IronCrusher
05-25-2009, 12:22 AM
Forged Post Cycle
http://www.needtobuildmuscle.com/store.html?page=shop.product_details&flypage=flypage-ask.tpl&product_id=30&category_id=1
This product combines proven ingredients that boost testosterone, raise free test levels, and restore normal hormonal production.
Forged post cycle contains Bulgarian Tribulus (http://www.rxhealthdrugs.com/brand/287/25/tribelus-tribulus-terrestris) terrestris, 3,4-divanillyltetrahydrofuran, and Fenugreek
The first ingredients In forged post cycle is 3,4-divanillyltetrahydrofuran
This has been proven to raise your bodies free test. Within the human body is a globular protein called Sex Hormone Binding Globulin (SHBG). SHBG binds to male androgens such as testosterone, rendering that testosterone “inactive.” That is, it makes it impossible for testosterone to bind to the androgen receptor and stimulate muscle cell growth. This is not good for people coming off a cycle and trying to keep muscle gains,, SHBG naturally binds over 90% of your testosterone! Making what little test you have going into pct almost useless.
Forged post cycle utilizeses the highest 95% pure extract available today of a lignan contained in nettle root called 3,4-divanillyltetrahydrofuran. 3,4-divanillyltetrahydrofuran has a very strong binding affinity to SHBG, making it next to impossible for SHBG to bind with testosterone. What This does Is make every once of test in your body during pct count. As you are in the first stages of pct your test is always low. So making sure every drop of it is not wasted is crucial to recovery. Making the most of the test you have is important during the fist stages of pct when test is low, and it’s a known fact that shbg is at its highest at the end of most hormone cycles. So lowering shbg would only seem smart.
Interaction of lignans with human sex hormone binding globulin (SHBG).
Schottner M, Gansser D, Spiteller G.
Lehrstuhl Organische Chemie I, Universitat Bayreuth, Germany.
Lignans bind to sex hormone-binding globulin (SHBG). The lignan with the highest binding affinity is (+/-)-3,4-divanillyltetrahydrofuran. In a double Stobbe condensation--without use of protecting groups--a wide variety of lignans with different substitution pattern in the aromatic and aliphatic part of the molecule was synthesized. These lignans were tested in a SHBG-binding assay which allowed to deduce the following relationship between structure and activity: 1) (+/-)-diastereoisomers are more active than meso compounds 2.) the 4-hydroxy-3-methoxy (guajacyl) substitution pattern in the aromatic part is most effective 3.) the activity increases with the decline in polarity of the aliphatic part of the molecule.
Lignans from the roots of Urtica dioica and their metabolites bind to human sex hormone binding globulin (SHBG).
Schottner M, Gansser D, Spiteller G.
Lehrstuhl Organische Chemie I, Universitat Bayreuth, Germany.
Polar extracts of the stinging nettle (Urtica dioica L.) roots contain the ligans (+)-neoolivil, (-)-secoisolariciresinol, dehydrodiconiferyl alcohol, isolariciresinol, pinoresinol, and 3,4-divanillyltetrahydrofuran. These compounds were either isolated from Urtica roots, or obtained semisynthetically. Their affinity to human sex hormone binding globulin (SHBG) was tested in an in vitro assay. In addition, the main intestinal transformation products of plant lignans in humans, enterodiol and enterolactone, together with enterofuran were checked for their activity. All lignans except (-)-pinoresinol developed a binding affinity to SHBG in the in vitro assay. The affinity of (-)-3,4-divanillyltetrahydrofuran was outstandingly high These findings are discussed with respect to potential beneficial effects of plant lignans on benign prostatic hyperplasia (BPH).
The next ingredient in Forged post cycle is Bulgarian Tribulus (http://www.rxhealthdrugs.com/brand/287/25/tribelus-tribulus-terrestris) terrestris
Tribulus (http://www.rxhealthdrugs.com/brand/287/25/tribelus-tribulus-terrestris) Terrestris causes your body to release luteinizing
hormone, which in turn then signals your testicles to
naturally produce more testosterone. Studies have shown over 50% increase in testosterone levels when taking a pure form of Tribulus (http://www.rxhealthdrugs.com/brand/287/25/tribelus-tribulus-terrestris) Terresteris.
