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SBT
01-18-2010, 11:45 PM
So what is need2slin?
Need2slin is a powerful Nutrition and carbohydrate shuttling
compound. It Shut guns carbohydrates and other nutrients To your muscles leaving them no chance of being stored as fat. By way of
increasing insulin (http://drugsprofiles.com/growth-hormone-and-peptides/insulin.html) sensitivity and carbohydrates/Nutrition up take Need2slin Improves Nutrition pertinence. This means carbs,sugars,fats other nutrients get used or stored in the muscle as energy rather then stared as fat. Moreover need2slin improves the dispelling of carbohydrates that are not used as well.

Now as if all this wasn't enough Needtobuildmuscle knows Our customers want more!! When hundreds of cheap products claim to do the same We at needtobuildmuscle always go the extra mile in our products. Simple we just like being flat out better then the rest.

So what else will one get from need2slin?

Well it does a variety of things that im sure you will find extremely exciting, if your looking for..

Increased LBM!

Rock hard, long lasting PUMPS!

Lower bodyfat!

Increased glycogen uptake!

Increased metabolism!

Improved thyroid function!

Increased Androgen receptor sensitivity!

Improved blood lipids

Increased vascularity

If these traits are desirable to you, then you neednt look any further, N2SLIN has arrived.
N2SLIN is a potent nutrient repartioner, it has a novel ingredient profile, it doesnt use cheaper alternatives, eg(berbarine) So it can be cycled all year round without pancreatic damage.

WHATS IT FOR?[b]

It can be used to increase lbm on a lean bulk, to increase strength, lower bodyfat, support good health, and to further gains in the gym.
Used 30 mins before meals, N2SLIN will push carbs into the muscles, giving you a food pump, it does this through 2 channels.

[B]FIRST.. Gymnema sylvestre, we will just call it G.S, pushes food into the muscle, as it mimicks insulin (http://drugsprofiles.com/growth-hormone-and-peptides/insulin.html), insulin (http://drugsprofiles.com/growth-hormone-and-peptides/insulin.html) is the most anabolic compound around, but VERY DANGEROUS!! Gymnema on the other hand has been proven to lower blood sugar levels, supporting lower cholesterol. And as a powerful insulin (http://drugsprofiles.com/growth-hormone-and-peptides/insulin.html) mimicker, it force feeds muscles with carbs, as the carbs are forced into muscle cells, the cells absorb..no infact they pull or suck water into their vicinity, along with vital nutrients, Protein (http://www.needtobuildmuscle.net/forum/../store/Protein-Products-c28/) and fats..all the building blocks muscles need, but what happens next?

SECOND.. Banaba leaf, 20 percent corosolic acid, works in a similar way, but with one big difference, it increases androgen receptor sensitivity, wich in turn increases localised IGF-1 (http://www.hardcoregrowth.com/products_igf_combo.html) in muscle tissue, IGF-1 (http://www.hardcoregrowth.com/products_igf_combo.html) is one of the most anabolic growth factors, helping tissue recovery, and growth, but also stimulating satelite cells in the muscle to start firing, meaning more muscle fibers!!! Bigger muscles!!
Also the increased androgen sensitivity means this..
Ever wondered why people can be fat with skinny arms? Because they have lots of androgen receptors in their arms, but in the belly lots of estrogen receptors, and these like to hold fat.
Well Banaba stimulates the ones that like to build muscle, and promote fat loss, and combined with Acetyl L-carnatine, they stimulate these receptors, and help change the bodies appearance over time.

A L-C also helps transport fat, to be used as energy, and not stored as fatty deposits, and where are all the nutrients being transported, to the muscle!!! So your depriving fat cells from being able to hold onto fat, and your feeding muscle cells everything they need to increase in size= less fat, more muscle!!!

Ok so what then?
Well have you heard of cAMP? Well real insulin (http://drugsprofiles.com/growth-hormone-and-peptides/insulin.html), actualy breaks down the enzyme that caused cAMP wich is why you can get fat if you were silly enough to use it, without going to scientific, cAMP is how your body metabolises fats to produce energy to feed muscles, increasing Protein (http://www.needtobuildmuscle.net/forum/../store/Protein-Products-c28/) metabolism in the process, so you get a greater metabolic rate, improved glycogen uptake, and increased Protein (http://www.needtobuildmuscle.net/forum/../store/Protein-Products-c28/) and fat synthesis. So all the calories you eat build muscle... that is if your training hard enough to stimulate the muscles to grow, And this process is carried out by Synephrine, one of the most powerful OTC cAMP stimulators available, and Coleus forskholi, wich also supports a healthy thyroid, and lowers the stress hormone cortisol, so increasing the anabolic enviroment, ideal for IGF-1 (http://www.hardcoregrowth.com/products_igf_combo.html) and cAMP to really get working!!
But how long does it work for?
G.S, and Banaba are very fast acting,Na R-Alpha lipoic acid, stays active for up to 6 hours, so think of it as a very powerfull but slow working G.S and Banaba combined, So you get this Anabolic window opened for up to 6 hours, 6 HOURS OF GROWTH!!!
As well as that Na R-Alpha lipoic acid is a very potent anti-oxidant and anti carcinogenic, so with the increased calories, and therfore the increase of toxins, you get a long lasting protection of oxidative stress on the human body.

That leaves us with just l-norvaline, at 200mg, that makes it very strong, L-norvaline boosts NO action, so increasing nitrogen retention, to add to the glycogen retention caused already, it increases blood flow, has been used to help with erectile function, and gives rock hard pumps!!!



GOOD, BUT HOW DO I USE IT?

2 caps 30 mins before a meal containing 40g carbs or more, this will shuttle the nutrients into the muscle, if you are on a big bulk, looking for large body mass increases, then 3 caps before a meal containing 60-100grams carbs.

