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01-04-2012, 08:27 PM
J Clin Endocrinol Metab. (http://www.ncbi.nlm.nih.gov/pubmed/18559908#) 2008 Sep;93(9):3510-4. Epub 2008 Jun 17.
The type 5 phosphodiesterase inhibitor tadalafil influences salivary cortisol, testosterone, and dehydroepiandrosterone sulphate responses to maximal exercise in healthy men.
Di Luigi L (http://www.ncbi.nlm.nih.gov/pubmed?term=%22Di%20Luigi%20L%22%5BAuthor%5D), Baldari C (http://www.ncbi.nlm.nih.gov/pubmed?term=%22Baldari%20C%22%5BAuthor%5D), Sgrò P (http://www.ncbi.nlm.nih.gov/pubmed?term=%22Sgr%C3%B2%20P%22%5BAuthor%5D), Emerenziani GP (http://www.ncbi.nlm.nih.gov/pubmed?term=%22Emerenziani%20GP%22%5BAuthor%5D), Gallotta MC (http://www.ncbi.nlm.nih.gov/pubmed?term=%22Gallotta%20MC%22%5BAuthor%5D), Bianchini S (http://www.ncbi.nlm.nih.gov/pubmed?term=%22Bianchini%20S%22%5BAuthor%5D), Romanelli F (http://www.ncbi.nlm.nih.gov/pubmed?term=%22Romanelli%20F%22%5BAuthor%5D), Pigozzi F (http://www.ncbi.nlm.nih.gov/pubmed?term=%22Pigozzi%20F%22%5BAuthor%5D), Lenzi A (http://www.ncbi.nlm.nih.gov/pubmed?term=%22Lenzi%20A%22%5BAuthor%5D), Guidetti L (http://www.ncbi.nlm.nih.gov/pubmed?term=%22Guidetti%20L%22%5BAuthor%5D).
Source
Unit of Endocrinology, Department of Health Sciences, University of Rome Foro Italico, Piazza Lauro de Bosis, 15, 00194 Rome, Italy. [email protected]
Abstract
CONTEXT:
Physical exercise-related stress activates hypothalamus-pituitary-adrenal (HPA) axis; nitric oxide is one of the mediators of the HPA axis response to stress, and phosphodiesterase type 5 inhibitors influences nitric oxide-linked biological activities.
OBJECTIVE:
The objective of the study was to investigate whether a single oral long half-life phosphodiesterase type 5 inhibitor (tadalafil) administration influences the HPA axis response to exercise-related stress.
DESIGN:
This was a double-blind, cross-over trial.
PARTICIPANTS:
Participants included nine healthy male athletes.
INTERVENTIONS:
All subjects performed a maximal exercise test in normoxia, after which they received a single oral administration of tadalafil or placebo. Then after a 2-wk washout period, they were crossed over and repeated the exercise test. Each subject was his own control. Salivary collections, for steroid evaluations [cortisol, dehydroepiandrosterone sulphate (DHEAS), testosterone] and respective ratio calculation (DHEAS to cortisol, testosterone to cortisol, testosterone to DHEAS), were performed before each exercise (Pre-Ex), immediately after (Post-Ex), and at 30 min during recovery.
RESULTS:
As expected, mean salivary cortisol concentration increased immediately after exercise after both tadalafil and placebo (P = 0.014 and P =0.036 vs. Pre-Ex, respectively); however, the cortisol increase was significantly higher after tadalafil administration (P = 0.034 vs. placebo). Furthermore, an increased salivary testosterone after exercise was observed only after tadalafil administration (P = 0.029 vs. Pre-Ex). No effects of either exercise and/or tadalafil administration on salivary DHEAS concentrations were observed. DHEAS to cortisol and testosterone to cortisol ratios significantly decreased after exercise after tadalafil administration (P = 0.037, and P = 0.02 vs. placebo, respectively).
CONCLUSION:
Tadalafil administration amplified the salivary cortisol and testosterone responses to a maximal exercise-related stress in healthy trained humans.