There has been much talk across the internet and on bodybuilding forums
About tribuluse and like anything everyone has there opinion. Some supplement companies clam it’s the greatest supplement ever and then some self proclaimed board gurus Claim its completely worthless.
Coming somewhere in the middle is the truth that Pure Tribulus (http://www.rxhealthdrugs.com/brand/287/25/tribelus-tribulus-terrestris) promotes recovery and aids in the pct process. Not only that but gives some added benefits like boosted sex drive and mood.
The 3rd proven ingredient in forged post cycle is Fenugreek
During a Designer supplement cycle it is always wise to use a liver sup (more on this later) but even after a cycle it is good to help the liver recover from the stress that you just put it threw. Your liver processes everything from Protein to estrogen. Every hormone is metabolized threw the liver. So Optamel liver function is of the utmost importance when coming off cycle. Repairing and rebuilding the liver after a harsh oral cycle is always a smart choice. Fenugreek has been proven to not only protect but (ready) repair liver damage
Alcohol Alcohol. 2006 May-Jun;41(3):267-73. Epub 2006 Mar 30. Links
Fenugreek (Trigonella foenum graecum) seed extract prevents ethanol-induced toxicity and apoptosis in Chang liver cells.Kaviarasan S, Ramamurty N, Gunasekaran P, Varalakshmi E, Anuradha CV.
Department of Biochemistry, Annamalai University, Annamalai Nagar, Tamil Nadu, India.
The protective effect of a polyphenolic extract of fenugreek seeds (FPEt) against ethanol (EtOH)-induced toxicity was investigated in human Chang liver cells. Cells were incubated with either 30 mM EtOH alone or together in the presence of seed extract for 24 h. Assays were performed in treated cells to evaluate the ability of seeds to prevent the toxic effects of EtOH. EtOH treatment suppressed the growth of Chang liver cells and induced cytotoxicity, oxygen radical formation and mitochondrial dysfunction. Reduced glutathione (GSH) concentration was decreased significantly (P < 0.05) while oxidized glutathione (GSSG) concentration was significantly elevated in EtOH-treated cells as compared with normal cells. Incubation of FPEt along with EtOH significantly increased cell viability in a dose-dependent manner, caused a reduction in lactate dehydrogenase leakage and normalized GSH/GSSG ratio. The extract dose-dependently reduced thiobarbituric acid reactive substances formation. Apoptosis was observed in EtOH-treated cells while FPEt reduced apoptosis by decreasing the accumulation of sub-G1 phase cells. The cytoprotective effects of FPEt were comparable with those of a positive control silymarin, a known hepatoprotective agent. The findings suggest that the polyphenolic compounds of fenugreek seeds can be considered cytoprotective during EtOH-induced liver damage.
PMID: 16574673 [PubMed - indexed for MEDLINE]
1: Pharmazie. 2007 Apr;62(4):299-304.Links
Fenugreek (Trigonella foenum graecum) seed polyphenols protect liver from alcohol toxicity: a role on hepatic detoxification system and apoptosis.Kaviarasan S, Anuradha CV.
Department of Biochemistry, Annamalai University, Annamalai Nagar, Tamil Nadu, India.
The present study investigates the hepatoprotective effect of fenugreek seed polyphenolic extract (FPEt) against ethanol-induced hepatic injury and apoptosis in rats. Chronic ethanol administration (6 g/kg/day x 60 days) caused liver damage that was manifested by the elevation of markers of liver dysfunction--aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), bilirubin and gamma-glutamyl transferase (GGT) in plasma and reduction in liver glycogen. The effects on alcohol metabolizing enzymes such as alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) were studied and found to be altered in the alcohol-treated group. Ethanol administration resulted in adaptive induction of the activities of cytochrome p450 (cyt-p-450) and cytochrome-b5 (cyt-b5) and reduction in cytochrome-c-reductase (cyt-c-red) and glutathione-S-tranferase (GST), a phase II enzyme. Further, ethanol reduced the viability of isolated hepatocytes (ex vivo) as assessed by the trypan blue exclusion test and increased hepatocyte apoptosis as assessed by propidium iodide staining (PI). Treatment with FPEt restored the levels of markers of liver injury and mitigated the alterations in alcohol metabolizing and detoxification enzymes and the electron transport component cytochrome-c reductase. Increased hepatocyte viability and reduced apoptotic nuclei were observed in FPEt-treated rats. These findings demonstrate that FPEt acts as a protective agent against ethanol-induced abnormalities in the liver. The effects of FPEt are comparable with those of a known hepatoprotective agent, silymarin.