N2SLIN will prevent any fat storage, but from the increased glycogen retention, and in turn as glycogen holds water, you may appear fatter, however if used for more than 6 weeks the effects of bodyfat decreasing, and muscle increasing will become very evident.
It can also be used before fasted cardio, to increase glut action, or the muscles ability to hold onto glycogen, and to boost gh (http://www.whatyouneedtoknowabouthgh.com/) secretion, by lowering blood sugar levels, plus its cortisol blocking effects will prevent catabolism of your hard earned muscle.

WHAT GAINS CAN I EXPECT?

Well depending on your diet and how well you use this, you could easily add a few lbs of lbm a month, and at the same time decrease bodyfat.

CAN I USE IT ON A CUT

Yes, it works very well, as it stops you from storing fat, but instead forces the nutrients to build muscle, use 1 cap before meals containing 10-20g carbs, 2 caps if 20-50.

Use one cap 3 times a day to lower cholesterol, and blood sugar levels, and elevate your bodies natural metabolism.

I will be providing a full meal and diet plan to get the most out of this very soon!!!

HOW LONG WILL IT LAST?

2 months at the reccomended dose.

CAN I STACK IT?

Its ideal to use with HCGenerate, and gear (http://www.needtobuildmuscle.net/forum/../store/Protein-Products/GEAR-p36.html), but can be used with creatine as both will gorge the muscles with nutrients, its great on a steroid or p/h cycle as it stops androgen receptors from being downgraded, and it can be used alone with good results.

Need2slin
2 caps per serving 60 servings per container.
1.) 450mg gymnema sylvestre, a whopping 75 percent gymnemic acids!!
2.) 250mg Acetyl L-carnatine
3.) 200mg NaR-ALA
4.) 200mg L-norvaline
5.) 90mg Coleus forskholi, 20 percent forskolin.
6.) 30mg synephrine HCI
7.) 18mg Banaba leaf.

wildcat22
01-20-2010, 08:39 PM
Thanks for the in depth explanation SBT. I am very interested in this product! I especially like the fact it can be used while dieting!!

needtogetaas
01-20-2010, 10:33 PM
Great product. If anyone has any questions feel free to ask.

needtogetaas
01-21-2010, 10:54 PM
If you do a net search on the product a lot of people are asking about it. This product rocks.

brandonp005
01-24-2010, 05:14 PM
I'm excited about giving this product a try.

SwolenONE
02-02-2010, 04:26 PM
Ive never used any of your stuff, but its looking great. Keep up the good work.

needtogetaas
02-02-2010, 05:01 PM
Ive never used any of your stuff, but its looking great. Keep up the good work.
Thanks good friend. :yep: I will have to check out some of yours too. I just got some products from brutal and they look sick. I just took a shot of ass lighting lol... Sounds funny saying it.

SwolenONE
02-03-2010, 09:19 AM
Thanks good friend. :yep: I will have to check out some of yours too. I just got some products from brutal and they look sick. I just took a shot of ass lighting lol... Sounds funny saying it.

lol, that does sound funny:p

Ill be sure to swap some products sometime, the lines on RX are all looking good and together we shall all thrive and continue to grow.

from a formulation standpoint, Ive never seen synephrine in a slin potentiating product, give me a heads up on the rhyme and reason when you get a chance. very cool formula though!

needtogetaas
02-03-2010, 11:28 AM
lol, that does sound funny:p

Ill be sure to swap some products sometime, the lines on RX are all looking good and together we shall all thrive and continue to grow.

from a formulation standpoint, Ive never seen synephrine in a slin potentiating product, give me a heads up on the rhyme and reason when you get a chance. very cool formula though!



For decades now Bodybuilders,power lifters,and professional
Athletes have Known about the powerful muscle building, fat burner effects of insulin. Athletes Of all kinds have mastered the art of using insulin and Insulin mimicking compounds to maximize muscles gains,increase strength, and burn of unwanted body fat.


So the questions Are. What is Insulin? what is a good Insulin mimicking compound? How do they work? And what can you do to jump on the gravy train?


Insulin is a hormone produced in the pancreas which helps to regulate glucose levels in the body. Medically, it is typically used in the treatment of diabetes. Recently, insulin has become quite popular among bodybuilders due to the anabolic effect it can offer. With well-times injections, insulin will help to bring glycogen and other nutrients to the muscle

Insulin has profound effects on metabolism. Insulin causes cells in the liver, muscle, and fat tissue to take up glucose from the blood, storing it as glycogen in the liver and muscle. When insulin is absent (or low), glucose is not taken up by body cells. for example, by transfer of lipids from adipose tissue to the liver for mobilization as an energy source. As its level is a central metabolic control mechanism, its status is also used as a control signal to other body systems (such as amino acid uptake by body cells). In addition, it has several other anabolic effects throughout the body. Insulin release is stimulated mainly by the conception of carbohydrates, certain amino acids, or the combination of both. Nevertheless In today's society The number of people who suffer from dysfunction in the insulin signaling cascade Are almost infinite.

As you can see from the above explanation this can cause a multitude of problems all of which ultimately lead to what non of us want. fat gain,muscle wasting,lose of strength and stamina.

Even better is the fact that we can see through manipulation of the signaling cascade,nutrient partitioning, and the use of Insulin mimicking compounds. Not only can people with pore nutrient signaling greatly benefit their quest for increased muscle and fat lose but even the most genetically gifted can reap the rewords. My friends there is room for everyone on this gravy train.

Now comes how!!! Need2slin, is NTBM'S Newest creation. Taking nutrient optimization,nutrient partitioning, and Insulin mimicking to new heights.

What's in Need2sline?
We put more of whats needed,Left out whats not, And as always opted adding in the more expensive ingredients over the cheap harmful ones. At NTBM we do it right or we don't do it at all.

1.) 450mg gymnema sylvestre, a whopping 75 percent gymnemic acids!!
2.) 250mg Acetyl L-carnatine
3.) 200mg NaR-ALA
4.) 200mg L-norvaline
5.) 90mg Coleus forskholi, 20 percent forskolin.
6.) 30mg synephrine HCI
7.) 18mg Banaba leaf.

