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heavyiron
01-04-2010, 05:22 PM
Human Growth Hormone


Quick overview:

Active Life: Varies by injection method
Drug Class: Growth Hormone/IGF-1 Precursor (for injection)
Average Dose: Men 2-6 i.u. total daily
Acne: No
Water Retention: Rare
High Blood Pressure: Rare
Liver Toxic: No
Aromatization: No
Comments: High Anabolic/No Androgenic effects

In the human body growth hormone is produced by the pituitary gland. It exists at especially high levels during adolescence when it promotes the growth of tissues, protein deposition and the breakdown of subcutaneous fat stores. Upon maturation endogenous levels of GH decrease, but remain present in the body at a substantially lower level. In the body the actual structure of growth hormone is a sequence of 191 amino acids. Once scientists isolated this hormone, many became convinced it would exhibit exceptional therapeutic properties. It would be especially effective in cases of pituitary deficient dwarfism, the drug perhaps restoring much linear growth if administered during adolescence.

The 1980's brought about the first prepared drugs containing Human Growth Hormone. The content was taken from a biological origin, the hormone being extracted from the pituitary glands of human corpses then prepared as a medical injection. This production method was short lived however, since it was linked to the spread of a rare and fatal brain disease. Today virtually all forms of HGH are synthetically manufactured. The recombinant DNA process is very intricate; using transformed e-coli bacterial or mouse cell lines to genetically produce the hormone structure. It is highly unlikely you will ever cross the old biologically active item on the black market (such as Grorm), as all such products should now be discontinued. Here in the United States two distinctly structured compounds are being manufactured for the pharmaceutical market. The item Humatrope by Eli Lilly Labs has the correct 191 amino acid sequence while Genentech's Protropin has 192. This extra amino acid slightly increases the chance for developing an antibody reaction to the growth hormone. The 191 amino acid configuration is therefore considered more reliable, although the difference is not great. Protropin is still Anabolics 2002 considered an effective product and is prescribed regularly. Outside of the U.S., the vast majority of HGH in circulation will be the correct 191 amino acid sequence so this distinction is not a great a concern.

The use of growth hormone has been increasing in popularity among athletes, due of course to the numerous benefits associated with use. To begin with, GH stimulates growth in most body tissues, primarily due to increases in cell number rather than size. This includes skeletal muscle tissue, and with the exception of eyes and brain all other body organs. The transport of amino acids is also increased, as is the rate of protein synthesis. All of these effect are actually mediated by IGF-1 (insulin-like growth factor), a highly anabolic hormone produced in the liver and other tissues in response to growth hormone (peak levels of IGF-1 are noted approximately 20 hours after HGH administration). Growth hormone itself also stimulated triglyceride hydrolysis in adipose tissue, usually producing notable fat loss during treatment. GH also increases glucose output in the liver, and induces insulin resistance by blocking the activity of this hormone in target cells. A shift is seen where fats become a more primary source of fuel, further enhancing body fat loss.

Its growth promoting effect also seems to strengthen connective tissues, cartilage and tendons. This effect should reduce the susceptibility to injury (due to heavy weight training), and increase lifting ability (strength). HGH is also a safe drug for the "piss-test". Although its use is banned by athletic committees, there is no reliable detection method. This makes clear its attraction to (among others) professional bodybuilders, strength athletes and Olympic competitors, who are able to use this drug straight through a competition. There is talk however that a reliable test for the exogenous administration of growth hormone has been developed, and is close to being implemented. Until this happens, growth hormone will remain a highly sought after drug for the tested athlete.

But the degree in which HGH actually works for an athlete has been the topic of a long running debate. Some claim it to be the holy grail of anabolics, capable of amazing things. Able to provide incredible muscle growth and unbelievable fat loss in a very short period of time. Since it is used primarily by serious competitors who can afford such an expensive drug, a great body of myth further surrounds HGH discussion (among those personally unfamiliar). Many will state with the utmost confidence that the incredible mass of the Olympian competitors each year is 100% due to the use of HGH. Others have crossed bodybuilding materials claiming it to be a complete waste of money, an ineffective anabolic and barely worthwhile for fat loss. With its high price tag, certainly an incredibly poor buy in the face of steroids. So we have a very wide variety of opinions regarding this drug, whom should we believe?