PMID: 18559908
FFT (http://jcem.endojournals.org/content/93/9/3510.long)
The type 5 phosphodiesterase inhibitor tadalafil influences salivary cortisol, testosterone, and dehydroepiandrosterone sulphate responses to maximal exercise in healthy men.
Di Luigi L (http://www.ncbi.nlm.nih.gov/pubmed?term=%22Di%20Luigi%20L%22%5BAuthor%5D), Baldari C (http://www.ncbi.nlm.nih.gov/pubmed?term=%22Baldari%20C%22%5BAuthor%5D), Sgrò P (http://www.ncbi.nlm.nih.gov/pubmed?term=%22Sgr%C3%B2%20P%22%5BAuthor%5D), Emerenziani GP (http://www.ncbi.nlm.nih.gov/pubmed?term=%22Emerenziani%20GP%22%5BAuthor%5D), Gallotta MC (http://www.ncbi.nlm.nih.gov/pubmed?term=%22Gallotta%20MC%22%5BAuthor%5D), Bianchini S (http://www.ncbi.nlm.nih.gov/pubmed?term=%22Bianchini%20S%22%5BAuthor%5D), Romanelli F (http://www.ncbi.nlm.nih.gov/pubmed?term=%22Romanelli%20F%22%5BAuthor%5D), Pigozzi F (http://www.ncbi.nlm.nih.gov/pubmed?term=%22Pigozzi%20F%22%5BAuthor%5D), Lenzi A (http://www.ncbi.nlm.nih.gov/pubmed?term=%22Lenzi%20A%22%5BAuthor%5D), Guidetti L (http://www.ncbi.nlm.nih.gov/pubmed?term=%22Guidetti%20L%22%5BAuthor%5D).
Source
Unit of Endocrinology, Department of Health Sciences, University of Rome Foro Italico, Piazza Lauro de Bosis, 15, 00194 Rome, Italy. [email protected]
Abstract
CONTEXT:
Physical exercise-related stress activates hypothalamus-pituitary-adrenal (HPA) axis; nitric oxide is one of the mediators of the HPA axis response to stress, and phosphodiesterase type 5 inhibitors influences nitric oxide-linked biological activities.
OBJECTIVE:
The objective of the study was to investigate whether a single oral long half-life phosphodiesterase type 5 inhibitor (tadalafil) administration influences the HPA axis response to exercise-related stress.
DESIGN:
This was a double-blind, cross-over trial.
PARTICIPANTS:
Participants included nine healthy male athletes.
INTERVENTIONS:
All subjects performed a maximal exercise test in normoxia, after which they received a single oral administration of tadalafil or placebo. Then after a 2-wk washout period, they were crossed over and repeated the exercise test. Each subject was his own control. Salivary collections, for steroid evaluations [cortisol, dehydroepiandrosterone sulphate (DHEAS), testosterone] and respective ratio calculation (DHEAS to cortisol, testosterone to cortisol, testosterone to DHEAS), were performed before each exercise (Pre-Ex), immediately after (Post-Ex), and at 30 min during recovery.
RESULTS:
As expected, mean salivary cortisol concentration increased immediately after exercise after both tadalafil and placebo (P = 0.014 and P =0.036 vs. Pre-Ex, respectively); however, the cortisol increase was significantly higher after tadalafil administration (P = 0.034 vs. placebo). Furthermore, an increased salivary testosterone after exercise was observed only after tadalafil administration (P = 0.029 vs. Pre-Ex). No effects of either exercise and/or tadalafil administration on salivary DHEAS concentrations were observed. DHEAS to cortisol and testosterone to cortisol ratios significantly decreased after exercise after tadalafil administration (P = 0.037, and P = 0.02 vs. placebo, respectively).
CONCLUSION:
Tadalafil administration amplified the salivary cortisol and testosterone responses to a maximal exercise-related stress in healthy trained humans.
PMID: 18559908
FFT (http://jcem.endojournals.org/content/93/9/3510.long)