appointment for PD between July 1, 2004, and June 30, 2006. The main outcome measure was compulsive gambling or hypersexuality developing after parkinsonism onset, including the temporal relationship to PD drug use. RESULTS: Of 267 patients with PD who met the study inclusion criteria, new-onset gambling or hypersexuality was documented in 7 (2.6%). All were among the 66 patients (10.6%) taking a dopamine agonist. Moreover, all 7 (18.4%) were among 38 patients taking therapeutic doses (defined as >/=2 mg of pramipexole or 6 mg of ropinirole daily). Behaviors were clearly pathologic and disabling in 5: 7.6% of all patients taking an agonist and 13.2% of those taking therapeutic doses. Of the 5 patients, 2 had extensive treatment for what was considered a primary psychiatric problem before the agonist connection was recognized. CONCLUSION: Among the study patients with PD, new-onset compulsive gambling or hypersexuality was documented in 7 (18.4%) of 38 patients taking therapeutic doses of dopamine agonists but was not found among untreated patients, those taking subtherapeutic agonist doses, or those taking carbidopa/levodopa alone. Behaviors abated with discontinuation of agonist therapy or dose reduction. Because this is a retrospective study, cases may have been missed, and hence this study may reflect an underestimation of the true frequency. Physicians who care for patients taking these drugs should recognize the drug's potential to induce pathologic syndromes that sometimes masquerade as primary psychiatric disease.

PMID: 19339647 [PubMed - indexed for MEDLINE]

[heavyiron]

Association of dopamine agonist use with impulse control disorders in Parkinson disease.

Weintraub D (http://forums.rxmuscle.com/pubmed?term=%22Weintraub%20D%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsP anel.Pubmed_RVAbstract), Siderowf AD (http://forums.rxmuscle.com/pubmed?term=%22Siderowf%20AD%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsP anel.Pubmed_RVAbstract), Potenza MN (http://forums.rxmuscle.com/pubmed?term=%22Potenza%20MN%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsP anel.Pubmed_RVAbstract), Goveas J (http://forums.rxmuscle.com/pubmed?term=%22Goveas%20J%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsP anel.Pubmed_RVAbstract), Morales KH (http://forums.rxmuscle.com/pubmed?term=%22Morales%20KH%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsP anel.Pubmed_RVAbstract), Duda JE (http://forums.rxmuscle.com/pubmed?term=%22Duda%20JE%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsP anel.Pubmed_RVAbstract), Moberg PJ (http://forums.rxmuscle.com/pubmed?term=%22Moberg%20PJ%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsP anel.Pubmed_RVAbstract), Stern MB (http://forums.rxmuscle.com/pubmed?term=%22Stern%20MB%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsP anel.Pubmed_RVAbstract).
Department of Psychiatry, University of Pennsylvania, and Parkinson's Disease Research, Education, and Clinical Center, USA.
OBJECTIVE: To determine the frequency and correlates of impulse control disorders (ICDs) in Parkinson disease (PD). DESIGN: An unstructured screening interview for ICDs (compulsive gambling, buying, and sexual behavior) followed by a telephone-administered structured interview for screen-positive patients. SETTING: Two university-affiliated movement disorders centers. PARTICIPANTS: A convenience sample of 272 patients with idiopathic PD who were screened for psychiatric complications. MAIN OUTCOME MEASURES: Presence of compulsive gambling, buying, or sexual behavior as assessed by the Minnesota Impulsive Disorders Interview. RESULTS: Eighteen patients (6.6%) with PD met criteria for an ICD at some point during the course of PD, including 11 (4.0%) with an active ICD. Compulsive gambling and compulsive sexual behavior were equally common. In a multivariate model, treatment with a dopamine agonist (P = .01) and a history of ICD symptoms prior to PD onset (P = .02) predicted current ICD. There were no differences between the dopamine agonists in their association with ICDs (P = .21), and daily doses of dopamine agonists were higher in patients with an ICD than in dopamine agonist-treated patients without an ICD (P < .001). CONCLUSIONS: Patients with PD treated with a dopamine agonist should be made aware of the risk of developing an ICD and monitored clinically. Because dopamine agonists are increasingly being used for other indications, future research should assess the dopamine agonist-associated risk for ICDs in other populations.

PMID: 16831966 [PubMed - indexed for MEDLINE]

[heavyiron]

Increased frequency and range of sexual behavior in a patient with Parkinson's disease after use of pramipexole: a case report.