It is first important to understand why there the results obtained from this drug seem to vary so much. A logical factor in this regard would seem to be the price of this drug. Due to the elaborate manufacturing techniques used to produce it, it is extremely costly. Even a moderately dosed cycle could cost an athlete between $75-$150 per daily dosage. Most are unable or unwilling to spend so much, and instead tinker around with low dosages of the drug. Most who have used this item extensively claim it will only be effective at higher doses. Poor results would then be expected if low amounts were used, or the drug not administered daily. If you cannot commit to the full expense of an HGH cycle, you should really not be trying to use the drug.
The average male athlete will usually need a dosage in the range of 4 to 6 I.U. per day to elicit the best results. On the low end perhaps 1 to 2 I.U. can be used daily, but this is still a considerable expense. Daily dosing is important, as HGH has a very short life span in the body. Peak blood concentrations are noted quickly (2 to 6 hours) after injection, and the hormone is cleared from the body with a half-life of only 20-30 minutes. Clearly it does not stick around very long, making stable blood levels difficult to maintain. The effects of this drug are also most pronounced when it is used for longer periods of time, often many months long. Some do use it for shorter periods, but generally only when looking for fat loss. For this purpose a cycle of at least four weeks would be used. This compound can be administered in both an intramuscular and subcutaneous injection. "Sub-Q" injections are particularly noted for producing a localized loss of fat, requiring the user to change injection points regularly to even out the effect. A general loss of fat seems to be the one characteristic most people agree on. It appears that the fat burning properties of this drug are more quickly apparent, and less dependent on high doses.

Other drugs also need to be used in conjunction with HGH in order to elicit the best results. Your body seems to require an increased amount of thyroid hormones, insulin and androgens while HGH levels are elevated (HGH therapy in fact is shown to lower thyroid and insulin levels). To begin with, the addition of thyroid hormones will greatly increase the thermogenic effectiveness of a cycle. Taking either Cytomel® or Synthroid® (prescription versions of T-3 and T-4) would seem to make the most sense (the more powerful Cytomel® is usually preferred). Insulin as well is very welcome during a cycle, used most commonly in an anabolic routine as described in this book under the insulin heading. Aside from replacing lowered insulin levels, use of this hormone is important as it can increase receptor sensitivity to IGF-1, and reduce levels of IGF binding protein-1 allowing for more free circulating IGF-1 (growth hormone itself also lowers IGF binding protein levelss'). Steroids as well prove very necessary for the full anabolic effect of GH to become evident. Particularly something with a notable androgenic component such as testosterone or trenbolone (if worried about estrogen) should be used. The added androgen is quite useful, as it promotes anabolism by enhancing muscle cell size (remember GH primarily effects cell number). Steroid use may also increase free IGF-1 via a lowering of IGF binding proteins. The combination of all of these (HGH, anabolics, insulin and T-3) proves to be the most synergistic combination, providing clearly amplified results. it is of course important to note that thyroid and insulin are particularly powerful drugs that involve a number of additional risks.

Release and action of GH and IGF-1: GHRH (growth hormone releasing hormone) and SST (somatostatin) are released by the hypothalamus to stimulate or inhibit the output of GH by the pituitary. GH has direct effects on many tissues, as well as indirect effects via the production of IGF-1. IGF-1 also causes negative feedback inhibition at the pituitary and hypothalamus. Heightened release of somatostatin affects not only the release of GH, but insulin and thyroid hormones as well.
HGH itself does carry with it some of its own risks. The most predominantly discussed side effect would be acromegaly, or a noticeable thickening of the bones (notably the feet, forehead, hands, jaw and elbows). The drug can also enlarge vital organs such as the heart and kidney, and has been linked to hypoglycemia and diabetes (presumably due to its ability to induce insulin resistance). Theoretically, overuse of this hormone can bring about a number of conditions, some life threatening. Such problems however are extremely rare. Among the many athletes using growth hormone, we have very few documented cases of a serious problem developing. When used periodically at a moderate dosage, the athlete should have little cause for worry. Of course if there are any noticeable changes in bone structure, skin texture or normal health and well being during use, HGH therapy should be completely halted.
In summary, the biggest mistake we can make with this drug is to get confused by the price tag. Even a relatively short cycle of this drug (and ancillaries) will cost in the thousand(s), not hundreds of dollars. We cannot jump to the conclusion that GH is therefore the most unbelievable anabolic. This hormone is simply very complex, and costly to manufacture (though it should be getting cheaper). If you were looking to achieve just a great mass gain the $1,000 would be better spent on steroids. Growth Hormone will not turn you into an overnight "freaky" monster and it is certainly not "the answer". Yes, it is a very effective performance enhancement tool. But it is more a tool for the competitive athlete looking for more than steroids alone can provide. There is little doubt that GH contributes considerably to the physiques and performance of many top bodybuilders and athletes. In this arena, the money spent on it is well justified, the drug obviously necessary. But outside of competitive sports it is usually not.