PMID: 17484288 [PubMed - indexed for MEDLINE]
1: Cell Biol Toxicol. 2007 Apr 24 [Epub ahead of print] Links
Fenugreek seed (Trigonella foenum graecum) polyphenols inhibit ethanol-induced collagen and lipid accumulation in rat liver.Kaviarasan S, Viswanathan P, Anuradha CV.
Department of Biochemistry, Faculty of Science, Annamalai University, Annamalai Nagar, Tamil Nadu, 608 002, India, [email protected] ([email protected]) This e-mail address is being protected from spambots, you need JavaScript enabled to view it .
Chronic alcoholism is associated with fatty liver and fibrosis characterized by collagen accumulation. Seeds of fenugreek, an annual herb, are reported to possess hepatoprotective activity. The study aims to investigate the effects of fenugreek seed polyphenol extract (FPEt) on liver lipids and collagen in experimental hepatotoxic rats. Hepatotoxicity was induced in male albino Wistar rats by administrating ethanol (6 g/kg per day) for 30 days. Control rats were given isocaloric glucose solution. FPEt was co-administered with ethanol at a dose of 200 mg/kg per day for the next 30 days. Silymarin was used as a positive control. Ethanol treatment caused increase in plasma and liver lipids, together with alterations in collagen content and properties. Administration of FPEt to alcohol-fed rats significantly improved lipid profile and reduced collagen content, crosslinking, aldehyde content and peroxidation. The effects were comparable with that of silymarin. FPEt administration had a positive influence on both lipid profile and on the quantitative and qualitative properties of collagen in alcoholic liver disease. The protective effect is presumably due to the bioactive phytochemicals in fenugreek seeds.
PMID: 17453353 [PubMed - as supplied by publisher]
1: Phytother Res. 2003 Aug;17(7):737-43. Links
Protective effect of fenugreek (Trigonella foenum graecum) seeds in experimental ethanol toxicity.Thirunavukkarasu V, Anuradha CV, Viswanathan P.
Department of Biochemistry, Faculty of Science, Annamalai University, Annamalai Nagar, Tamil Nadu, India.
The study investigates the effect of aqueous extract of fenugreek seeds (Trigonella foenum graecum) on lipid peroxidation and antioxidant status in experimental ethanol toxicity in rats. The ability of the seed extract to prevent iron-induced lipid peroxidation in vitro was also investigated. Ethanol feeding for 60 days resulted in significant increases in the activities of serum aspartate transaminase, alanine transaminase and alkaline phosphatase. The levels of serum lipid hydroperoxides and thiobarbituric acid reactive substances in liver and brain were also significantly elevated. Significantly lower activities of superoxide dismutase, catalase, glutathione peroxidase, glutathione S-transferase and glutathione reductase were observed in liver and brain accompanied by depletion in glutathione, ascorbic acid and alpha-tocopherol concentrations. Activity of Ca(2+) ATPase in brain was significantly lowered. Simultaneous administration of aqueous extract of fenugreek seeds with ethanol prevented the enzymatic leakage and the rise in lipid peroxidation and enhanced the antioxidant potential. The seeds exhibited appreciable antioxidant property in vitro which was comparable with that of reduced glutathione and alpha-tocopherol. Further, histopathological examination of liver and brain revealed that, aqueous extract of fenugreek seeds could offer a significant protection against ethanol toxicity. Copyright 2003 John Wiley & Sons, Ltd.