How they work.


450mg gymnema sylvestre

What exactly does this do, whats the proof?

Use of Gymnema sylvestre leaf extract in the contr... [J Ethnopharmacol. 1990] - PubMed result (http://www.ncbi.nlm.nih.gov/pubmed/2259216)
http://www.ncbi.nlm.nih.gov/pubmed/2259217?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsP anel.Pubmed_SingleItemSupl.Pubmed_Discovery_RA&linkpos=1&log$=relatedarticles&logdbfrom=pubmed
A Major Scientific Breakthrough From Novel Gymnema Sylvestre Isolate Research May Provide A New Therapy For Type 2 Diabetes (http://www.medicalnewstoday.com/articles/145449.php)

These articles show it has outstanding therapeutic qualities, The hypoglycemic extract of Gymnema sylvestris brings about blood glucose homeostasis, which in turn prevents increased glycosylation of proteins thus reversing the onset of changes leading to micro and macroangiopathy. Control of Diabetes mellitus and the associated complications are mediated through the revival or regeneration of the insulin, producing beta-cells in the islets of langerhans. The glucose-like molecules in Gurmar known as the gymnemic acid fills the receptor locations in the absorptive external layers of the intestine, thereby preventing the intestine from absorbing the sugar molecules. Due to the change in the absorption level of sugar, there is a consequent change in the blood sugar level... This is the action from which it forces these sugars into muscle cells, these beta cells are the key to getting insulin to work the way we want, cellular recovery and repair.

Also it has outstanding health benefits.
What is Gymnema Sylvestre? (http://www.wisegeek.com/what-is-gymnema-sylvestre.htm),

So that is the first ingredient, this supplement called the Destroyer of sugar, allows beta cell regeneration, causing a response in healthy insulin. And a great aid in fat loss, or prevention of fat storage.

Next,

Acetyl L-carnatine, this is similar in form to the amino acid L-carnitine and also has some similar functions, such as being involved in the metabolism of food into energy. The acetyl group that is part of acetyl-L-carnitine contributes to the production of the neurotransmitter acetylcholine, which is required for mental function, and increased CNS function, so better performance, ideal for athletes. And it increases androgen receptor sensitivity, another reason why we included it in N2SLIN, androgen receptors attract testosterone which binds to them, increasing muscle size and mass, while increasing strength.
The arms and shoulders have a lot of androgen receptors, hence the reason why arms and shoulders can be lean when the stomach is fat, as the abdominal region contains lots of estrogen receptors, N2SLIN activates the androgen receptors, leading to a leaner more muscular look, and blocks fat from being stored.

Kraemer WJ, Spiering BA, Volek JS, Ratamess NA, Sharman MJ, Rubin MR, French DN, Silvestre R, Hatfield DL, Van Heest JL, Vingren JL, Judelson DA, Deschenes MR, Maresh CM. Androgenic responses to resistance exercise: effects of feeding and L-carnitine. Med Sci Sports Exer., 2006 Jul: 38(7): 1288-96.
23. Kraemer WJ, Volek JS, French DN, Rubin MR, Sharman MJ, Gómez AL, Ratamess NA, Newton RU, Jemiolo B, Craig BW, Häkkinen K. The effects of L-carnitine L-tartrate supplementation on hormonal responses to resistance exercise and recovery. J Strength Cond. Res. 2003 Aug: 17(3): 455-462

Acetyl-L-carnitine (http://www.lef.org/prod_hp/abstracts/php-ab028.html)


All those listed studies shows its numerous health benefits, its ability to repair neurons. But this is what we need it in N2SLIN for.

Eksp Klin Farmakol (RUSSIA) Jul-Aug 1992, 55 (4) p35-6


The study was undertaken to examine the effects of l-carnitine and acetyl-l-carnitine in rats and mice with experimental alloxan diabetes. The findings suggest that acetyl-l-carnitine is more effective against diabetes in increasing glucose tolerance, restoring the impaired response of glucagon to glucose, showing glycogen-sparing action than is l-carnitine.

Glucagon secretion increases when blood sugar levels are diminished, countering insulin's effects upon glucose and fat metabolism. One might expect that glucagon would have a negative paracrine action on ß-cells, but that is NOT the case. Glucagon does affect these insulin-secreting cells, but that effect is positive! That is, glucagon released between meals primes ß-cells so that they release INCREASED amounts of insulin WHEN GLUCOSE LEVELS RISE. Glucagon's action is coupled to production of a "second messenger" known as cyclic AMP or cAMP. Increased levels of cAMP are an important stimulating factor in insulin secretion. This seems to be the basic mechanism for a new class of drugs now coming in use for regulation of insulin secretion in diabetes type.

New Secretion of Insulinand Glucagon (http://www.medbio.info/Horn/Time%203-4/secretion_of_insulin_and_glucagon.htm#Recent_Devel opments_in_Intretin_Stimulation_of_Insulin_Secreti on_(November_2005)).

So far we get a better insulin response, and a better glucagon secretion, leading to increased glycogen storage, and less fat storage, INSULIN is so anabolic because insulin acts on cells thoughout the body to stimulate uptake, utilization and storage of glucose. The effects of insulin on glucose metabolism vary depending on the target tissue.

Physiologic Effects of Insulin (http://www.vivo.colostate.edu/hbooks/pathphys/endocrine/pancreas/insulin_phys.html)

So we want insulin, we need cAMP activation to improve insulin response, we need glucagon response in between meals to ensure healthy insulin secretion when eating.



And thats where the long lasting Alpha Liopic Acid, or in N2SLIN's case the most powerful version NaR-ALA, comes in,
Many natural nutrients such as Alpha Lipoic Acid, are engineered by nature to help your body's natural mechanisms control and maintain healthy blood sugar levels, to promote insulin secretion, stimulate glucose transport into cells, and to improve insulin sensitivity. They contain insulin potentiators--compounds known to increase the potency of insulin, binding insulin to cell membrane receptor sites. Antioxidants are important blood sugar regulators because high blood sugar causes oxidative stress, plus because it has a long halfe, NaR-ALA allows healthy blood sugar levels, and in between meals blood sugar levels drop, NaR-ALA is working all the time to keep them low, allowing Glucagon to stimulate beta cells, leading to a greater insulin response next time you eat.