heavyiron
01-07-2010, 04:30 PM
Growth Hormone: All You Ever Wanted to Know About It! Written by Leigh Penman Wednesday, 25 November 2009 04:58

http://www.rxmuscle.com/images/stories/articles/Steroids/gh.jpg

Welcome to the first in a series where we take a closer look at steroids and peptides via an exclusive series of interviews with one of the head scientists at a major production laboratory.

First in line is Human Growth Hormone.....

So, first of all, why is Growth Hormone such an attractive drug to bodybuilders?

"HGH (and the IGF-1 that is a result of its use) is the only substance that can actually initiate hyperplasia. While the use of anabolic steroids can cause hypertrophy (the enlargement of existing muscle cells), steroids do not offer the ability to recruit and mature more muscle cells. HGH can. HGH also increases protein synthesis, which can be responsible for hypertrophy.

"You also have to understand that normally, after puberty, the body stops growing new muscle cells. The number of muscle cells is genetically fixed for the rest of the life span, and the most that can happen is to increase the size of these cells through weight training or steroids. However, by using HGH the body can actually grow new muscle cells. This allows the body to reverse genetic dispositions and achieve a desired muscle density."

For someone new to its use, what is a safe and effective starter dose?

"For gaining lean muscle and substantially improving body composition a dose of 4-8 i.u.'s a day will be necessary. Most people will respond very well at a dose of 4-5 i.u.'s per day. For maximum benefit in this regard, the addition of Testosterone, Insulin, and low dose T3 would be something to seriously consider.

"As a general rule the best way to start an HGH program is to start with a low dose and ease the administration into the higher doses. This will avoid, or at least minimize, many of the common side effects of HGH such as bloating, joint pain and swelling. Most people can tolerate approximately 2 i.u.'s with few side effects, so that would be the recommended starting dose. A scheduled program would look like this:

Week 1-4: HGH 2i.u.'s one injection
Week 5: HGH 2.5 i.u.'s one injection
Week 6: HGH 3 i.u.'s split into two injections of 1.5 i.u.'s each
Week 7: HGH 3.5 i.u.'s split into two injections of 1.75 i.u's each

If at any point in this progression unbearable bloating or joint pain becomes an issue, the dose must be reduced by 25% and held at a lower dosage for a couple of weeks. If the side effects subside, progression may resume back up towards desired level. If the side effects remain, the dose must be reduced again and held at a lower level for two weeks before beginning upward progression. This method will keep the HGH experience a good one with minimal side effects."

HGH is not administered like standard injectables, what is the injection procedure?

"HGH is dispensed in the form of a lyophilized powder. Any other form advertised is NOT true HGH. The only way to administer true HGH is by a sub-q or intramuscular injection.
"HGH is somewhat fragile by nature, and it needs to be protected from light and heat. HGH should be stored between 36 and 46 degrees Fahrenheit at all times both before and after its reconstitution. All brands of HGH should be refrigerated after being reconstituted, and all brands should be protected from light at all times."

Is there a best time of day for administration?

"The body produces HGH in a continuous pulsatile fashion throughout the day with the highest pulses occurring approximately 2-3 hours after going to bed and falling into deep sleep. Injectable HGH is completely absorbed and activates within approximately 3 hours. The strategy with respect to timing depends somewhat on age and other elements of the cycle. There is no single best strategy...it depends a lot on your individual situation."

Can you give us some examples?

"For those in their late 20's to early 50's, there is a chance that the endogenous production of HGH is still at a reasonable level. The best time to take an injection in this case would be early morning...after your body's own release of HGH in the night. If you get up to go to the bathroom in the early morning, this is probably the perfect time to take a couple of units of HGH. The second best time would be first thing in the morning when you wake up.

"If you are splitting your doses, it is good to take them when your cortisol levels are at a peak, which is when you wake up and in the early afternoon. Cortisol is very catabolic by nature and a well-timed HGH injection can go a long way to blunting this effect.