PMID: 12916070 [PubMed - indexed for MEDLINE]
healthy glucose levels and healthy sugar metabolism By
assisting the pancreas in production of insulin
the active compounds 4-hydroxyisoleucine In of fenugreek is an amino acid derivative that assists the pancreas in production of insulin. Studies have shown 4-hydroxyisoleucine reduces fasting blood sugars and improves after-meal glucose tolerance significantly. 4-hydroxyisoleucine works by two separate mechanisms: It has a direct, stimulating effect on insulin production for those who wish to increase their glucose metabolism and helps to reduce glucose resistance and the uptake of glucose, thereby reducing overall blood glucose levels. Several studies with animals and with human cell cultures demonstrate this extract’s positive effect on reducing postmeal glucose levels—with little or no increase in blood insulin concentrations— a clear indictor of improved insulin sensitivity
Several studies show that the free amino acid 4-hydroxyisoleucine plays a valuable role in insulin-promotion and glucose regulation. 4-hydroxyisoleucine stimulates insulin secretion, thereby limiting the extent to which blood glucose (the glycemic index) is elevated. Elevated blood glucose after meals leads to increased production of body fat. 4 hydroxyisoleucine promotes insulin secretion and inhibits the rise of blood glucose, thus helping to reduce body fat production. 4 -hydroxyisoleucine exhibits a specific effect on the islets of Langerhans in the pancreas. These cells are directly responsible for insulin production. Most significantly, the effect of 4-hydroxyisoleucine is glucose dependent. The higher the level of blood glucose, the greater the insulin-promoting response elicited by 4 hydroxyisoleucine. Thus 4-hydroxyisoleucine exhibits a significant regulating effect, which corresponds with the insulin needs of the body at any given time. This makes this compound “adaptogenic,” responding to the particular needs of the body at any given time
And finely some studies of shown that fenugreek can raise the bodies natural testosterone
The last ingredients in forged post cycle are Indole-3-Carbinole and Chrysin. To reduce estrogen which is often elevated after a cycle of designer supplement. This ingredients of shown in many studies to effectively reduce estrogen levels
How to use forged liver support. The day your Designer supplement cycle ends start forged post cycle and run it 2 caps every day for 4 weeks.
http://www.needtobuildmuscle.com/store.html?page=shop.product_details&flypage=flypage-ask.tpl&product_id=30&category_id=1
http://www.needtobuildmuscle.com/store.html?page=shop.product_details&flypage=flypage-ask.tpl&product_id=30&category_id=1
This product combines proven ingredients that boost testosterone, raise free test levels, and restore normal hormonal production.
Forged post cycle contains Bulgarian Tribulus (http://www.rxhealthdrugs.com/brand/287/25/tribelus-tribulus-terrestris) terrestris, 3,4-divanillyltetrahydrofuran, and Fenugreek
The first ingredients In forged post cycle is 3,4-divanillyltetrahydrofuran
This has been proven to raise your bodies free test. Within the human body is a globular protein called Sex Hormone Binding Globulin (SHBG). SHBG binds to male androgens such as testosterone, rendering that testosterone “inactive.” That is, it makes it impossible for testosterone to bind to the androgen receptor and stimulate muscle cell growth. This is not good for people coming off a cycle and trying to keep muscle gains,, SHBG naturally binds over 90% of your testosterone! Making what little test you have going into pct almost useless.
Forged post cycle utilizeses the highest 95% pure extract available today of a lignan contained in nettle root called 3,4-divanillyltetrahydrofuran. 3,4-divanillyltetrahydrofuran has a very strong binding affinity to SHBG, making it next to impossible for SHBG to bind with testosterone. What This does Is make every once of test in your body during pct count. As you are in the first stages of pct your test is always low. So making sure every drop of it is not wasted is crucial to recovery. Making the most of the test you have is important during the fist stages of pct when test is low, and it’s a known fact that shbg is at its highest at the end of most hormone cycles. So lowering shbg would only seem smart.
Interaction of lignans with human sex hormone binding globulin (SHBG).
Schottner M, Gansser D, Spiteller G.
Lehrstuhl Organische Chemie I, Universitat Bayreuth, Germany.