Naturally Maintain Normal Blood Sugar Levels (http://www.janethull.com/newsletter/0608/naturally_maintain_normal_blood_sugar_levels.php)

Alpha Lipoic Acid & Diabetic Neuropathy (http://www.annieappleseedproject.org/noname66.html)

The last study shows its outstanding effect at lowering blood sugar in healthy individuals.


Next lets look at our orther insulin potentiator, Banaba leaf,
Banaba leaf extract supplement benefit and side effect : by Ray Sahelian, M.D. for blood sugar control and diabetes (http://www.raysahelian.com/banaba.html)

The blood sugar regulating properties of banaba have been demonstrated in cell culture, animal and human studies. In isolated cells, the active ingredient in banaba extract, corosolic acid, is known to stimulate glucose uptake. In diabetic mice, rats and rabbits, banaba feeding reduces elevated blood sugar and insulin levels to normal. In humans with type II diabetes, banaba extract, at a dose of 16-48mg per day for 4-8 weeks, has been shown to be effective in reducing blood sugar levels (5%-30% reduction) and maintaining tighter control of blood sugar fluctuations. An interesting “side-effect” of tighter control of blood sugar and insulin levels is a significant tendency of banaba to promote weight loss (an average of 2-4 lbs. per month) – without significant dietary alterations. It is likely that modulation of glucose and insulin levels reduces total caloric intake somewhat and encourages moderate weight loss.

Value:

As a dietary supplement to help reduce elevated levels of sugar and insulin in the blood, banaba extract has been shown to be safe and effective. As a weight loss aid, a handful of small (unpublished) studies in humans have suggested that tighter control of blood glucose and insulin can help promote moderate weight loss.


References:
1. Kakuda T, Sakane I, Takihara T, Ozaki Y, Takeuchi H, Kuroyanagi M. Hypoglycemic effect of extracts from Lagerstroemia speciosa L. leaves in genetically diabetic KK-AY mice. Biosci Biotechnol Biochem. 1996 Feb;60(2):204-8. 2. Murakami C, Myoga K, Kasai R, Ohtani K, Kurokawa T, Ishibashi S, Dayrit F, Padolina WG, Yamasaki K. Screening of plant constituents for effect on glucose transport activity in Ehrlich ascites tumour cells. Chem Pharm Bull (Tokyo). 1993 Dec;41(12):2129-31. 3. Suzuki Y, Unno T, Ushitani M, Hayashi K, Kakuda T. Antiobesity activity of extracts from Lagerstroemia speciosa L. leaves on female KK-Ay mice. J Nutr Sci Vitaminol (Tokyo). 1999 Dec;45(6):791-5

It also shows 5a reductase inhibition

The corosolic acid thus obtained has testosterone 5α-reductase inhibiting action, hair-papilla cell growth promoting action, fibroblast growth factor-7 (FGF-7) production promoting action, vascular endothelial growth factor (VEGF) production promoting action, or bone morphogenetic protein-2 (BMP-2) production promoting action, and hence can be used as a hair growth tonic, testosterone 5α-reductase inhibitor, hair papilla cell growth promoter, fibroblast growth factor-7 production promoter, vascular endothelial growth factor production promoter, or bone morphogenetic protein-2 production promoter that exploit such actions. The plant extract obtained by extraction, containing corosolic acid, can be used as-is as the effective ingredient of the hair growth tonic, testosterone 5α-reductase inhibitor, hair papilla cell growth promoter, fibroblast growth factor-7 production promoter, vascular endothelial growth factor production promoter, or bone morphogenetic protein-2 production promoter, but the plant extract is preferably used purified to a higher corosolic acid content. Using a plant extract with increased corosolic acid content allows obtaining a hair growth tonic, testosterone 5α-reductase inhibitor, hair papilla cell growth promoter, fibroblast growth factor-7 production promoter, vascular endothelial growth factor production promoter, or bone morphogenetic protein-2 production promoter that elicit yet more superior usage results. The plant extract containing corosolic acid can comprise an extract solution obtained using a plant containing corosolic acid, a diluted solution or concentrated solution of such extract solution, a dry product obtained by drying such extract solution, or a roughly purified or purified product of the foregoing

Read more: Hair Care Product - Patent application - With an object of discovering a substance having a testosterone 5 (http://www.faqs.org/patents/app/20090054522#ixzz0dcuT70Nh)

So even though it stimulates androgen receptors in the muscle it doesnt in the scalp, skin, or prostrate, making it ideal for women to use too.

Then we have the cAMP activators.

Synephrine HCI and Coleus are proven to stimulate the production of cyclic AMP (cAMP) from ATP. cAMP generation has a variety of effects on tissues, but the most notable is the stimulation of the thyroid to produce thyroxin, which promotes fat metabolization. The increased cAMP levels activate the protein kinase enzyme, which in turn activates hormone-sensitive lipase (HSL) in target tissues. cAMP also signals for the production of luteinizing hormone (LH), which has been shown to elevate testosterone levels in males. Elevated levels of cAMP and LH stimulate a marked increase in the use of fat as body fuel, and are strongly correlated to increased testosterone production,

Synephrine activates beta-3 adrenoreceptors and, therefore, displays a lipolytic and thermogenetic capacity as it boosts norepinephrine levels. By consuming synephrine prior to workouts, you enhance fat breakdown with its subsequent utilization for energy. Furthermore, synephrine has a significant muscle-sparing effect while expending energy at the expense of body fat, ideal if your trying to force feed muscles protein, and carbs, it in effect will be fueling your muscles with fat deposits to grow bigger and leaner, in combination with the other ingredients