"Yet another strategy should be considered if one is using insulin with HGH. Insulin should be used immediately post work out. HGH and insulin do some great things together - they shuttle nutrients in a very complimentary way to each other - and the combination of HGH and insulin create the best environment for IGF-1 production. If one is using insulin immediately post workout, this would be a recommended time to take a number of units of HGH."

It has been claimed that lean body mass gains and fat loss are achieved with GH without and change being made to the diet, care to comment on this?

"A high protein diet is often recommended to help efforts to build muscle and lose fat. Adequate protein is required for building muscle and other tissues. Various sources advise people to consume anywhere from 0.6 to 1.5g of protein per pound of bodyweight per day."

How long does it take for results to kick in?

"It should be noted that for the vast majority of HGH users, results are not rapid and visible in nature. If your idea of using HGH is to get ripped in a few weeks , gaining 20lbs of muscle in a matter of a month or two, or being miraculously healed in a matter of a few injections...you are likely to be in for a BIG disappointment. HGH does some pretty incredible things, but it HAS to be viewed as a long term endeavor. A reasonable length HGH cycle would be 20-30 weeks in length. While you will always be able to find one or two individuals who will make great strides in a short amount of time, the majority need to be dedicated to its use for the long haul for it to be a worthy venture."

What effect does it have on the healing of damaged tissue that cannot be achieved by regular anabolics and why is this effect so profound?

"HGH has the ability to increase lean body mass, shorten a bodybuilder's recovery time between workouts, and improve overall athletic performance. HGH helps strengthen ligaments and joints, and promotes faster healing of damaged tissue. In addition, HGH can increase the body's capability for protein synthesis and for proper absorption of essential immune defensive molecules into the damaged site."

Some people use HGH to combat adrenal fatigue, could it also alleviate the symptoms of chronic fatigue syndrome?

"Adrenal fatigue is a term applied to a collection of non specific symptoms such as body aches, fatigue, nervousness, sleep disturbances and digestive problems. The term often shows up in popular health books and on alternative medicine web sites, but it isn't accepted medical diagnosis.
"The adrenal glands produce a variety of hormones that are essential to life. The medical term ‘adrenal insufficiency', or Addison's disease, refers to inadequate production of one or more of these hormones as a result of an underlying disease. Signs and symptoms of adrenal insufficiency include fatigue, body aches, unexplained weight loss, low blood pressure, light headedness and loss of body hair. Proponents of the adrenal fatigue diagnosis claim this is a mild form of adrenal insufficiency caused by chronic stress. The unproven theory behind adrenal fatigue is that your adrenal glands are unable to keep pace with the demands of perpetual fight-or-flight arousal. As a result, they can't produce quite enough of the hormones you need to feel good. Existing blood tests, according to this theory, aren't sensitive enough to detect such a small decline in adrenal function - but the body can. The latest research demonstrates that adrenal fatigue is connected to the growth hormone loop in a distinct way, since taking HGH releasers (consistently over many months) has helped to improve energy levels."

Finally, what is the best liquid to use when it comes to the reconstitution of HGH?

"Bacteriostatic Water (BW), Sterile Water or even liquid vitamin B12 can be used for reconstitution. What we choose to reconstitute it with should depend on how rapidly we use the GH. Bacteriostatic Water is basically sterile water with 0.9% Benzyl Alcohol added, and this alcohol keeps anything from growing in the water, thus making it safe for injection for the longest period of time...up to three weeks. For the common use for bodybuilding (2-5 i.u.'s a day) and the more commonly used vial size (10 i.u.'s) it isn't really critical which of the afore mentioned diluents are used...the vial will be used up long before bacteria or anything begins to grow in our reconstituted HGH."

http://www.rxmuscle.com/articles/chemical-enhancement/995-growth-hormone-all-you-ever-wanted-to-know-about-it.html

SallyAnne
01-15-2010, 02:46 PM
Article on HGH for Rx Muscle, written by Leigh Penman:

http://www.rxmuscle.com/articles/chemical-enhancement/995-growth-hormone-all-you-ever-wanted-to-know-about-it.html

Another written by John Romano:

http://www.rxmuscle.com/articles/chemical-enhancement/379-growth-hormones-great-disappearing-act.html

heavyiron
01-19-2010, 03:18 PM
Evidence that every other day injections of HGH produced better total growth in the kids than every day.


