natron
01-09-2010, 10:07 AM
Havoc (methepitiostane)
Androgenic 91
Anabolic 1100
Standard Methyltestosterone (oral)
Chemical Name 2alpha,3alpha-epithio-17alpha-methylSalpha-androstan-17beta-ol
Estrogenic Activity none
Progestational Activity none
Description:
Methepitiostane is an oral anabolic steroid derived from dihydrotestosterone. This agent is a c17-alpha alkylated analog of epitiostane (see Thioderon), and like this drug also displays a favorable balance between anabolic and androgenic effect. In this case, however, the separation is considerably more pronounced, with the drug exhibiting an anabolic effect that is roughly 12 times more pronounced than its androgenic effect.That is according to the standard animal assays, which often vary somewhat to experiences in humans. This drug was never clinical tested in humans, so what is known of it is based on a small number of animal experiments, and structural and anecdotal observations. What can be stated with certainty if that methepitiostane is a primarily anabolic steroid with a pronounced level of activity, and is effective for the promotion of lean mass and strength gains. It likely also imparts some anti-estrogenic effect, further strengthening the association between this agent and dieting, cutting, and lean muscle mass phases of training as opposed to bulking.
History:
Methepitiostane was first described in 1966, during investigations into a series of A-ring modified androstane derivatives.571 That same year it was assayed for anabolic and androgenic potency via the standard rat assays, and demonstrated both pronounced anabolic properties and very weak relative androgenicity.572 The assay results were probably most similar to desoxymethyltestosterone (Madol), although methepitiostane is about half as androgenic. Although the results of the early testing were very favorable, this agent never progressed to the point of being a commercial steroid product or even tested on human subjects. Like a great many steroids, it was examined but not actualized as a prescription product. For forty years, the agent would be lost to the public, existing as an item of research interest only.
Methepitiostane would emerge from research obscurity at the end of 2006, when a new company called Recomp Performance Nutrition introduced it to the U.S. market under the trade name Havoc. It would be sold openly as a dietary supplement.This channel of sales does not reflect a weak potency or "non-steroid" classification, however, as methepitiostane is very much a potent drug. It is being sold as such due to the fact that the u.s. dietary supplement market is not tightly regulated, and the drug was never classified (specifically according to the law) as an anabolic steroid. While regulations do exist that would prevent the sale of an unapproved new drug as a food supplement, they do not carry the same weight as the anabolic steroid laws, and have historically not been aggressively enforced. Methepitiostane remains on sale as of December 2006, although the manufacturer has stated that they plan to discontinue the product very shortly.
How Supplied:
Methepitiostane was never approved as a prescription drug preparation. It is being sold in the U.S. supplement market under the trade name Havoc, and is supplied in the form of capsules containing 10 mg of steroid.
Structural Characteristics:
Methepitiostane is a modified form of dihydrotestosterone. It differs by 1) the addition of a 17alpha methyl group, which helps protect the steroid from metabolism during oral administration, and 2) the replacement of 3-keto with 2,3 alpha-epithio, which increases anabolic strength while reducing relative androgenicity.
Administration (Men):
Methepitiostane was never approved for use in humans., Prescribing guidelines are unavailable. An effective dosage for physique-or performance-enhancing purposes falls in the range of 10-20 mg daily.This is usually taken for no longer than 6-8 weeks, in an effort to avoid significant liver strain. At this level the drug should impart a measurable but moderate lean-mass-building effect, which, depending on dietary and metabolic factors, may be accompanied by measurable fat loss and an increase in! definition. Doses of 30 mg per day are also commonly used, however given the high relative potency of the steroid may present significant hepatotoxicity. When administered, higher doses are usually taken for durations lasting no longer than 4-6 weeks.
Administration (Women):
Methepitiostane was never approved for use in humans. Prescribing guidelines are unavailable. An effective dosage for physique-or performance-enhancing purposes would be around 5 mg per day. This would be taken for no longer than 4-6 weeks, in an effort to avoid significant liver strain or virilizing side effects. Given that complete separation of anabolic and androgenic effect has not been achieved with any steroid, this agent is still capable of producing virilizing activity given the right dose or individual sensitivity.
