Folic Acid / {beta}-Adrenoceptors

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Exp Biol Med (Maywood). 2009 Jul 13. [Epub ahead of print] Links

Folic Acid Supplementation Modifies {beta}-Adrenoceptor-Mediated in vitro Lipolysis of the Obese/Diabetic (+db/+db) Mice.

Lam TY, Seto SW, Au AL, Poon CC, Lam AH, Lau MW, Chan SW, Ngai SM, Leung GP, Lee SM, Tsui SK, Kwan YW.
The Chinese University of Hong Kong.
The effects of folic acid (5.7 and 71 microg/kg), 4 weeks) consumption on the beta-adrenoceptors (beta-ARs)-elicited lipolysis in vitro of the abdominal adipocytes of the lean/control (+m/+db) and obese/diabetic (+db/+db) mice (female) were investigated. beta-AR agonists (salbutamol, a beta2-AR agonist; BRL 37344 and CGP 12177, beta3-AR agonists; adrenaline, a beta-AR agonist)-mediated lipolysis, beta2 and beta3-ARs protein expression of the adipose tissues after folic acid consumption were evaluated. Our results demonstrate that a smaller magnitude of the basal (spontaneous) and the beta-AR agonists-triggered lipolysis was observed in +db/+db mice, and folic acid supplementation (71 microg/kg) resulted in an improvement of both the baseline and the beta-ARs-mediated lipolysis. In controls, a lower beta2 and beta3-ARs protein expression of the adipose tissues was detected in +db/+db mice, compared to +m/+db mice. In both strains fed with folic acid (71 microg/kg), a reduction of beta2-AR protein expression was observed compared to the respective controls. In +db/+db mice, folic acid (5.7 and 71 microg/kg) consumption caused a dose-dependent increase of beta3-AR protein expression compared to controls. We demonstrate that lipolysis elicited by beta-AR (beta2- and beta3-ARs) agonists was blunted in +db/+db mice. Folic acid consumption has significant modulatory effects on beta-ARs protein expression and lipolysis.

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Pretty cool stuff.

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interesting