Page 2 of 2 FirstFirst 12
Results 16 to 24 of 24

Thread: Pramipexole

  1. #16
    OLYMPIAN BEAST MODE's Avatar
    Join Date
    Feb 2009
    Location
    redefining brutality
    Posts
    16,884
    Rep Power
    176389

    Default

    OK I am confused after reading the dosing info...what is the recommended dosage if you're just starting on prami? I've seen start at .1ml and increase by .1 every few days until you need to back off. Is this accurate, and should it be taken daily? The info above confused me since it said to take e5 or e7.

  2. #17
    Chemistry Experiment heavyiron's Avatar
    Join Date
    Feb 2009
    Location
    anabolicmuscleforums.com
    Posts
    6,249
    Rep Power
    2147875

    Default

    Quote Originally Posted by richwa View Post
    OK I am confused after reading the dosing info...what is the recommended dosage if you're just starting on prami? I've seen start at .1ml and increase by .1 every few days until you need to back off. Is this accurate, and should it be taken daily? The info above confused me since it said to take e5 or e7.
    Start with 0.1mg three times per day and slowly increase dose. Most guys need around 0.5-1mg daily minimum.


    All posts are for entertainment and may contain fiction. Consult a doctor before using any medications. heavyiron does not advocate readers engage in any illegal activity.


  3. #18
    OLYMPIAN BEAST MODE's Avatar
    Join Date
    Feb 2009
    Location
    redefining brutality
    Posts
    16,884
    Rep Power
    176389

    Default

    Awesome...thanks bro!

  4. #19
    RedCon1 Aaron Singerman's Avatar
    Join Date
    Feb 2009
    Posts
    22,505
    Rep Power
    2148417

    Default

    What do you notice sexually when taking it?

  5. #20
    Chemistry Experiment heavyiron's Avatar
    Join Date
    Feb 2009
    Location
    anabolicmuscleforums.com
    Posts
    6,249
    Rep Power
    2147875

    Default

    Quote Originally Posted by Aaron Singerman View Post
    What do you notice sexually when taking it?
    Prami like most anti prolactin meds shortens the refractory period between male orgasms but if you already have low prolactin I am not sure you will notice that. Prami also increases sexual desire when taken by itself.


    All posts are for entertainment and may contain fiction. Consult a doctor before using any medications. heavyiron does not advocate readers engage in any illegal activity.


  6. #21
    Chemistry Experiment heavyiron's Avatar
    Join Date
    Feb 2009
    Location
    anabolicmuscleforums.com
    Posts
    6,249
    Rep Power
    2147875

    Default

    The chart below shows the effects of 0.5mg of Pramipexole on Prolactin, TSH and GH 2 hours after administration. Pramipexole had a profound facilitatory influence on the secretion of GH. The inhibitory effect of pramipexole on prolactin secretion seen here has been reported before.



    Br J Clin Pharmacol. 2007 Nov;64(5):591-602. Epub 2007 Jun 19.

    Comparison of pramipexole with and without domperidone co-administration on alertness, autonomic, and endocrine functions in healthy volunteers.

    Samuels ER, Hou RH, Langley RW, Szabadi E, Bradshaw CM.

    Source
    Psychopharmacology Section, University of Nottingham, Division of Psychiatry, Nottingham, UK.

    Abstract

    AIMS:

    To investigate the effects of the D2-receptor agonist pramipexole with and without the co-administration of the peripherally acting D2-receptor antagonist domperidone on measures of alertness, autonomic and endocrine function.

    METHODS:

    Sixteen male volunteers participated in four weekly sessions of pramipexole 0.5 mg, domperidone 40 mg, their combination, and placebo administered according to a balanced, double-blind design. Alertness (visual analogue scales (VAS), critical flicker fusion frequency, pupillographic sleepiness test), autonomic (pupil diameter, light and darkness reflexes, blood pressure, heart rate, salivation, temperature) and endocrine (prolactin, thyroid-stimulating hormone (TSH), growth hormone (GH)) functions were assessed. Data were analyzed with anova with multiple comparisons.