McEwan DG, Brunton VG, Baillie GS, Leslie NR, Houslay MD, Frame MC. (June 2007) "Chemoresistant KM12C Colon Cancer Cells Are Addicted to Low Cyclic AMP Levels in a Phosphodiesterase 4-Regulated Compartment via Effects on Phosphoinositide 3-Kinase.", Cancer Research Volume 67, Issue 11.
^ Michael P. Godard, Brad A. Johnson, Scott R. Richmond (August 2005) "Body Composition and Hormonal Adaptations Associated with Forskolin Consumption in Overweight and Obese Men", Obesity Research Vol. 13 No. 8
Aaron H. Bubolz, Hongwei Li, Qingping Wu, and Yanping Liu. Enhanced oxidative stress impairs cAMP-mediated dilation by reducing Kv channel function in small coronary arteries of diabetic rats

Forskolin is a vasodilator.
To date, there have been more than two clinical studies examining the effectiveness of forskolin as a weight loss aid. Only one has been subject to peer-review and published in a medical journal. This clinical study also observed forskolin's role in significantly increasing lean mass, bone mass, and testosterone in the subjects involved. This research shows why we need it not only for its ability to activate cAMP, and that its a potent vasolidator, but it seems to block cortisol, and can boost natural hormone levels including thyroxin, wich is important for fat loss, and testosterone through stimulation of Leutinizing hormone.

What exactly is cAMP?

cAMP and its associated kinases function in several biochemical processes, including the regulation of glycogen, sugar, and lipid metabolism.

In humans, cyclic AMP works by activating protein kinase A (PKA, cAMP-dependent protein kinase). PKA is normally inactive as a tetrameric holoenzyme, consisting of two catalytic and two regulatory units (C2R2), with the regulatory units blocking the catalytic centers of the catalytic units. Cyclic AMP binds to specific locations on the regulatory units of the protein kinase, and causes dissociation between the regulatory and catalytic subunits, thus activating the catalytic units and enabling them to phosphorylate substrate proteins.

The active subunits catalyze the transfer of phosphate from ATP to specific serine or threonine residues of protein substrates. The phosphorylated proteins may act directly on the cell's ion channels, or may become activated or inhibited enzymes. Protein kinase A can also phosphorylate specific proteins that bind to promoter regions of DNA, causing increased expression of specific genes. Not all protein kinases respond to cAMP. Several classes of protein kinases, including protein kinase C, are not cAMP-dependent

Now why was ephedrine such a potent fat burner?
beta-receptors increase lipolysis, and ephedrine stimulated beta receptors, exactly the same way as synephrine does, so couple that with its ability to stimulate cAMP wich causes Lipolysis wich is the process of breaking down triglycerides into glycerol and fatty acids, and you have an awesome combo


You have in N2SLIN, Powerful insulin mimickers, but unlike real insulin the ingredients we use promote fat loss, and healthy blood glucose levels, thus stimulating glucagon to be released in between meals, thus supporting a healthier insulin response for type 2 diabetics as well as healthy fitness enthusiasts.

N2SLIN also as our studies show, stimulates androgen receptors, helping promote a leaner physique, it boosts natural testosterone production, leading to better strength gains and more muscle, and even better, less fat!
It stimulates the thyroid to release thyroxin, an important addition to help with fat loss, and improved lbm.

N2SLIN also increases cAMP activity, the bodies ability to breakdown fats for energy, and use them to build muscle, and increase glycogen storage. It also helps block cortisol, and provides an anabolic enviroment.

BEST OF ALL, the powerfull array of ingredients in N2SLIN shuttles the carbs you eat straight into the muscles, those carbs pull in water and proteins, and the fuel that the increased cAMP activation provides, all at the same time as stopping your body storing those carbs as fat, so think about it, bigger muscles, less fat.

N2SLIN is the strongest nutrient repartioner available!!

18mg of COROSOLIC acid (banaba)or Lagerstroemia Speciosa, as its called in P-slin,and Anabolic pump and 450mg of Gymnemic acids, add that to 200mg of NaR-ALA and you have the strongest INSULIN blend on the market, add the cAMP activators, and the energy regulating effects of,
250mg Acetyl L-carnatine
90mg Coleus forskholi, 20 percent forskolin.
30mg synephrine HCI,
and you have the most anabolic, fat burning blend available.

A complete all in one supplement,

Hormonal support
Fat burning
Fat blocking
Muscle building
Metabolism boosting
Energy releasing
Androgen receptor stimulation, but only in the muscle.
Increased igf-1 levels in the muscle, through enhanced nitrogen retention.

We even added a whopping 200mg of l-norvaline, 100mg more than slin-sane, L-Norvaline is an analog of the branched chain amino acid Valine, and it helps prevent the breakdown of arginine, by the enzyme arginase, so increasing nitric oxide, so increasing pumps, and vascularity, and most of all helping nitrogen retention, wich helps sustain the anabolic enviroment.

SBT
02-03-2010, 11:11 PM
Been using this about 3 weeks now and I am REALLY liking the results thus far!

needtogetaas
02-09-2010, 03:54 AM
Been using this about 3 weeks now and I am REALLY liking the results thus far!
So far the feed back has been popping up all over the net now. I love to see good feed back on forums I have never even seen pop up. Lets me know i am putting out good products that everyone can use and gain from.

"Rodz"
02-09-2010, 05:14 PM
Mine has been shipped!!!!!

Cant wait to KILL THAT SHIT!!!!!!!!!!!!!!!!!!!!!!!!!!!!!







http://www.needtobuildmuscle.net/reps/idevaffiliate.php?id=113 (http://www.needtobuildmuscle.net/reps/idevaffiliate.php?id=113)

51513

needtogetaas
02-11-2010, 05:16 AM
Nice sig man. You need to show me how to do that shit.