Reference:
Llewellyn’s W. (2009). Anabolics (9th ed), Havoc methepitiostane (pp. 267-269): Jupiter, FL: Molecular Nutrition
Androgenic 91
Anabolic 1100
Standard Methyltestosterone (oral)
Chemical Name 2alpha,3alpha-epithio-17alpha-methylSalpha-androstan-17beta-ol
Estrogenic Activity none
Progestational Activity none
Description:
Methepitiostane is an oral anabolic steroid derived from dihydrotestosterone. This agent is a c17-alpha alkylated analog of epitiostane (see Thioderon), and like this drug also displays a favorable balance between anabolic and androgenic effect. In this case, however, the separation is considerably more pronounced, with the drug exhibiting an anabolic effect that is roughly 12 times more pronounced than its androgenic effect.That is according to the standard animal assays, which often vary somewhat to experiences in humans. This drug was never clinical tested in humans, so what is known of it is based on a small number of animal experiments, and structural and anecdotal observations. What can be stated with certainty if that methepitiostane is a primarily anabolic steroid with a pronounced level of activity, and is effective for the promotion of lean mass and strength gains. It likely also imparts some anti-estrogenic effect, further strengthening the association between this agent and dieting, cutting, and lean muscle mass phases of training as opposed to bulking.
History:
Methepitiostane was first described in 1966, during investigations into a series of A-ring modified androstane derivatives.571 That same year it was assayed for anabolic and androgenic potency via the standard rat assays, and demonstrated both pronounced anabolic properties and very weak relative androgenicity.572 The assay results were probably most similar to desoxymethyltestosterone (Madol), although methepitiostane is about half as androgenic. Although the results of the early testing were very favorable, this agent never progressed to the point of being a commercial steroid product or even tested on human subjects. Like a great many steroids, it was examined but not actualized as a prescription product. For forty years, the agent would be lost to the public, existing as an item of research interest only.
Methepitiostane would emerge from research obscurity at the end of 2006, when a new company called Recomp Performance Nutrition introduced it to the U.S. market under the trade name Havoc. It would be sold openly as a dietary supplement.This channel of sales does not reflect a weak potency or "non-steroid" classification, however, as methepitiostane is very much a potent drug. It is being sold as such due to the fact that the u.s. dietary supplement market is not tightly regulated, and the drug was never classified (specifically according to the law) as an anabolic steroid. While regulations do exist that would prevent the sale of an unapproved new drug as a food supplement, they do not carry the same weight as the anabolic steroid laws, and have historically not been aggressively enforced. Methepitiostane remains on sale as of December 2006, although the manufacturer has stated that they plan to discontinue the product very shortly.
How Supplied:
Methepitiostane was never approved as a prescription drug preparation. It is being sold in the U.S. supplement market under the trade name Havoc, and is supplied in the form of capsules containing 10 mg of steroid.
Structural Characteristics:
Methepitiostane is a modified form of dihydrotestosterone. It differs by 1) the addition of a 17alpha methyl group, which helps protect the steroid from metabolism during oral administration, and 2) the replacement of 3-keto with 2,3 alpha-epithio, which increases anabolic strength while reducing relative androgenicity.
Administration (Men):
Methepitiostane was never approved for use in humans., Prescribing guidelines are unavailable. An effective dosage for physique-or performance-enhancing purposes falls in the range of 10-20 mg daily.This is usually taken for no longer than 6-8 weeks, in an effort to avoid significant liver strain. At this level the drug should impart a measurable but moderate lean-mass-building effect, which, depending on dietary and metabolic factors, may be accompanied by measurable fat loss and an increase in! definition. Doses of 30 mg per day are also commonly used, however given the high relative potency of the steroid may present significant hepatotoxicity. When administered, higher doses are usually taken for durations lasting no longer than 4-6 weeks.
Administration (Women):
Methepitiostane was never approved for use in humans. Prescribing guidelines are unavailable. An effective dosage for physique-or performance-enhancing purposes would be around 5 mg per day. This would be taken for no longer than 4-6 weeks, in an effort to avoid significant liver strain or virilizing side effects. Given that complete separation of anabolic and androgenic effect has not been achieved with any steroid, this agent is still capable of producing virilizing activity given the right dose or individual sensitivity.
Reference:
Llewellyn’s W. (2009). Anabolics (9th ed), Havoc methepitiostane (pp. 267-269): Jupiter, FL: Molecular Nutrition