Lignans bind to sex hormone-binding globulin (SHBG). The lignan with the highest binding affinity is (+/-)-3,4-divanillyltetrahydrofuran. In a double Stobbe condensation--without use of protecting groups--a wide variety of lignans with different substitution pattern in the aromatic and aliphatic part of the molecule was synthesized. These lignans were tested in a SHBG-binding assay which allowed to deduce the following relationship between structure and activity: 1) (+/-)-diastereoisomers are more active than meso compounds 2.) the 4-hydroxy-3-methoxy (guajacyl) substitution pattern in the aromatic part is most effective 3.) the activity increases with the decline in polarity of the aliphatic part of the molecule.
Lignans from the roots of Urtica dioica and their metabolites bind to human sex hormone binding globulin (SHBG).
Schottner M, Gansser D, Spiteller G.
Lehrstuhl Organische Chemie I, Universitat Bayreuth, Germany.
Polar extracts of the stinging nettle (Urtica dioica L.) roots contain the ligans (+)-neoolivil, (-)-secoisolariciresinol, dehydrodiconiferyl alcohol, isolariciresinol, pinoresinol, and 3,4-divanillyltetrahydrofuran. These compounds were either isolated from Urtica roots, or obtained semisynthetically. Their affinity to human sex hormone binding globulin (SHBG) was tested in an in vitro assay. In addition, the main intestinal transformation products of plant lignans in humans, enterodiol and enterolactone, together with enterofuran were checked for their activity. All lignans except (-)-pinoresinol developed a binding affinity to SHBG in the in vitro assay. The affinity of (-)-3,4-divanillyltetrahydrofuran was outstandingly high These findings are discussed with respect to potential beneficial effects of plant lignans on benign prostatic hyperplasia (BPH).
The next ingredient in Forged post cycle is Bulgarian Tribulus (http://www.rxhealthdrugs.com/brand/287/25/tribelus-tribulus-terrestris) terrestris
Tribulus (http://www.rxhealthdrugs.com/brand/287/25/tribelus-tribulus-terrestris) Terrestris causes your body to release luteinizing
hormone, which in turn then signals your testicles to
naturally produce more testosterone. Studies have shown over 50% increase in testosterone levels when taking a pure form of Tribulus (http://www.rxhealthdrugs.com/brand/287/25/tribelus-tribulus-terrestris) Terresteris.
There has been much talk across the internet and on bodybuilding forums
About tribuluse and like anything everyone has there opinion. Some supplement companies clam it’s the greatest supplement ever and then some self proclaimed board gurus Claim its completely worthless.
Coming somewhere in the middle is the truth that Pure Tribulus (http://www.rxhealthdrugs.com/brand/287/25/tribelus-tribulus-terrestris) promotes recovery and aids in the pct process. Not only that but gives some added benefits like boosted sex drive and mood.
The 3rd proven ingredient in forged post cycle is Fenugreek
During a Designer supplement cycle it is always wise to use a liver sup (more on this later) but even after a cycle it is good to help the liver recover from the stress that you just put it threw. Your liver processes everything from Protein to estrogen. Every hormone is metabolized threw the liver. So Optamel liver function is of the utmost importance when coming off cycle. Repairing and rebuilding the liver after a harsh oral cycle is always a smart choice. Fenugreek has been proven to not only protect but (ready) repair liver damage
Alcohol Alcohol. 2006 May-Jun;41(3):267-73. Epub 2006 Mar 30. Links
Fenugreek (Trigonella foenum graecum) seed extract prevents ethanol-induced toxicity and apoptosis in Chang liver cells.Kaviarasan S, Ramamurty N, Gunasekaran P, Varalakshmi E, Anuradha CV.
Department of Biochemistry, Annamalai University, Annamalai Nagar, Tamil Nadu, India.
