Hi all I thought I'd share with you my latest research on bodybuilding supplements: Citrulline Malate Fails to Improve German Volume Training Performance in Healthy Young Men and Women. Full citation below.

Andrew J. Chappell, Daniel M. Allwood & Trevor N. Simper (2018) Citrulline Malate Fails to Improve German Volume Training Performance in Healthy Young Men and Women, Journal of Dietary Supplements, DOI: 10.1080/19390211.2018.1513433

This is the second paper myself and my colleagues have published this year investigating the effects of citrulline malate on resistance training performance using a bodybuilding protocol. The results of this investigation were similar to the trial we published in the JISSN earlier this year which you can read here:

I've included the abstract below, the full text can be accessed via my ResearchGate profile. If anyone has any questions i would be happy to take them. However to cut a long story short we didn't manage to find anything when we tested this supplement against a placebo. Our work on this supplement however is currently ongoing. I'm honestly not sure if the supplement works or not, or may be we've just not tested it in the right sort of people, using the correct design. If there is an effect, I expect it's minimal. What do you all think though? Do any of you guy's use this stuff?


Citrulline malate (CM) is purported to buffer lactic acid, enhance oxygen delivery, and attenuate muscle soreness. Anaerobic exercise trials with CM have produced conflicting results. The aim of the current investigation was to test the efficacy of CM on resistance training (RT) with the hypothesis that CM would improve performance. A double-blind, counter-balanced, randomized control trial was utilized to assess the effects of CM on RT. Nineteen participants (8 female) (25.7 ± 7.7 years), regularly engaged in RT, consumed either 8 g of CM (1.1:1 ratio) or a placebo (6 g citric acid). Participants attempted to perform a German Volume Training (GVT) protocol comprising 10 sets of 10 repetitions of barbell curls at 80% of their one repetition maximum. Repeated ANOVA suggested no effect of CM on RT performance (treatment × time × order p = .217). There was no difference (p = .320) in the total number of reps over the 10 sets (CM median = 57, IQR 45–73; placebo median = 61, IQR 51–69). Blood lactate and creatine kinase did not differ between CM and placebo (p > .05). Finally, total muscle soreness was reduced significantly in CM compared to placebo (treatment × time × order p = .004). These results require corroboration; an ergogenic benefit is yet to be established, and weight trainers should exercise caution when assessing the efficacy of CM. Future research should focus on the potential effects of loading doses of CM.