"Rodz"
02-11-2010, 11:27 PM
No prob man PM sent






http://www.needtobuildmuscle.net/reps/idevaffiliate.php?id=113 (http://www.needtobuildmuscle.net/reps/idevaffiliate.php?id=113)


51823

tammyp
02-12-2010, 08:06 AM
i cant wait to try this!

needtogetaas
02-16-2010, 10:17 PM
i cant wait to try this!
I got yours on the way girl

"Rodz"
02-16-2010, 10:40 PM
Wahoooo mine is at the border lol!!!!!!!!!!!!!!!

SBT
02-18-2010, 05:20 PM
well it will be there SOON then!! If it hasn't made it by now!

"Rodz"
02-18-2010, 07:59 PM
Just arrived today!!!!!!!!!!!!!!!!!!!!!!

SBT
02-20-2010, 12:01 PM
coool!! looking forward to seeing how you like it!

"Rodz"
02-23-2010, 10:45 PM
3 days in muscles are feelin really full, nice to have some carbs again!!

SBT
02-23-2010, 10:46 PM
3 days in muscles are feelin really full, nice to have some carbs again!!
heck yeah i am sure it is!! :yep:

"Rodz"
02-25-2010, 09:56 PM
heck yeah i am sure it is!! :yep:

It still feels a little weird eating them lololol

brandonp005
02-25-2010, 10:12 PM
I'm going to give this a run starting the end of March! I can't wait!!!!!!!!!!!

SBT
02-26-2010, 12:21 PM
I'm going to give this a run starting the end of March! I can't wait!!!!!!!!!!!

oh yeaaaa!!! I'll have to follow your log even more closely, but I think you'll see some nice progression with it!

wildcat22
02-28-2010, 08:32 PM
SBT what type of results are you noticing so far?

"Rodz"
03-01-2010, 01:31 AM
I'm going to give this a run starting the end of March! I can't wait!!!!!!!!!!!


Sounds good man, it is nice having the carbs utized to their fullest potential!!!

Conrad
03-01-2010, 01:31 PM
So what's the difference in Need2Slin and Novolin-R or etc...?

russianstar
03-02-2010, 02:48 PM
So what's the difference in Need2Slin and Novolin-R or etc...?

Check out the ingredient profile, there is a big difference, n2slin is the strongest nutrient repartioner around.

SBT
03-04-2010, 02:15 PM
I cannot say enough good things about this product!

Angel
03-04-2010, 09:56 PM
I have read so many, as well as keep track of so many peoples logs on this product. I enjoy reading about the progress that everyone is making!!

n2slin is an amazing product for sure.

SBT
03-06-2010, 02:51 PM
It sure is!! can't wait to start dieting in a couple weeks with this supplement in my corner!! :D

Angel
03-12-2010, 12:26 PM
It sure is!! can't wait to start dieting in a couple weeks with this supplement in my corner!! :D
So how is it going, are you dieting yet?

SBT
03-12-2010, 12:28 PM
So how is it going, are you dieting yet?

it's going AWESOME!! using the n2slin kept me JUST AS lean all through maintenance (which was pretty high cal/carb and had two weekly cheats) yet I stayed the same weight and leanness as when i dieted ALL of november and december!

dieting starts up next week, AFTER my birthday!!! :hbd:

Conrad
03-12-2010, 12:56 PM
I noticed Need2Slin keeping me lean so I am not bumping up my carbs. great product.

shrimp poboy
03-15-2010, 11:18 PM
Dont for get guys it works for gh as well,pm for discount codes!!!!!All I can say is need2' shit is the real deal!!!!

shrimp poboy
03-15-2010, 11:18 PM
upppppppp

fatbackgoal
03-16-2010, 11:21 AM
Going to give Need2 products a try and this will be the first thing.

Jason Newman
03-19-2010, 10:24 AM
Glucose management agents are some of m favorite type of supplements! gotta get me some of this, maybe next order....

gb4588
05-08-2010, 06:02 PM
Would using this on only refeed days or cheat meals have any value? or is this something that needs to be used everyday in order to work at all

brandonp005
05-08-2010, 11:07 PM
Would using this on only refeed days or cheat meals have any value? or is this something that needs to be used everyday in order to work at all


Yeah, I would like to know this as well!

Conrad
05-09-2010, 10:35 AM
Would using this on only refeed days or cheat meals have any value? or is this something that needs to be used everyday in order to work at all


Yeah, I would like to know this as well!
Yes, this product would aid in the assistance of a refeed day as well. However, I would opt for a higher dose since the amount of carbs on a refeed day would be much higher than a normal day. But I would not exceed 4 caps a day if you <150lbs.

But I am not sure why you would not just incase your overall calories throughout the week and take advantage of the purpose behind the product. It will shuttle more of the carbs and amino acids into the muscles rather than storing them as fat resulting in a leaner, harder look.

I would like for Mike or Nate to chime in and verify if I am correct or not. Thanks.

"Rodz"
05-09-2010, 11:16 AM
Yes, this product would aid in the assistance of a refeed day as well. However, I would opt for a higher dose since the amount of carbs on a refeed day would be much higher than a normal day. But I would not exceed 4 caps a day if you <150lbs.

But I am not sure why you would not just incase your overall calories throughout the week and take advantage of the purpose behind the product. It will shuttle more of the carbs and amino acids into the muscles rather than storing them as fat resulting in a leaner, harder look.

I would like for Mike or Nate to chime in and verify if I am correct or not. Thanks.

You make good points her Grip, and yes each cap is good for approx 50 carbs, so you guys can do the math, but it is hard to deny the effectiveness of the keto diet with weekly refeeds for fat loss, so trying them 30 min prior to refeeds is an interesting idea, gb4588, i'd love to hear the results of that, if you like the results you can experiment with your diet to increase the carbs and the Need2slin, you're the only one that will know what works for you.

Good Luck and Kill that Shit!!!

Jason Newman
05-24-2010, 11:09 PM
my favorite product in the whole line right here!!

