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  1. RS, It is funny that you bring up the subject of...

    RS,
    It is funny that you bring up the subject of acromegaly and its association with gh and igf. I just completed a month intense focus area on this subject. Various tissue types express igf...
  2. Thank you and I don't know how a thread becomes a...

    Thank you and I don't know how a thread becomes a "sticky" so I cannot answer that question for you.
  3. You are welcome. And yes infertility is a...

    You are welcome. And yes infertility is a complex issue that presents problems to the provider and patient alike.
  4. RS, I follow what you are saying and I agree...

    RS,
    I follow what you are saying and I agree that the whole picture needs to be addressed if hyperplasia is ever to be had and proven. I guess I have been somewhat indoctrinated by the field of...
  5. RS, I will message you all of my references as I...

    RS, I will message you all of my references as I do not want to take up more room on this thread and for those who would like the references message me and i will send them to you as well.
  6. Growth hormone (GH) and insulin-like growth...

    Growth hormone (GH) and insulin-like growth factor I (IGF-I) have a key role in the regulation of body size in growing animals but their role in adults is less clear. IGF-I clearly has anabolic...
  7. RS, thank you for your reply, I am following...

    RS, thank you for your reply, I am following your rationale completely. However, I cannot find anything whether it be forum or literature that shows evidence at this present time that we have been...
  8. I just wanted to state that the above is just a...

    I just wanted to state that the above is just a guide to help readers understand what their doctor will do. it is not meant to be used for self diagnosis or self treatment of infertility. it is for...
  9. Replies
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    please see my write up i decided to go ahead and...

    please see my write up i decided to go ahead and do as a new thread labeled "COMPLETE DIAGNOSIS AND TREATMENT OF INFERTILITY related to AAS" to answer this question as well as the other questions...
  10. COMPLETE DIAGNOSIS AND TREATMENT OF INFERTILITY r/t AAS. Hope this helps understanding

    Male causative factors of infertility are classified into 5 categories:
    1. Endocrine

    2. Spermatogenesis
    3. Sperm antibodies
    4. Sperm transport
    5. Disorders...
  11. Replies
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    2,783

    Follicular stimulating hormone secretion from the...

    Follicular stimulating hormone secretion from the anterior pituitary is the key ingredient in the hypothalamic pituitary testicular axis. Exogenous use of testosterone replacement therapy aka AAS...
  12. you quoted this study: A PGC-1α isoform induced...

    you quoted this study:
    A PGC-1α isoform induced by resistance training regulates skeletal muscle hypertrophy. Cell. 2012 Dec 7;151(6):1319-31. doi: 10.1016/j.cell.2012.10.050
    in regards to the...
  13. in regards to igf-ir: "IGF-I and its receptor...

    in regards to igf-ir:

    "IGF-I and its receptor IGF-IR are seen as critical effectors of muscle hypertrophy, a notion recently questioned. Using MKR transgenic mice that express a dominant...
  14. igf does produce hypertrophy that is proven, it...

    igf does produce hypertrophy that is proven, it has not however been proven that igf produces hyperplasia. real world experience demonstrates this in the numerous amount of research trials that have...
  15. russianstar, what is the name of the unique...

    russianstar,
    what is the name of the unique pathway you speak of? i am very interested to see this myself. unfortunately the research i have seen indicates this is not the case at all. please...
  16. bryan, actually in medicine we do use the terms...

    bryan, actually in medicine we do use the terms synergy, potentiation, and additive effect. An example of this is the combination of meperidine (demerol) and (phenergan). A major side of...
  17. Replies
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    Thank you bryan for your response. Sorry if i...

    Thank you bryan for your response. Sorry if i came across as trying to fish for something. I guess I have seen so many different peptide companies come and go and I have seen such a wide variety...
  18. Replies
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    true if someone is taking all of the above than...

    true if someone is taking all of the above than no need to worry about negative feedback loop but for those that might be taking peptides for stimulation of natural release it needs to be taken into...
  19. Replies
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    of note, the potential life threatening...

    of note, the potential life threatening situations that arise from insulin use in both the diabetic and non diabetic cannot be emphasized enough. that being said, when considering the question of pre...
  20. Replies
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    I would be interested to know (and it doesn't...

    I would be interested to know (and it doesn't have to be posted on the forum, i would welcome a pm response) what kind of background you guys have in terms of science? I have an extensive...
  21. I would be interested to know (and it doesn't...

    I would be interested to know (and it doesn't have to be posted on the forum, i would welcome a pm response) what kind of background you guys have in terms of science? I have an extensive...
  22. Replies
    34
    Views
    3,755

    I would be interested to know (and it doesn't...

    I would be interested to know (and it doesn't have to be posted on the forum, i would welcome a pm response) what kind of background you guys have in terms of science? I have an extensive background...
  23. Replies
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    876

    polycythemia which is an increase in the number...

    polycythemia which is an increase in the number of red blood cells increases blood viscosity. This is potentially dangerous b/c it impairs circulation and places one at risk for the development of a...
  24. another issue that people should be aware of is...

    another issue that people should be aware of is that there are many igf receptors in the intestinal tract and thus long term chronic administration of igf will cause hypertrophy of the smooth muscle...
  25. J Physiol....

    J Physiol. 2005 Oct 1;568(Pt 1):229-42. Epub 2005 Aug 4.
    Isolation and validation of human prepubertal skeletal muscle cells: maturation and metabolic effects of IGF-I, IGFBP-3 and TNFalpha.
    ...
  26. i wish it did but IGF DOES NOT cause skeletal muscle cell hyperplasia

    I would like to post some information in regards to what I have seen in many forums about the effect of igf on adult skeletal muscle tissue. i haven't been online in awhile b/c i'm so busy with...
  27. Unfortunately, the debate on igf in adult...

    Unfortunately, the debate on igf in adult skeletal muscle tissue is ongoing. Cell hyperplasia (additional myotube formation) has not been demonstrated with exogenous administration of IGF or its...
  28. read my reply to s2h in regards to your question

    read my reply to s2h in regards to your question
  29. The reason for this is that hyperglycemia and...

    The reason for this is that hyperglycemia and ingestion of food stimulates the hypothalamus and digestive organs to release somatostatin which in turn inhibits pituitary release of growth hormone....
  30. I have 1.5 years left of supervised rotations...

    I have 1.5 years left of supervised rotations before I can practice independently. so for the sake of my licensing, i want to state explicitly that i am not claiming to be a medical professional. ...
  31. Joe D, the symptoms you are describing are...

    Joe D, the symptoms you are describing are indicative of a possible pituitary adenoma. I don't know if this may have already been brought up by the physician who is prescribing your androgen therapy...
  32. I know that i have read previously where you had...

    I know that i have read previously where you had indicated that you are on a script for testosterone replacement therapy as a result of long term external androgen use, so get ur LH and FSH levels...
  33. Joe D low growth hormone situation possible causes and explanations

    JOE d - if you are not producing or releasing growth hormone, then it would be an issue with your anterior pituitary gland or your hypothalamus however, a quick check of the secondary glands which...
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