Pramipexole

[SallyAnne]

I've been reading the Anafit forums and there is a lot of discussion on Pramipexole. http://www.afboard.com/forum/womens-...-feedback.html

Not only is it being touted as a great prolactin antagonist - but women (and Ulter/Macro) are reporting fat loss and seriously elevated GH levels.

Anyone have experience with this drug? It's prescribed by doctors for Restless Leg Syndrome as well as depression...

[SallyAnne]

bump - no one has experience with this?

[heavyiron]

No experience with it but I have read similar reports. I am thinking of trying it myself.

[The Big Sexy]

I think a guy I know took this and he said his gyno lumps disappeared in about 5 days on it.

[SallyAnne]

I've been reading on bb forums that it helps with weight loss, but when I read regular reviews of the drug off Rx websites, people complain of weight gain...

[SallyAnne]

I think a guy I know took this and he said his gyno lumps disappeared in about 5 days on it.

I've read that, too - it reverses gyno. That would be amazing.

[The Big Sexy]

I've read that, too - it reverses gyno. That would be amazing.

Yeah - I was surprised to read that... but the guy I know is uber sensitive to test or anabolics of any kind... no matter what kind of anti-e's he takes he gets worse gyno... so, it was really a God-send for him.

[Carson]

My experience was nothing to write home about. I used it at .5mg ED for several weeks. There was no reduction in gyno, but it did put me to sleep, and a deep sleep at that. So there might have been a positive affect on HGH production.

[SallyAnne]

Ok - I wanted to update you guys on this drug. My fiance has been taking it and it has reversed about 50% of his gyno so far. He's also telling me he sleeps like a baby and his mood has greatly improved. He was so excited about the gyno thing - he was planning on going in for surgery to have it removed, but is going to wait to see how much the prami reverses.

He's taking 1mg Every night, or four .25 tablets. He tried splitting them up morning and night, but he says it makes him very tired if he takes any in the morning.

[heavyiron]

Ok - I wanted to update you guys on this drug. My fiance has been taking it and it has reversed about 50% of his gyno so far. He's also telling me he sleeps like a baby and his mood has greatly improved. He was so excited about the gyno thing - he was planning on going in for surgery to have it removed, but is going to wait to see how much the prami reverses.

He's taking 1mg Every night, or four .25 tablets. He tried splitting them up morning and night, but he says it makes him very tired if he takes any in the morning.

Any side effects at all?

[SallyAnne]

Any side effects at all?

He says no.

I looked at the side effects on the mayo clinic website and the most common are insomnia, headaches, runny nose, constipation, dry mouth, & weight loss.

[zubbeyboy]

There was a guy on promuscle message boards that almost died from it. Do your research.This shit is given to Parkinsons disease patients. Not nothing to be taken lightly. I dont have a good feeling about it and have researched it quite a bit. My advice? Stay away

[heavyiron]

He says no.

I looked at the side effects on the mayo clinic website and the most common are insomnia, headaches, runny nose, constipation, dry mouth, & weight loss.

Glad he has no sides.

Insomnia??? that's weird, I have heard numerous reports of it helping sleep. Maybe it is dose dependant.

[zubbeyboy]

Sleep from people i know was on it was not a problem. They had like crazy ass dreams. No like REAL crazy.

[heavyiron]

Lots of sex and gambling when you use it.

Frequency of new-onset pathologic compulsive gambling or hypersexuality after drug treatment of idiopathic Parkinson disease.

Bostwick JM, Hecksel KA, Stevens SR, Bower JH, Ahlskog JE.
Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN 55905, USA. [email protected]


Comment in:

• Mayo Clin Proc. 2009 Sep;84(9):846-7; author reply 847.

OBJECTIVE: To determine the frequency of new-onset compulsive gambling or hypersexuality among regional patients with Parkinson disease (PD), ascertaining the relationship of these behaviors to PD drug use. PATIENTS AND METHODS: We retrospectively reviewed the medical records of patients from 7 rural southeastern Minnesota counties who had at least 1 neurology appointment for PD between July 1, 2004, and June 30, 2006. The main outcome measure was compulsive gambling or hypersexuality developing after parkinsonism onset, including the temporal relationship to PD drug use. RESULTS: Of 267 patients with PD who met the study inclusion criteria, new-onset gambling or hypersexuality was documented in 7 (2.6%). All were among the 66 patients (10.6%) taking a dopamine agonist. Moreover, all 7 (18.4%) were among 38 patients taking therapeutic doses (defined as >/=2 mg of pramipexole or 6 mg of ropinirole daily). Behaviors were clearly pathologic and disabling in 5: 7.6% of all patients taking an agonist and 13.2% of those taking therapeutic doses. Of the 5 patients, 2 had extensive treatment for what was considered a primary psychiatric problem before the agonist connection was recognized. CONCLUSION: Among the study patients with PD, new-onset compulsive gambling or hypersexuality was documented in 7 (18.4%) of 38 patients taking therapeutic doses of dopamine agonists but was not found among untreated patients, those taking subtherapeutic agonist doses, or those taking carbidopa/levodopa alone. Behaviors abated with discontinuation of agonist therapy or dose reduction. Because this is a retrospective study, cases may have been missed, and hence this study may reflect an underestimation of the true frequency. Physicians who care for patients taking these drugs should recognize the drug's potential to induce pathologic syndromes that sometimes masquerade as primary psychiatric disease.

PMID: 19339647 [PubMed - indexed for MEDLINE]