SBT
05-25-2010, 08:25 PM
I know I have heard that it was excellent to use with refeeds as well, although I have yet to try that it has worked well with higher carb days that end in a cheat meal! :)

rahl
06-02-2010, 09:16 AM
Getting ready to use this for the second time. This time running alongside HCGenerate and Gear. Should be a fun June. :)

Jason Newman
06-02-2010, 05:15 PM
nice summer stack! im usuing it on cycle with turinabol LV to keep gains rock hard

Conrad
06-02-2010, 07:01 PM
Getting ready to use this for the second time. This time running alongside HCGenerate and Gear. Should be a fun June. :)
Keep us all update and post your comments about the service and products you recieve.

Also, join us on Facebook

http://www.facebook.com/?ref=home#!/pages/Need-To-Build-Muscle/122956891057899?ref=ts

SBT
06-02-2010, 10:32 PM
Getting ready to use this for the second time. This time running alongside HCGenerate and Gear. Should be a fun June. :)

looking forward to seeing how round two turns out for ya!!

Mad_Max21
06-05-2010, 10:05 PM
I made awesome gains with the slin will be a mainstay in my supps!

sweed
06-06-2010, 03:05 PM
Will be using again in about a month! :D

IslandGirl
06-12-2010, 01:15 AM
I'll be using slin for the first time. Stacking it with bridge and burner (Alpha Princess stack). So excited. I'll make sure to peek in and tell you guys how things are going. Also going to start up DC'ing again. Yeahhhhhh buddy!

sweed
06-16-2010, 04:45 PM
Will be using again in about a month! :D

looks like it was only 2 weeks! :p
KTS!!!

SBT
06-16-2010, 08:55 PM
looks like it was only 2 weeks! :p
KTS!!!

so why did you decide to add it in sooner?

SBT
06-16-2010, 08:55 PM
I'll be using slin for the first time. Stacking it with bridge and burner (Alpha Princess stack). So excited. I'll make sure to peek in and tell you guys how things are going. Also going to start up DC'ing again. Yeahhhhhh buddy!

Right there with ya girl!! :yep:

Shariff Abel
07-17-2010, 11:08 PM
just finished 2 bottles of need2slin awesome product incredible results!! wish i could try some other products too.

SBT
07-19-2010, 04:08 PM
that's great!! glad to hear it!! :D

fatbackgoal
07-21-2010, 04:23 PM
Running it with HCGenerate. I will be adding in Forged Burner to really look at shredding some pounds off.

data4
01-30-2013, 01:32 PM
I'll be using slin for the first time. Stacking it with bridge and burner (Alpha Princess stack). So excited. I'll make sure to peek in and tell you guys how things are going. Also going to start up DC'ing again. Yeahhhhhh buddy!

That sounds like an awesome combo. Bridge along with GEAR, N2Slin and a burner would be great

Young Gotti
02-08-2013, 09:43 AM
That sounds like an awesome combo. Bridge along with GEAR, N2Slin and a burner would be great

this is exactly my plan, probably around may or so

n2burn
n2slin
gear
bridge

data4
02-08-2013, 07:21 PM
this is exactly my plan, probably around may or so

n2burn
n2slin
gear
bridge

I have always like the combination of a good thermo and a GDA type supplement. Those along with the GEAR and Bridge should make for a nice cut with no muscle lose. Your weight may even stay the same while dropping fat.

Young Gotti
02-09-2013, 01:37 PM
I have always like the combination of a good thermo and a GDA type supplement. Those along with the GEAR and Bridge should make for a nice cut with no muscle lose. Your weight may even stay the same while dropping fat.

thats the goal....in theory it should work well

being 5ft 5 i cant afford to lose scale weight....then again i don't personally pay too much attention to my weight and more attention to what the mirror is telling me

data4
02-10-2013, 06:09 PM
thats the goal....in theory it should work well

being 5ft 5 i cant afford to lose scale weight....then again i don't personally pay too much attention to my weight and more attention to what the mirror is telling me

There are times I wish I was 5'5"!

mich29
10-08-2013, 12:03 AM
So what is need2slin?
Need2slin is a powerful Nutrition and carbohydrate shuttling
compound. It Shut guns carbohydrates and other nutrients To your muscles leaving them no chance of being stored as fat. By way of
increasing insulin (http://drugsprofiles.com/growth-hormone-and-peptides/insulin.html) sensitivity and carbohydrates/Nutrition up take Need2slin Improves Nutrition pertinence. This means carbs,sugars,fats other nutrients get used or stored in the muscle as energy rather then stared as fat. Moreover need2slin improves the dispelling of carbohydrates that are not used as well.

Now as if all this wasn't enough Needtobuildmuscle knows Our customers want more!! When hundreds of cheap products claim to do the same We at needtobuildmuscle always go the extra mile in our products. Simple we just like being flat out better then the rest.

So what else will one get from need2slin?

Well it does a variety of things that im sure you will find extremely exciting, if your looking for..

Increased LBM!

Rock hard, long lasting PUMPS!

Lower bodyfat!

Increased glycogen uptake!

Increased metabolism!

Improved thyroid function!

Increased Androgen receptor sensitivity!

Improved blood lipids

Increased vascularity

If these traits are desirable to you, then you neednt look any further, N2SLIN has arrived.
N2SLIN is a potent nutrient repartioner, it has a novel ingredient profile, it doesnt use cheaper alternatives, eg(berbarine) So it can be cycled all year round without pancreatic damage.

WHATS IT FOR?[b]

It can be used to increase lbm on a lean bulk, to increase strength, lower bodyfat, support good health, and to further gains in the gym.
Used 30 mins before meals, N2SLIN will push carbs into the muscles, giving you a food pump, it does this through 2 channels.

[B]FIRST.. Gymnema sylvestre, we will just call it G.S, pushes food into the muscle, as it mimicks insulin (http://drugsprofiles.com/growth-hormone-and-peptides/insulin.html), insulin (http://drugsprofiles.com/growth-hormone-and-peptides/insulin.html) is the most anabolic compound around, but VERY DANGEROUS!! Gymnema on the other hand has been proven to lower blood sugar levels, supporting lower cholesterol. And as a powerful insulin (http://drugsprofiles.com/growth-hormone-and-peptides/insulin.html) mimicker, it force feeds muscles with carbs, as the carbs are forced into muscle cells, the cells absorb..no infact they pull or suck water into their vicinity, along with vital nutrients, Protein (http://www.needtobuildmuscle.net/forum/../store/Protein-Products-c28/) and fats..all the building blocks muscles need, but what happens next?