Prevention of Growth Deceleration after Withdrawal of Growth Hormone Therapy in Idiopathic Short Stature

Meir Lampit and Ze’ev Hochberg

Department of Pediatrics, Meyer Children’s Hospital, Haifa 31096, Israel
Address all correspondence and requests for reprints to: Dr. Ze’ev Hochberg, Division of Pediatric Endocrinology, Meyer Children’s Hospital, P.O. Box 9602, Haifa 31096, Israel. E-mail: . [email protected] ([email protected])

Abstract

The treatment of children with idiopathic short stature by daily injections of human GH (hGH) is followed after its withdrawal by a growth deceleration with normal serum GH and IGF-I levels. The present study was designed to understand and prevent growth deceleration. We hypothesized that this phenomenon is due to tolerance at the target organ level, that tolerance develops in response to the unphysiological pharmacokinetics of daily-injected hGH, and that alternate day hGH therapy will prevent it. Thirty-eight prepubertal children with idiopathic short stature, aged 3.3–9.0 yr, were studied. Their heights were less than -2 SD score, growth rate was above the 10th percentile for age, bone age was less than 75% of chronological age, and the stimulated serum GH concentration was greater than 10 µg/liter. The children were matched for sex, height, and growth velocity SD score to receive daily or alternate day hGH at the same weekly dose of 6 mg/m2 for a period of 2 yr. The 1st and 2nd year mean growth velocities were 3.4 and 2.3 SD score for the daily therapy group and 3.0 and 2.0 SD score for the alternate day group, respectively (P = NS). Over the initial 6 months after withdrawal of therapy, and growth velocity decelerated to a nadir of -3.9 SD score in the daily therapy group, whereas it decelerated in the alternate day group to only -0.2 SD score (P < 0.01). Over the entire 2 yr off therapy the latter group maintained mean growth rates of -0.2 to -1.2 SD score, similar to their pretreatment velocities. The daily group recovered slowly to resume their mean pretreatment rate only on the fourth semiannual evaluation off therapy. The cumulative 4-yr growth velocity (2 yr on and 2 yr off therapy) of the alternate day group was greater than that of the daily therapy group (mean, 0.9 vs. 0.3 SD score; P < 0.002). At the end of the 4-yr therapy period, the adult height prediction of the alternate day group was greater than that of the daily group by a mean 6.5 cm (P = 0.06). It is concluded that growth deceleration after withdrawal of hGH therapy in idiopathic short stature is due to tolerance to GH and IGF-I in response to the unphysiological pharmacokinetics of daily-injected hGH and that alternate day therapy allows for an alternate day physiological GH profile, thus preventing tolerance during therapy and growth deceleration thereafter.

s2h
01-20-2010, 07:35 PM
why does anybody put anything in amps?what a pain in the ass!

BigGameJames
09-01-2010, 03:15 AM
HGH is by far the best stuff ever. You will loose body fat and have strength gains that are crazy. You will also notice your hair a little oily and your skin will be very soft. It is a remarkable product that is very expensive. If you can get a Dr. and if you got the $$ then jump on it for 3-4 months. You will see a hug difference in your bosy as well as your cardio levels''

BigJD69
09-01-2010, 12:07 PM
Good read!

HGHZechariah
03-14-2011, 06:16 AM
I am a troll

Schmidy
11-06-2011, 01:12 AM
Good read cheers!

nitrous
11-08-2011, 09:47 PM
The 1980's brought about the first prepared drugs containing Human Growth Hormone. The content was taken from a biological origin, the hormone being extracted from the pituitary glands of human corpses then prepared as a medical injection. This production method was short lived however, since it was linked to the spread of a rare and fatal brain disease.

Interesting haha

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Mr.Dedication
08-12-2012, 11:35 AM
why does anybody put anything in amps?what a pain in the ass!

I have to agree with you on this. I don't understand it either.

Todd Lincoln
03-24-2013, 10:57 PM
Is carbohydrate consumption essential with usage...could it be used on a keto diet? Does anyone have an opinion on effectiveness of EOD vs ED usage?

data4
06-10-2015, 11:34 AM
Is carbohydrate consumption essential with usage...could it be used on a keto diet? Does anyone have an opinion on effectiveness of EOD vs ED usage?

It will raise BG levels so taking it away from carbs isnt a bad idea. Taking on training days when insulin sensitivity is increased form training will help as well.