Munhoz RP (http://forums.rxmuscle.com/pubmed?term=%22Munhoz%20RP%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsP anel.Pubmed_RVAbstract), Fabiani G (http://forums.rxmuscle.com/pubmed?term=%22Fabiani%20G%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsP anel.Pubmed_RVAbstract), Becker N (http://forums.rxmuscle.com/pubmed?term=%22Becker%20N%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsP anel.Pubmed_RVAbstract), Teive HA (http://forums.rxmuscle.com/pubmed?term=%22Teive%20HA%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsP anel.Pubmed_RVAbstract).
Movement Disorders Unit, Neurology Service, Hospital de Clínicas, Federal University of Paraná, Curitiba, Brazil.
INTRODUCTION: Several recent reports have linked the use of dopamine agonists (DAs) to a variety of compulsive behaviors in patients with Parkinson's disease (PD). These inappropriate behaviors may include pathological gambling, compulsive shopping, and hypersexuality. AIM: To report the case of a patient with increased range of sexual behavior after use of pramipexole, a DA. METHODS: A 67-year-old man with a 7-year diagnosis of PD treated with levodopa and pramipexole presented with a dramatic change in sexual behavior after an increase in DA dose. RESULTS: The patient, who historically was a very shy and conservative person, started to present increased frequency of sexual intercourse with his wife, during which he began speaking obscenities with an extreme preference for anal intercourse, preferences never requested before. After pramipexole was withdrawn, complete remission was observed with return to his usual sexual behavior. CONCLUSIONS: Hypersexuality and paraphilias are complications not uncommonly found in patients with PD under dopaminergic treatment. Further studies are needed for the understanding of this complex complication, and particularly the most prevalent relationship between pathological hypersexuality and use of DAs.

PMID: 18466265 [PubMed - indexed for MEDLINE]

[heavyiron]

Gambling and increased sexual desire with dopaminergic medications in restless legs syndrome.

Driver-Dunckley ED (http://forums.rxmuscle.com/pubmed?term=%22Driver-Dunckley%20ED%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsP anel.Pubmed_RVAbstract), Noble BN (http://forums.rxmuscle.com/pubmed?term=%22Noble%20BN%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsP anel.Pubmed_RVAbstract), Hentz JG (http://forums.rxmuscle.com/pubmed?term=%22Hentz%20JG%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsP anel.Pubmed_RVAbstract), Evidente VG (http://forums.rxmuscle.com/pubmed?term=%22Evidente%20VG%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsP anel.Pubmed_RVAbstract), Caviness JN (http://forums.rxmuscle.com/pubmed?term=%22Caviness%20JN%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsP anel.Pubmed_RVAbstract), Parish J (http://forums.rxmuscle.com/pubmed?term=%22Parish%20J%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsP anel.Pubmed_RVAbstract), Krahn L (http://forums.rxmuscle.com/pubmed?term=%22Krahn%20L%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsP anel.Pubmed_RVAbstract), Adler CH (http://forums.rxmuscle.com/pubmed?term=%22Adler%20CH%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsP anel.Pubmed_RVAbstract).
Department of Neurology, Parkinson's Disease and Movement Disorders Center, Mayo Clinic, 13400 E. Shea Boulevard, Scottsdale, AZ 85259, USA. [email protected]
OBJECTIVES: Do patients with restless legs syndrome (RLS) report gambling or other abnormal behaviors as previously reported in Parkinson disease. METHODS: This survey study was sent to 261 idiopathic RLS patients, and it included the Gambling Symptoms Assessment Scale, Altman Self-Rating Mania Scale, and questions pertaining to sexual activity and novelty-seeking behaviors. RESULTS: Ninety-nine patients responded to the survey, and 77 were actively taking 1 or more dopaminergic medications. Of the 70 respondents who answered the gambling questions, 5 (7%) noted a change in gambling, with 4 (6%; 95% confidence interval, 2%-14%) stating that increased urges and time spent gambling occurred specifically after the use of dopaminergic medications (2 on pramipexole, 1 on ropinirole, and 1 on levodopa and pramipexole). Increased sexual desire was reported by 4 (5%) of the 77 respondents, 3 (4%; 95% confidence interval, 1%-11%) reported that this occurred specifically after the use of dopaminergic medications (1 on pramipexole, 1 on ropinirole, and 1 on levodopa). One patient reported both an increase in gambling and sexual habits. CONCLUSIONS: This exploratory survey study revealed the development of gambling and/or increased sexuality in patients with RLS. These data raise the possibility that, as in Parkinson disease, RLS patients should be cautioned about potential behaviors that may occur with the use of dopaminergic medications. Further prospective studies are needed to assess the relationship between these medications and compulsive behaviors associated with the treatment of RLS.

PMID: 17909302 [PubMed - indexed for MEDLINE]

[heavyiron]

He says no.

I looked at the side effects on the mayo clinic website and the most common are insomnia, headaches, runny nose, constipation, dry mouth, & weight loss.

Effect of pramipexole on RLS symptoms and sleep: a randomized, double-blind, placebo-controlled trial.