The protective effect of a polyphenolic extract of fenugreek seeds (FPEt) against ethanol (EtOH)-induced toxicity was investigated in human Chang liver cells. Cells were incubated with either 30 mM EtOH alone or together in the presence of seed extract for 24 h. Assays were performed in treated cells to evaluate the ability of seeds to prevent the toxic effects of EtOH. EtOH treatment suppressed the growth of Chang liver cells and induced cytotoxicity, oxygen radical formation and mitochondrial dysfunction. Reduced glutathione (GSH) concentration was decreased significantly (P < 0.05) while oxidized glutathione (GSSG) concentration was significantly elevated in EtOH-treated cells as compared with normal cells. Incubation of FPEt along with EtOH significantly increased cell viability in a dose-dependent manner, caused a reduction in lactate dehydrogenase leakage and normalized GSH/GSSG ratio. The extract dose-dependently reduced thiobarbituric acid reactive substances formation. Apoptosis was observed in EtOH-treated cells while FPEt reduced apoptosis by decreasing the accumulation of sub-G1 phase cells. The cytoprotective effects of FPEt were comparable with those of a positive control silymarin, a known hepatoprotective agent. The findings suggest that the polyphenolic compounds of fenugreek seeds can be considered cytoprotective during EtOH-induced liver damage.
PMID: 16574673 [PubMed - indexed for MEDLINE]
1: Pharmazie. 2007 Apr;62(4):299-304.Links
Fenugreek (Trigonella foenum graecum) seed polyphenols protect liver from alcohol toxicity: a role on hepatic detoxification system and apoptosis.Kaviarasan S, Anuradha CV.
Department of Biochemistry, Annamalai University, Annamalai Nagar, Tamil Nadu, India.
The present study investigates the hepatoprotective effect of fenugreek seed polyphenolic extract (FPEt) against ethanol-induced hepatic injury and apoptosis in rats. Chronic ethanol administration (6 g/kg/day x 60 days) caused liver damage that was manifested by the elevation of markers of liver dysfunction--aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), bilirubin and gamma-glutamyl transferase (GGT) in plasma and reduction in liver glycogen. The effects on alcohol metabolizing enzymes such as alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) were studied and found to be altered in the alcohol-treated group. Ethanol administration resulted in adaptive induction of the activities of cytochrome p450 (cyt-p-450) and cytochrome-b5 (cyt-b5) and reduction in cytochrome-c-reductase (cyt-c-red) and glutathione-S-tranferase (GST), a phase II enzyme. Further, ethanol reduced the viability of isolated hepatocytes (ex vivo) as assessed by the trypan blue exclusion test and increased hepatocyte apoptosis as assessed by propidium iodide staining (PI). Treatment with FPEt restored the levels of markers of liver injury and mitigated the alterations in alcohol metabolizing and detoxification enzymes and the electron transport component cytochrome-c reductase. Increased hepatocyte viability and reduced apoptotic nuclei were observed in FPEt-treated rats. These findings demonstrate that FPEt acts as a protective agent against ethanol-induced abnormalities in the liver. The effects of FPEt are comparable with those of a known hepatoprotective agent, silymarin.
PMID: 17484288 [PubMed - indexed for MEDLINE]
1: Cell Biol Toxicol. 2007 Apr 24 [Epub ahead of print] Links
Fenugreek seed (Trigonella foenum graecum) polyphenols inhibit ethanol-induced collagen and lipid accumulation in rat liver.Kaviarasan S, Viswanathan P, Anuradha CV.
Department of Biochemistry, Faculty of Science, Annamalai University, Annamalai Nagar, Tamil Nadu, 608 002, India, [email protected] ([email protected]) This e-mail address is being protected from spambots, you need JavaScript enabled to view it .
Chronic alcoholism is associated with fatty liver and fibrosis characterized by collagen accumulation. Seeds of fenugreek, an annual herb, are reported to possess hepatoprotective activity. The study aims to investigate the effects of fenugreek seed polyphenol extract (FPEt) on liver lipids and collagen in experimental hepatotoxic rats. Hepatotoxicity was induced in male albino Wistar rats by administrating ethanol (6 g/kg per day) for 30 days. Control rats were given isocaloric glucose solution. FPEt was co-administered with ethanol at a dose of 200 mg/kg per day for the next 30 days. Silymarin was used as a positive control. Ethanol treatment caused increase in plasma and liver lipids, together with alterations in collagen content and properties. Administration of FPEt to alcohol-fed rats significantly improved lipid profile and reduced collagen content, crosslinking, aldehyde content and peroxidation. The effects were comparable with that of silymarin. FPEt administration had a positive influence on both lipid profile and on the quantitative and qualitative properties of collagen in alcoholic liver disease. The protective effect is presumably due to the bioactive phytochemicals in fenugreek seeds.
