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View Full Version : Could Tetracycline antibiotics hinder muscle growth?



ultimate
08-23-2009, 11:08 AM
First off, i must say my knowledge of human physiology is incredibly poor otherwise i wouldn't be asking this question lol, sorry if it's stupid.

I have recently been put on Lymecycline a tetracycline antibiotic, to treat acne, (strangely i have had moderate acne on small area of my face for a few months and im 20 years old, doctor said it was normal though).

I was reading the mechanism of action on wikipedia and here it is;



Tetracycline antibiotics are protein synthesis inhibitors (http://en.wikipedia.org/wiki/Protein_synthesis_inhibitor), inhibiting the binding of aminoacyl-tRNA (http://en.wikipedia.org/wiki/Aminoacyl-tRNA) to the mRNA-ribosome (http://en.wikipedia.org/wiki/MRNA-ribosome) complex. They do so mainly by binding to the 30S ribosomal subunit (http://en.wikipedia.org/wiki/30S_ribosomal_subunit) in the mRNA translation (http://en.wikipedia.org/wiki/MRNA_translation) complex.
Tetracyclines also have been found to inhibit matrix metalloproteinases (http://en.wikipedia.org/wiki/Matrix_metalloproteinases). This mechanism does not add to their antibiotic effects, but has led to extensive research on chemically modified tetracyclines or CMTs (like incyclinide (http://en.wikipedia.org/w/index.php?title=Incyclinide&action=edit&redlink=1)) for the treatmet of rosacea (http://en.wikipedia.org/wiki/Rosacea), acne (http://en.wikipedia.org/wiki/Acne) and various types of neoplasms (http://en.wikipedia.org/wiki/Neoplasm)."

Im going to be taking it for 4 months, the protein synthesis inhibitor part grabbed my attention, is this going to have any effect on muscle growth?

napafit
08-28-2009, 04:34 AM
Im going to be taking it for 4 months, the protein synthesis inhibitor part grabbed my attention, is this going to have any effect on muscle growth?

I'm not a science wizz, however I remember some stuff from college. I believe the protein in which tetracycline and all the other "cycline" meds are related to metabolic functions of bacteria. Bacteria have cell walls that contain protein and so the "protein synthesis inhibitor part" refers to the inhibition of bacterial growth...

These tetracycline is specific for bacteria. If it wasn't it would inhibit overall protein synthesis in our body thus killing us by breaking down every tissue in our bodies...

So I wouldnt worry about it hindering ur gains in the gym.

B7emm
08-28-2009, 05:52 AM
i have taken tetracycline in the past and it didn't hinder any gains as far as i know.