Nootropics: A guide to Smart Drugs

[Sistersteel]

Piracetam (2-oxo-Pyrrolidine Acetamide) - is a derivative of the neurotransmitter GABA (Gamma Amino Butyric Acid). Chemically related to the amino acid Pyroglutamic Acid (Pyrrolidine Carboxylic acid), which occurs in cerebrospinal fluid and plays an important role in cognitive functioning.

-Biochemical Effects-
-Enhances Brain Metabolism (By increasing Glucose Utilization, Blood & Oxygen Flow)**Boosts mental energy & cerebral circulation**
-Increases Cerebral Phospholipids & Cellular Membrane Fluidity (By interacting with the polar head moieties of the phospholipid bilayer) **Supports healthy neuron communication & structure**.
Supports Cognitive Receptors (By amplifying the density of the Muscarinic Cholinergic **Frontal Cortex, Striatum, & Hippocampus**, NMDA (N-Methyl-D-Aspartate) **Hippocampus**, & AMPA (Alpha-amino-3-hydroxy-5-Methyl-4-isoxazole-Propionic Acid) Cerebral Cortex Receptors **Strengthens neurotransmitter receptors involved in memory and neuroprotection**
-Stimulates the Corpus Callosum, an area of the brain that controls communication between the left and right hemispheres (Increases communication between both hemispheres) **Involved in speech and creative thinking**.
- Stimulates the Locus Coeruleus, (specialized neurons) **Involved in information processing, attention, cortical/behavioral arousal, learning and memory**
-Inhibits Platelet Aggregation (By increasing Red-White blood cells & Platelet deformability, inhibiting thromboxane A2 synthetase or antagonism of thromboxane A2, reducing von Willebrand's factor & fibrinogen levels) **Supports Healthy Blood Flow**.
-Decreases EEG complexity (Increases cooperatively of brain functional processing) **Positively effects Neuro-Electrical Functioning**.
-Has a significant antioxidant effect.

-Overview-
Piracetam positively supports healthy cognitive & cardiovascular functioning by a multifaceted means of action.

-Notes-
Approved & used since 1970’s worldwide (Europe, Asia, and South American) for various health conditions. Recommended by many healthcare professionals and health organizations, such as the Life Extension Foundation, as a Nootropic.
Piracetum is the first step in the use of nootropics, it also stacks nicely with all of the following.

-Dose-
2-6 grams daily.

Kicks in within an hour to a few days.

[Sistersteel]

Aniracetam - Aniracetam (1-Anisoyl-2-pyrrolidinone) is a fat soluble potent analog of Piracetam.

-Biochemical Effects-
Similar to Piracetam, but due to its fat solubility its effects last longer and is far more potent.
- Helps increase communication between your left and right sides of the brain, resulting in improved creatively, perception, and more.
- Has an more potent AMPA receptor enhancing effect than Piracetam, resulting in better focus and concentration.
- Been reported to be best ‘cetam for anti-anxiety effects

-Dose-
750-1,500 mg daily with meals.

Kicks in within an hour to a few days.

[Sistersteel]

Oxiracetam - (4-hydroxy-2-oxo-1-pyrrolidinacetamide) is a potent fast acting water soluble analog of Piracetam. Works faster than all other racetams.

-Biochemical Effects-
Similar to Piracetam, but much stronger than Aniracetam and far faster acting. The preferred premium Nootropic for the elite smart drug user.
- Supports multiple aspects of Cognition
- Boosts Brain ATP levels (Mental Energy)
- Increase Choline Acetylcholinetranferase the neuro-enzyme that creates Acetylcholine (in the cerebral cortex, hippocampus and striatum) **Memory Support**

-Dose-
800-1,600 mg daily.

Kicks inwithin an hour to a few days.

[Sistersteel]

Pramiracetam (N-{2-(diisopropylamino)ethyl}-2-oxo-1-pyrrolidine-acetamide) is a fat soluble potent analog of Piracetam, the most potent Racetam compound being about 15 times stronger than Piracetam.

-Dose-
100-300mg daily

Availability
Sporadic due to customs issues.

[Sistersteel]

L-Huperzine - A is a natural plant alkaloid (extracted from Huperzia serrata), which quickly and potently boosts memory, learning, and concentration. Used worldwide for decades in adults and high school students. Is considered the most potent short term memory enhancer available.

-Biochemical Effects-
- Potently raises Acetylcholine (main memory neurotransmitter) by inhibiting its breakdown from Acetylcholinesterase.
- Strengthens the Brain's NMDA receptors (Enhances Focus, Learning, and Brain Functioning)

-Dose-
Take 200-400 mcg daily for best results with meals.

Kicks in within an hour to a few days.