SECOND.. Banaba leaf, 20 percent corosolic acid, works in a similar way, but with one big difference, it increases androgen receptor sensitivity, wich in turn increases localised IGF-1 (http://www.hardcoregrowth.com/products_igf_combo.html) in muscle tissue, IGF-1 (http://www.hardcoregrowth.com/products_igf_combo.html) is one of the most anabolic growth factors, helping tissue recovery, and growth, but also stimulating satelite cells in the muscle to start firing, meaning more muscle fibers!!! Bigger muscles!!
Also the increased androgen sensitivity means this..
Ever wondered why people can be fat with skinny arms? Because they have lots of androgen receptors in their arms, but in the belly lots of estrogen receptors, and these like to hold fat.
Well Banaba stimulates the ones that like to build muscle, and promote fat loss, and combined with Acetyl L-carnatine, they stimulate these receptors, and help change the bodies appearance over time.

A L-C also helps transport fat, to be used as energy, and not stored as fatty deposits, and where are all the nutrients being transported, to the muscle!!! So your depriving fat cells from being able to hold onto fat, and your feeding muscle cells everything they need to increase in size= less fat, more muscle!!!

Ok so what then?
Well have you heard of cAMP? Well real insulin (http://drugsprofiles.com/growth-hormone-and-peptides/insulin.html), actualy breaks down the enzyme that caused cAMP wich is why you can get fat if you were silly enough to use it, without going to scientific, cAMP is how your body metabolises fats to produce energy to feed muscles, increasing Protein (http://www.needtobuildmuscle.net/forum/../store/Protein-Products-c28/) metabolism in the process, so you get a greater metabolic rate, improved glycogen uptake, and increased Protein (http://www.needtobuildmuscle.net/forum/../store/Protein-Products-c28/) and fat synthesis. So all the calories you eat build muscle... that is if your training hard enough to stimulate the muscles to grow, And this process is carried out by Synephrine, one of the most powerful OTC cAMP stimulators available, and Coleus forskholi, wich also supports a healthy thyroid, and lowers the stress hormone cortisol, so increasing the anabolic enviroment, ideal for IGF-1 (http://www.hardcoregrowth.com/products_igf_combo.html) and cAMP to really get working!!
But how long does it work for?
G.S, and Banaba are very fast acting,Na R-Alpha lipoic acid, stays active for up to 6 hours, so think of it as a very powerfull but slow working G.S and Banaba combined, So you get this Anabolic window opened for up to 6 hours, 6 HOURS OF GROWTH!!!
As well as that Na R-Alpha lipoic acid is a very potent anti-oxidant and anti carcinogenic, so with the increased calories, and therfore the increase of toxins, you get a long lasting protection of oxidative stress on the human body.

That leaves us with just l-norvaline, at 200mg, that makes it very strong, L-norvaline boosts NO action, so increasing nitrogen retention, to add to the glycogen retention caused already, it increases blood flow, has been used to help with erectile function, and gives rock hard pumps!!!



GOOD, BUT HOW DO I USE IT?

2 caps 30 mins before a meal containing 40g carbs or more, this will shuttle the nutrients into the muscle, if you are on a big bulk, looking for large body mass increases, then 3 caps before a meal containing 60-100grams carbs.

N2SLIN will prevent any fat storage, but from the increased glycogen retention, and in turn as glycogen holds water, you may appear fatter, however if used for more than 6 weeks the effects of bodyfat decreasing, and muscle increasing will become very evident.
It can also be used before fasted cardio, to increase glut action, or the muscles ability to hold onto glycogen, and to boost gh (http://www.whatyouneedtoknowabouthgh.com/) secretion, by lowering blood sugar levels, plus its cortisol blocking effects will prevent catabolism of your hard earned muscle.

WHAT GAINS CAN I EXPECT?

Well depending on your diet and how well you use this, you could easily add a few lbs of lbm a month, and at the same time decrease bodyfat.

CAN I USE IT ON A CUT

Yes, it works very well, as it stops you from storing fat, but instead forces the nutrients to build muscle, use 1 cap before meals containing 10-20g carbs, 2 caps if 20-50.

Use one cap 3 times a day to lower cholesterol, and blood sugar levels, and elevate your bodies natural metabolism.

I will be providing a full meal and diet plan to get the most out of this very soon!!!

HOW LONG WILL IT LAST?

2 months at the reccomended dose.

CAN I STACK IT?

Its ideal to use with HCGenerate, and gear (http://www.needtobuildmuscle.net/forum/../store/Protein-Products/GEAR-p36.html), but can be used with creatine as both will gorge the muscles with nutrients, its great on a steroid or p/h cycle as it stops androgen receptors from being downgraded, and it can be used alone with good results.

Need2slin
2 caps per serving 60 servings per container.
1.) 450mg gymnema sylvestre, a whopping 75 percent gymnemic acids!!
2.) 250mg Acetyl L-carnatine
3.) 200mg NaR-ALA
4.) 200mg L-norvaline
5.) 90mg Coleus forskholi, 20 percent forskolin.
6.) 30mg synephrine HCI
7.) 18mg Banaba leaf.

awesome write up here.I had forgot about this one but with bulk season coming up n2slin should come in handy

Young Gotti
10-08-2013, 09:56 AM
awesome write up here.I had forgot about this one but with bulk season coming up n2slin should come in handy

i agree, n2slin could play a key role for someone looking to gain weight with increasing carbs but wanting to keep fat gain to a minimium

also like to add digestive enzymes in with n2slin to really help the body adjust to the increase in calories during the bulking season