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  1. #496

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    Pharmacokinetics and Pharmacodynamics of Nandrolone Esters in Oil Vehicle: Effects of Ester, Injection Site and Injection Volume

    We studied healthy men who underwent blood sampling for plasma nandrolone, testosterone and inhibin measurements before and for 32 days after a single i.m. injection of 100 mg of nandrolone ester in arachis oil. Twenty-three men were randomized into groups receiving nandrolone phenylpropionate (group 1, n = 7) or nandrolone decanoate (group 2, n = 6) injected into the gluteal muscle in 4 ml of arachis oil vehicle or nandrolone decanoate in 1 ml of arachis oil vehicle injected into either the gluteal (group 3, n = 5) or deltoid (group 4,n = 5) muscles. Plasma nandrolone, testosterone and inhibin concentrations were analyzed by a mixed-effects indirect response model. Plasma nandrolone concentrations were influenced (P < .001) by different esters and injection sites, with higher and earlier peaks with the phenylpropionate ester, compared with the decanoate ester. After nandrolone decanoate injection, the highest bioavailability and peak nandrolone levels were observed with the 1-ml gluteal injection. Plasma testosterone concentrations were also influenced (P < .001) by the ester and injection site, with the most rapid, but briefest, suppression being due to the phenylpropionate ester, whereas the most sustained suppression was achieved with the 1-ml gluteal injection. Plasma inhibin concentrations were also significantly influenced by injection volume and site, with the lowest nadir occurring after the nandrolone decanoate 1-ml gluteal injection. Thus, the bioavailability and physiological effects of a nandrolone ester in an oil vehicle are greatest when the ester is injected in a small (1 ml vs. 4 ml) volume and into the glutealvs. deltoid muscle. We conclude that the side-chain ester and the injection site and volume influence the pharmacokinetics and pharmacodynamics of nandrolone esters in an oil vehicle in men.

  2. #497

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    The effect of heat on amino acids for growing pigs. 4. Nitrogen balance and urine, serum and plasma composition of growing pigs fed on raw or heat-treated field peas (Pisum sativum).

    Experiments were conducted to determine the effect of heating field peas (Pisum sativum) on the N balance and urine, serum and plasma composition of growing pigs. In the first experiment, four diets containing raw field peas (cv. Wirrega) or field peas heated to 150 degrees (cv. Wirrega), 165 degrees (cv. Wirrega) or 150 degrees (cv. Dundale) for 15 min respectively were formulated to contain 1.15 g ileal digestible N/MJ digestible energy (DE) and 0.36 g ileal digestible lysine/MJ DE in a sugar-based diet. Digestibility estimates were based on those for the Dundale cultivar of field peas used in previous experiments. Total urine and faeces collection from eight pigs was conducted over two 7 d collection periods with a 7 d diet change-over period. Serial blood sampling from the external jugular vein was conducted on the final day of each collection period. There was no significant difference (P > 0.05) in the N balance or apparent biological value of the field-pea treatments. Pigs fed on diets containing peas heated to 150 degrees (cv. Wirrega) or 165 degrees (cv. Wirrega) had a significantly lower (P < 0.01) daily output of urea and uric acid in the urine, and depressed serum protein and serum urea concentrations. Plasma lysine concentration and daily urine lysine output were not significantly different (P > 0.05) in pigs fed on heated peas. Protein excretion in the urine of pigs fed on diets containing peas heated to 165 degrees increased 3-7 times (depending on estimation technique) the level observed in pigs fed on diets containing raw peas. A second experiment was conducted to determine the apparent ileal digestibility of N and amino acids in cv. Wirrega field peas. This study revealed that N digestibility (0.44) and lysine digestibility (0.35) in peas heated to 165 degrees were significantly lower than the cv. Dundale estimates (0.57 and 0.62 respectively) used in diet formulations. The depressed serum and urine variables in pigs fed on heated peas were attributed to overestimation of digestibility. The results exemplify the fact that it is not possible to draw general conclusions as to the effects of heat on any particular protein concentrate. Variability in N balance experiments and problems associated with urine analysis are suggested as likely reasons for the current study not reflecting poor utilization of ileal digestible lysine from heat-treated field peas.

  3. #498

  4. #499

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    Day 6: Back, Chest, Delts, Abs

    ***WARM UP***
    Upperbody PAP Movements


    THIS IS MY WORLD! TIME TO BUILD MY EMPIRE!

    Overhand Barbell Rows Timed (strapped, thumbless grip): 3 sets of 40-70s
    145 x 45s
    145 x 45s
    145 x 45s


    Incline Barbell Bench: 3 sets of 40-70s
    145 x 45s
    145 x 45s
    145 x 45s


    FEEL THIS PAIN! FORCE THIS TENSION!

    Seated Military Press (pin lvl 10 showing): 3 sets of 12-20 reps
    Delt active ROM
    30 ps x 12
    30 ps x 12
    30 ps x 12


    Ultra WG Pullups ss DB Shrugs (strapped): 3 sets to failure
    BW x 12 into 125's x 40
    BW x 12 into 125's x 40
    BW x 12 into 125's x 40


    MY INSANITY SPREADS GROWTH LIKE FIRE!!!