[Sistersteel]

Alpha GPC (Alpha L-GlycerylPhosphorylCholine), also known as choline alfoscerate, is an unique NeuroActive form of choline that rapidly penetrates the blood brain barrier, naturally found in small amounts in milk and soybeans.

-Biochemical Effects-
- A precursor for the neurotransmitter AcetylCholine [Supports Memory].
- A precursor for PhosphatidylCholine [Supports Brain Structure]

-Dose-
300-2000 mg daily.

Kicks in within a few days.

[Sistersteel]

Vinpocetine (Ethyl Apovincamine) is a derivative of vincamine (a phytonootropic from periwinkle). While less potent as a mental stimulant than vincamine, Vinpocetine is the preferred nootropic for Enhancing blood flow to the Brain, Eyes, and Ears. Its effects on Cerebral Blood Flow far exceeds all other nootropics.

-Biochemical Effects-
-Enhances Brain Metabolism (By increasing Glucose Utilization, Blood & Oxygen Flow) (Boosts mental energy & cerebral circulation)
- Stimulates the Locus Coeruleus, (specialized neurons) (Involved in information processing, attention, cortical/behavioral arousal, learning and memory)
-Inhibits Platelet Aggregation (Reduces abnormal blood clots).
-Has a significant antioxidant effect.

-Dose-
20-40 mg daily with meals.

[Sistersteel]

Theanine (gamma-ethylamino-L-glutamic acid) is an unique amino acid found in trace amounts in green tea. It converts in the brain into GABA, the neurochemical involved in inhibiting over active mental activities, such as stress, anxiety, worrying, and nervousness. Unlike herbs theanine protects & enhances Cognition, without causing sleepy or drowsiness.


-Biochemical Effects-
- Instant relaxation due to its potent effects on raising GABA
- Unlike the supplement GABA it passes through the blood brain barrier readily and has superior GABA raising effects.
- Has been studied compared to Paxil.

-Notes-
In Japan it is used in soft drinks much like caffeine is added in the US, but to relax rather than stimulate the mind.

-Dose-
200-1000mg daily.

Kicks in within a few hours.

[Sistersteel]

Acetyl-L-Carnitine (2-Acetoxy-3-(trimethylaminium)butanoic acid) is an amino acid-like compound related to Choline found in high levels in brain cells.

-Biochemical Effects-
- Increases Acetylation of Coenzyme A (a precursor to Acetylcholine) [Memory Enhancer]
- Enhances transport of fatty acids into the mitochondria

[I]-Dose-
500-3000mg daily

[Sistersteel]

Choline supplements should be taken during the administration of all nootropics. Lecithin (caps and granules) is a cheap choline source. Lecithin should be taken in doses of 5-8 grams daily to support the nootropics. Alpha GPC (listed above) is another source for choline. It is more effective / more expensive, but only requires dosing in the 1-3 gram range to support choline levels in the brain.

[Sistersteel]

Stack Suggestions

Beginner's Stack :
1-2 grams piracetam every 8 hours with 5 grams lecithin daily.

Beginner's Study Stack
1-2 grams piracetam every 8 hours / 5 grams lecithin / 10mg Vinpocetine every 8 hours

Advanced Stack :
2 grams piracetam every 8 hours
500 mg aniracetam every 8 hours
1 gram Alpha GPC every 8 hours

Study Stack - advanced :
1.5 grams piracetam every 8 hours
500 mg aniracetam every 8 hours
1.5 grams Alpha GPC every 8 hours
15 mg Vinpocetine every 8 hours
150 mcg Huperzine every 8 hours

Anxiety / Concentration Stack :
500 mg aniracetam every 8 hours
200 mg theanine every 8 hours (plan for one dose prior to a speech or presentation)

This-is-good-shit stack..lol
500mg Theanine
1.5 grams Phenibut (do not study on phenibut)
5 grams lecithin


Premixed Nootropics Stacks:

NeuroStim + C
http://www.tritonhealth.com/neurostim-c.php

Focus XT
http://www.discountanabolics.com/p/SN18

These are very useful for using as bases to homemade stacks and are pretty hard to beat for PreWO mixes. Add a little chocamine or AMP/HEAT for a more potent mix.

[Sistersteel]

Some info on Chocamine..

Chocamine is a proprietary cocoa extract meant to provide the stimulation and health benefits of chocolate without any of the unnecessary, potentially unhealthy ingredients (such as sugar and fat). It contains numerous constituents, including methylxanthines (theobromine, caffeine, and theophylline), biogenic amines (phenylethylamine, tyramine, and according to one source, synephrine), amino acids (phenylalanine, tryptophan, tyrosine, others), minerals (with a high content of magnesium), numerous beneficial antioxidants, and possibly some non-psychoactive cannabanoid-related compounds. The combination of these multiple ingredients produces a unique effect. Promotional literature makes many positive claims about Chocamine, including increased energy, appetite suppression, increased lipolysis (fat burning), improved mood, improved concentration, increased alertness, improved physical performance, aphrodisiac properties, and health benefits. This article will examine the properties of some of the known constituents of Chocamine.