PMID: 17453353 [PubMed - as supplied by publisher]
1: Phytother Res. 2003 Aug;17(7):737-43. Links
Protective effect of fenugreek (Trigonella foenum graecum) seeds in experimental ethanol toxicity.Thirunavukkarasu V, Anuradha CV, Viswanathan P.
Department of Biochemistry, Faculty of Science, Annamalai University, Annamalai Nagar, Tamil Nadu, India.
The study investigates the effect of aqueous extract of fenugreek seeds (Trigonella foenum graecum) on lipid peroxidation and antioxidant status in experimental ethanol toxicity in rats. The ability of the seed extract to prevent iron-induced lipid peroxidation in vitro was also investigated. Ethanol feeding for 60 days resulted in significant increases in the activities of serum aspartate transaminase, alanine transaminase and alkaline phosphatase. The levels of serum lipid hydroperoxides and thiobarbituric acid reactive substances in liver and brain were also significantly elevated. Significantly lower activities of superoxide dismutase, catalase, glutathione peroxidase, glutathione S-transferase and glutathione reductase were observed in liver and brain accompanied by depletion in glutathione, ascorbic acid and alpha-tocopherol concentrations. Activity of Ca(2+) ATPase in brain was significantly lowered. Simultaneous administration of aqueous extract of fenugreek seeds with ethanol prevented the enzymatic leakage and the rise in lipid peroxidation and enhanced the antioxidant potential. The seeds exhibited appreciable antioxidant property in vitro which was comparable with that of reduced glutathione and alpha-tocopherol. Further, histopathological examination of liver and brain revealed that, aqueous extract of fenugreek seeds could offer a significant protection against ethanol toxicity. Copyright 2003 John Wiley & Sons, Ltd.
PMID: 12916070 [PubMed - indexed for MEDLINE]
healthy glucose levels and healthy sugar metabolism By
assisting the pancreas in production of insulin
the active compounds 4-hydroxyisoleucine In of fenugreek is an amino acid derivative that assists the pancreas in production of insulin. Studies have shown 4-hydroxyisoleucine reduces fasting blood sugars and improves after-meal glucose tolerance significantly. 4-hydroxyisoleucine works by two separate mechanisms: It has a direct, stimulating effect on insulin production for those who wish to increase their glucose metabolism and helps to reduce glucose resistance and the uptake of glucose, thereby reducing overall blood glucose levels. Several studies with animals and with human cell cultures demonstrate this extract’s positive effect on reducing postmeal glucose levels—with little or no increase in blood insulin concentrations— a clear indictor of improved insulin sensitivity
Several studies show that the free amino acid 4-hydroxyisoleucine plays a valuable role in insulin-promotion and glucose regulation. 4-hydroxyisoleucine stimulates insulin secretion, thereby limiting the extent to which blood glucose (the glycemic index) is elevated. Elevated blood glucose after meals leads to increased production of body fat. 4 hydroxyisoleucine promotes insulin secretion and inhibits the rise of blood glucose, thus helping to reduce body fat production. 4 -hydroxyisoleucine exhibits a specific effect on the islets of Langerhans in the pancreas. These cells are directly responsible for insulin production. Most significantly, the effect of 4-hydroxyisoleucine is glucose dependent. The higher the level of blood glucose, the greater the insulin-promoting response elicited by 4 hydroxyisoleucine. Thus 4-hydroxyisoleucine exhibits a significant regulating effect, which corresponds with the insulin needs of the body at any given time. This makes this compound “adaptogenic,” responding to the particular needs of the body at any given time
And finely some studies of shown that fenugreek can raise the bodies natural testosterone
The last ingredients in forged post cycle are Indole-3-Carbinole and Chrysin. To reduce estrogen which is often elevated after a cycle of designer supplement. This ingredients of shown in many studies to effectively reduce estrogen levels
How to use forged liver support. The day your Designer supplement cycle ends start forged post cycle and run it 2 caps every day for 4 weeks.
http://www.needtobuildmuscle.com/store.html?page=shop.product_details&flypage=flypage-ask.tpl&product_id=30&category_id=1