    Pec Deck Flys: 3 sets of 40-70s
    Neutral Grip Timed (over emphasize fully lengthened stretch)
    165 x 50s
    165 x 50s
    165 x 50s


    Timed side lateral Crossed Cables: 3 sets
    Single (60-120s)
    5 x 1m 20s
    Both (40-60s)
    10 x 40s
    10 x 40s


    GO IF YOU WANT TO! THIS SH*T ISNT FOR THE WEAK!

    HS High Rows (Both arms alt): 4 sets
    Underhand
    1 pps x 10
    1 pps x 10
    Neutral
    1 pps x 10
    1 pps x 10


    Rear delt high row (using 2 single handles on lat pulldown): 4 sets
    40 x 12
    40 x 12
    40 x 12
    40 x 12


    HEAR MY ROOOOAR!!!

    Pec deck rear delt (arms slightly bent) ss cable flys (top down): 3 set constant circuit
    4:0:1:0 tempo
    150 x 20 into 25 x 20
    150 x 20 into 25 x 20
    150 x 20 into 25 x 20


    Underhand pulldowns ss rope pullovers: 4 sets
    Seated Paulo style
    145 x 10 into 42.5 x 8
    145 x 10 into 42.5 x 8
    145 x 10 into 42.5 x 8
    150 x 8 into 42.5 x 8


    SLASH! RIP! TEAR! KILL!

    K Style DB Side lateral ss cable (12-30 reps, LF into SF): 3 sets
    75's x 15 into 5 x 20
    75's x 15 into 5 x 20
    75's x 15 into 5 x 20


    BB behind the back shrugs: 2 sets of 60-120s timed
    Fully shortened fully lengthened exaggerated ROM
    155 x 1m 20s
    155 x 1m 20s


    WATCH ME SET THIS WORLD ON FIRE!

    Mid/Upper Chest Cable Fly (palms facing) ss seated machine side laterals: 2 timed sets of 60-120s
    20 x 1m into 90 x 1m 10s
    20 x 1m into 90 x 1m 10s


    Cable Fly (decline) ss rope face pulls: 2 sets
    0:0:0:2 tempo
    10 x 14 into 47.5 x 20
    10 x 14 into 47.5 x 20


    SCREAM OUT IN PAIN!!! LOUDER!!!

    ***Extreme Stretching***
    A1. Rope Pullover (82.5 x 45s)
    A2. Flat DB (60's x 45s)


    ***Daily Weak Point Cell Swelling Work***
    A1. overhand curl bar pressdowns (35 x 200)
    A2. curl bar curls (20 x 200)
    A3. seated machine (80 x 200)


    Vacuums: 1 set
    60s


    F@$KING GROW!!!! I WAS MADE FOR THIS!!!!

    Cable crunches: 4 sets to failure
    12-30 reps
    72.5 x 18
    72.5 x 18
    40-70s
    52.5 x 44s
    52.5 x 44s


    Twisting side cable crunches: 3 timed sets
    42.5 x 50s
    42.5 x 50s
    42.5 x 50s


    EVERY SECOND, EVERY REP, EVERY. F&)KING. DAY IS A CALL TO ARMS...WILL YOU ANSWER?

    Postworkout Cooldown
    Vacuums
    15 minutes Hydro Massage Table


    Later on During the Day
    Full Body Foam Rolling
    60 minutes Deep Tissue Massage Chair
    Calf & Trap Cell Swelling Work
    Sequential Compression Device
    Inversion Table

  5. #500

    Default

    Nitrogen metabolism in cockerels treated with 17-α-methyl-17-β-hydroxyandrosta-Δ1, 4-3-one (methandrostenolone)


    Intramuscular administrations of a saline suspension of 17-α-methyl-17-β-hydroxyandrosta-Δ1, 4-3-one (methandrostenolone) ranging from 0.25 to 10 mg per kilogram body weight per day were given to noncastrated White Rock cockerels from the fifth to the seventh week of age. It was found that the anabolic response to this steroid in chicks was similar to that of other androgens. Excessive dosages (1.25 mg per kilogram per day) resulted in slower gains in body weight, while moderate dosages (0.50 mg per kilogram per day) produced small but significant increases in weight over saline-injected controls. Although not as clearly defined, a similar pattern was observed in retention of nitrogen. Pectoralis muscle weights were depressed with 2.50 mg per kilogram per day while 5.00 mg per kilogram per day was required to reduce semi-membranosus weights. In general these reductions in muscle mass by excessive administration of the steroid could be accounted for by the lower body weights; however, the reductions in pectoralis weight at the 10 mg per kilogram per day dose level were greater than could be accounted for by correction for the lower body weight. Concentration of nitrogen in muscle or the percentage of water were not significantly changed at the dosages employed. Levels of the hormone sufficient to induce significant gains in weight and nitrogen retention also caused noticeable changes in sexual characteristics, including increased comb weight and maturation of the germinal epithelium within the seminiferous tubules.

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