The methylxanthines are a group of compounds that include caffeine and some related stimulants. Chocamine contains methylxanthines such as theobromine, caffeine, and theophylline. Each gram of Chocamine contains 120 mg theobromine and 80 mg caffeine.

Theobromine is similar in both structure and function to caffeine, but it has a longer half-life, which may be one of the reasons chocamine has the reputation of being a "long-lasting stimulant." Theobromine also has a relative potency a few orders of magnitude lower than caffeine, but the amount in Chocamine (assuming a gram or more is taken) is still enough to have a psychoactive effect.

[Sistersteel]

DMAE

1. What are they and where do they come from?

DMAE - Dimethylaminoethanol - is an antioxidant and a precursor of the neurotransmitter Acetycholine (ACh). Acetycholine is responsible for feelings of well-being and relaxation.

It plays an important role in the onset of a dreaming state. DMAE is available in supplement form. It can be consumed orally, or used as a cream topically.

2. What does it do and what scientific studies give evidence to support this?

Although the science has not yet reached a conclusive, supportable, position on the exact function(s) of DMAE, anecdotal evidence suggests that DMAE supplementation is very beneficial. For example, anecdotal evidence indicates that DMAE may be appropriate for cosmetic purposes, due to its ability to reduce facial sag. DMAE may be helpful in improving memory and learning ability.

DMAE supplementation has been known to increase energy levels, as well as alleviate the symptoms typically following the consumption of large quantities of alcohol. Supplementing with DMAE can also offset the symptoms associated with long-term use of antipsychotic drugs. It may also have positive benefits for dreaming and mood stabilization.

3. Who needs it and what are some symptoms of deficiency?

There are no known symptoms of deficiency. Everyone can benefit from supplementing with DMAE. Populations that may benefit most from the supplementation of DMAE include: The Elderly, Athletes, persons on antipsychotic medication, children suffering from down syndrome and attention deficit disorder (ADD), and individuals who wish to use DMAE for its cosmetic applications.

Elderly persons are at an increased risk of developing depression. The onset of depression in elderly populations can be caused by a number of factors. DMAE can help alleviate or prevent symptoms of depression because of its ability to stabilize emotions and increase energy.

Increased energy levels are something that athletes require. High-intensity physical activity is very demanding. By supplementing with DMAE, athletes may notice shorter recovery times and improved athletic performance. DMAE also plays a role in muscle contractions (by being a precursor to ACh)

Person suffering from psychiatric conditions, children with attention deficit disorder and persons with down syndrome, may find that, due to its ability to stabilize moods and improve behavior, DMAE is a worthwhile substance to add to their treatment programs.

DMAE, as mentioned, also has a cosmetic application. While it is not a "facelift in a bottle", DMAE can serve to tighten the skin when applied topically. This may reduce signs of aging. Individuals with a PABA (Para-Amino-benzoic-acid) allergy should avoid supplementing with DMAE because DMAE is a chemical relative of PABA.

4. How much should be taken? Are there any side effects?

DMAE is non-toxic and is safe for human use. However, it is recommended that label directions always be followed. Overdosing with DMEA can result in insomnia, headaches and muscle tension. Persons suffering from Alzheimer's disease, depression, or other psychiatric conditions should consult a physician prior to supplementing with DMAE.

5. Where can I get it?

There are different brand names that manufacture supplemental DMAE

[tight booty]

Some info on Chocamine..

Chocamine is a proprietary cocoa extract meant to provide the stimulation and health benefits of chocolate without any of the unnecessary, potentially unhealthy ingredients (such as sugar and fat). It contains numerous constituents, including methylxanthines (theobromine, caffeine, and theophylline), biogenic amines (phenylethylamine, tyramine, and according to one source, synephrine), amino acids (phenylalanine, tryptophan, tyrosine, others), minerals (with a high content of magnesium), numerous beneficial antioxidants, and possibly some non-psychoactive cannabanoid-related compounds. The combination of these multiple ingredients produces a unique effect. Promotional literature makes many positive claims about Chocamine, including increased energy, appetite suppression, increased lipolysis (fat burning), improved mood, improved concentration, increased alertness, improved physical performance, aphrodisiac properties, and health benefits. This article will examine the properties of some of the known constituents of Chocamine.

The methylxanthines are a group of compounds that include caffeine and some related stimulants. Chocamine contains methylxanthines such as theobromine, caffeine, and theophylline. Each gram of Chocamine contains 120 mg theobromine and 80 mg caffeine.