Ferini-Strambi L (http://forums.rxmuscle.com/pubmed?term=%22Ferini-Strambi%20L%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsP anel.Pubmed_RVAbstract), Aarskog D (http://forums.rxmuscle.com/pubmed?term=%22Aarskog%20D%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsP anel.Pubmed_RVAbstract), Partinen M (http://forums.rxmuscle.com/pubmed?term=%22Partinen%20M%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsP anel.Pubmed_RVAbstract), Chaudhuri KR (http://forums.rxmuscle.com/pubmed?term=%22Chaudhuri%20KR%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsP anel.Pubmed_RVAbstract), Sohr M (http://forums.rxmuscle.com/pubmed?term=%22Sohr%20M%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsP anel.Pubmed_RVAbstract), Verri D (http://forums.rxmuscle.com/pubmed?term=%22Verri%20D%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsP anel.Pubmed_RVAbstract), Albrecht S (http://forums.rxmuscle.com/pubmed?term=%22Albrecht%20S%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsP anel.Pubmed_RVAbstract).
Institute San Raffaele Turro, Milan, Italy.
BACKGROUND: Patients with Restless Legs Syndrome (RLS) often seek treatment because of sleep problems related to nocturnal symptoms. Our goal was to test the ability of pramipexole to improve sleep in RLS patients and to reconfirm its efficacy for primary RLS symptoms. METHODS: Adults with moderate or severe RLS were randomized to receive placebo or pramipexole (flexibly titrated from 0.25 to 0.75mg), 2-3h before bedtime for 12 weeks. The co-primary outcome measures were change in Medical Outcomes Study (MOS) sleep disturbance score and International RLS Study Group Rating Scale (IRLS) score at 12 weeks. RESULTS: The intent-to-treat population included 357 patients: 178 received pramipexole and 179 received placebo. At 12 weeks, the adjusted mean change from baseline was greater for pramipexole (vs. placebo) for IRLS score (-13.4+/-0.7 vs. -9.6+/-0.7) and MOS sleep disturbance score (-25.3+/-1.5 vs. -16.8+/-1.5) (p<or=0.0001; ANCOVA). Responder rates (clinical and patient global impression and IRLS) were also significantly higher in the pramipexole group. RLS-QOL score was improved over placebo at Week 12 (p<0.01) as were MOS sleep adequacy (p=0.0008) and quantity (p=0.08) scores. Nine percent of patients in each group withdrew because of adverse events. CONCLUSIONS: Pramipexole is effective and well-tolerated for RLS and related sleep disturbance.

PMID: 18952497 [PubMed - indexed for MEDLINE]

[apex23]

I am currently using it and it makes me horny as hell. No side effects for me.

I have not noticed any fatloss, but then again I am bulking.

[heavyiron]

I am currently using it and it makes me horny as hell. No side effects for me.

I have not noticed any fatloss, but then again I am bulking.
Have you had any urges to gamble :p

[Kate1]

have you had any urges to gamble :p

lol!

[GeminiJedi]

Careful with it and it's antidepressant properties. Sometimes anti-depressants can make a person feel even more messed up than before taking the drugs--hence the warning on ALL anti-depressants warning against suicidal thoughts while on them.

I know a couple of people (non-body builders) who have been on it and had very negative side-effects from it. I also work in a pharmacy and do see a fair amount of prescriptions for it. Personally, I think RLS was made up by the drug companies to push more pills into the mouths of the hypochondriacs infesting the country....but that's just me http://www.freesmileys.org/smileys/smiley-angelic002.gif (http://www.freesmileys.org/smileys.php)

[Reloaded]

^^^ thanks for raining on my parade, Sally, did it make hubby horny?

[Jello]

There was a guy on promuscle message boards that almost died from it. Do your research.This shit is given to Parkinsons disease patients. Not nothing to be taken lightly. I dont have a good feeling about it and have researched it quite a bit. My advice? Stay away

You must have only read the title to that thread and not the whole thing. He started out with 1mg when it's recommended to start at .25 and work your way up. He also was not eating correctly and it looks like from his symptoms and food intake that he started to go Hypo.

[heavyiron]

You must have only read the title to that thread and not the whole thing. He started out with 1mg when it's recommended to start at .25 and work your way up. He also was not eating correctly and it looks like from his symptoms and food intake that he started to go Hypo.
I love the stuff but man you have to start slow on it. I started with .25mg and felt like I was shot with a tranqualizer. I am up to 1 mg now and that effect has lessened.

[sassy69]

You must have only read the title to that thread and not the whole thing. He started out with 1mg when it's recommended to start at .25 and work your way up. He also was not eating correctly and it looks like from his symptoms and food intake that he started to go Hypo.


Generally if people died that easily from the stuff you see discussed on muscle boards, you'd see a lot more dead bodies. Its usually not as simple as "he took this & died". So important to know what you're dealing with, but also paying attention to the basic stuff.

[Ninja Loco]

when I read regular reviews of the drug off Rx websites, people complain of weight gain...
Now seriously, Querida....dont all people not reading RX gain weight? :D



OOOOOOOOOOOOOOOOOOOOOOhhhhhhhhhhh the amount of ass sniffery here was almost too much even for me.


Seriously where did Jeff get it? Does he get body acne and did it help him with that if he does?

[sassy69]

Check our recently posted Chemical Profiles page on Prami for more info/studies:

Pramipexole - RX Muscle Forums