Theobromine is similar in both structure and function to caffeine, but it has a longer half-life, which may be one of the reasons chocamine has the reputation of being a "long-lasting stimulant." Theobromine also has a relative potency a few orders of magnitude lower than caffeine, but the amount in Chocamine (assuming a gram or more is taken) is still enough to have a psychoactive effect.
Sounds fantastic!

[tribal]

subultamine

[LookImDancinCrazy!]

Vinpocetine (Ethyl Apovincamine) is a derivative of vincamine (a phytonootropic from periwinkle). While less potent as a mental stimulant than vincamine, Vinpocetine is the preferred nootropic for Enhancing blood flow to the Brain, Eyes, and Ears. Its effects on Cerebral Blood Flow far exceeds all other nootropics.

-Biochemical Effects-
-Enhances Brain Metabolism (By increasing Glucose Utilization, Blood & Oxygen Flow) (Boosts mental energy & cerebral circulation)
- Stimulates the Locus Coeruleus, (specialized neurons) (Involved in information processing, attention, cortical/behavioral arousal, learning and memory)
-Inhibits Platelet Aggregation (Reduces abnormal blood clots).
-Has a significant antioxidant effect.

-Dose-
20-40 mg daily with meals.

Can also negatively impact total leukocyte count (white blood cells). Would not be a good choice for anyone with impaired immunity or chronic infections of any sort.

Not appropriate for anyone with low blood pressure as it will temporarily lower BP.

Definitely works though.

[LookImDancinCrazy!]

I'm amazed the mackdaddy of vasodilators isn't in this list, plain old nicotinic acid (Niacin)

Take care to purchase this form and not the semi-synthetic "no flush" form which can be hepatotoxic in higher, frequent doses.

You'd better titrate your dose in order to avoid a massive flush. No more than 200-300mg taken after a full meal to start. I've gone as high as 3000mg total daily in divided doses with no flushing at all once acclimated. Nicotinic acid also lowers triglycerides so it might be good adjunctive therapy if you're running AAS that tends to raise those levels.

[ZenFit]

if you ladies want to try someting totally euphoric, then please try U4EA-X.. Jon Gray who wrote "Men Are From Mars and Women Are From Venus" endorces it as well.. i guarentee you will totally be hooked!!!

[ZenFit]

Piracetam (2-oxo-Pyrrolidine Acetamide) - is a derivative of the neurotransmitter GABA (Gamma Amino Butyric Acid). Chemically related to the amino acid Pyroglutamic Acid (Pyrrolidine Carboxylic acid), which occurs in cerebrospinal fluid and plays an important role in cognitive functioning.

-Biochemical Effects-
-Enhances Brain Metabolism (By increasing Glucose Utilization, Blood & Oxygen Flow)**Boosts mental energy & cerebral circulation**
-Increases Cerebral Phospholipids & Cellular Membrane Fluidity (By interacting with the polar head moieties of the phospholipid bilayer) **Supports healthy neuron communication & structure**.
Supports Cognitive Receptors (By amplifying the density of the Muscarinic Cholinergic **Frontal Cortex, Striatum, & Hippocampus**, NMDA (N-Methyl-D-Aspartate) **Hippocampus**, & AMPA (Alpha-amino-3-hydroxy-5-Methyl-4-isoxazole-Propionic Acid) Cerebral Cortex Receptors **Strengthens neurotransmitter receptors involved in memory and neuroprotection**
-Stimulates the Corpus Callosum, an area of the brain that controls communication between the left and right hemispheres (Increases communication between both hemispheres) **Involved in speech and creative thinking**.
- Stimulates the Locus Coeruleus, (specialized neurons) **Involved in information processing, attention, cortical/behavioral arousal, learning and memory**
-Inhibits Platelet Aggregation (By increasing Red-White blood cells & Platelet deformability, inhibiting thromboxane A2 synthetase or antagonism of thromboxane A2, reducing von Willebrand's factor & fibrinogen levels) **Supports Healthy Blood Flow**.
-Decreases EEG complexity (Increases cooperatively of brain functional processing) **Positively effects Neuro-Electrical Functioning**.
-Has a significant antioxidant effect.

-Overview-
Piracetam positively supports healthy cognitive & cardiovascular functioning by a multifaceted means of action.

-Notes-
Approved & used since 1970’s worldwide (Europe, Asia, and South American) for various health conditions. Recommended by many healthcare professionals and health organizations, such as the Life Extension Foundation, as a Nootropic.
Piracetum is the first step in the use of nootropics, it also stacks nicely with all of the following.

-Dose-
2-6 grams daily.

Kicks in within an hour to a few days.
you guys should definately try U4EA-X! its all natural and helps with anxiety, stress (works as a mood stabalizer) also helps with sleep and all in all just puts you in a great "euphoric" mood!! hope you get a chance to try it! GOOD LUCK AND GOD BLESS!