    RESULTS:

    The pre-post treatment changes in VAS alertness were reduced by pramipexole with and without domperidone (mean difference from placebo (95% confidence interval), mm): pramipexole -15.75 (-23.38, -8.13), combination -11.84 (-20.77, -2.91). Treatment condition significantly affected pupil diameter measured in different ways (resting pupil diameter (F(3,45) = 8.39, P < 0.001), initial diameter of the light reflex response (F(3,42) = 3.78, P < 0.05), and light (F(3,45) = 5.21, P < 0.005) and dark (F(3,45) = 3.36, P < 0.05) diameters of the darkness reflex response). Pramipexole without domperidone consistently increased pupil diameter on all measures (P < 0.05), whereas with domperidone only the increase in resting and dark diameters reached significance. Pramipexole reduced light reflex amplitude and increased latency, whereas the combination affected latency only. Concentrations of prolactin and TSH were increased by domperidone. Pramipexole reduced prolactin and increased GH concentrations.

    CONCLUSIONS:

    The attenuation of the central pupillary effects of pramipexole by domperidone indicates that domperidone had access to some central D2-receptors.

    PMID: 17578485 [PubMed - indexed for MEDLINE] PMCID: PMC2203276

    Attached Images Attached Images


    All posts are for entertainment and may contain fiction. Consult a doctor before using any medications. heavyiron does not advocate readers engage in any illegal activity.


  7. #22
    RX MEMBER nitrous's Avatar
    Join Date
    Aug 2009
    Location
    Abby, BC
    Posts
    1,174
    Rep Power
    15253

    Default

    Prami lowered prolactin (expected) and actually increased plasma concentrations of GH that's interesting

  8. #23
    RX MEMBER
    Join Date
    Nov 2010
    Location
    Brazil
    Posts
    39
    Rep Power
    0

    Default

    Quote Originally Posted by lartinos View Post
    Sounds similar to selegiline
    I use both , and i feel prami like a powerful and fast acting selegiline.
    Prami is a very sensible dose related drug, once you go high the sides are wacky.

  9. #24
    RX MEMBER
    Join Date
    Nov 2010
    Location
    Brazil
    Posts
    39
    Rep Power
    0

    Default

    Quote Originally Posted by Aaron Singerman View Post
    What do you notice sexually when taking it?
    Not only this refractary period reduction, but also the genital sensitive feeling much better ( dopaminergic transmissioan enhanced ) , harder and much easier erections .

Page 2 of 2 FirstFirst 12

Posting Permissions

  • You may not post new threads
  • You may not post replies
  • You may not post attachments
  • You may not edit your posts
  •  

X vBulletin 4.2.3 Debug Information

  • Page Generation 0.13724 seconds
  • Memory Usage 7,095KB
  • Queries Executed 26 (?)
More Information
Template Usage (44):
  • (1)SHOWTHREAD
  • (1)ad_footer_end
  • (1)ad_footer_start
  • (1)ad_global_above_footer
  • (1)ad_global_below_navbar
  • (1)ad_global_header1
  • (1)ad_global_header2
  • (1)ad_navbar_below
  • (1)ad_showthread_firstpost_sig
  • (1)ad_showthread_firstpost_start
  • (1)ad_thread_first_post_content
  • (1)ad_thread_last_post_content
  • (4)bbcode_quote
  • (4)block_html
  • (1)block_threads
  • (1)facebook_footer
  • (1)facebook_header
  • (1)facebook_likebutton
  • (1)facebook_opengraph
  • (1)footer
  • (1)forumjump
  • (1)forumrules
  • (1)gobutton
  • (1)header
  • (1)headinclude
  • (1)headinclude_bottom
  • (9)memberaction_dropdown
  • (1)navbar
  • (4)navbar_link
  • (1)navbar_noticebit
  • (1)navbar_tabs
  • (3)option
  • (1)pagenav
  • (1)pagenav_curpage
  • (1)pagenav_pagelink
  • (1)postbit_attachment
  • (9)postbit_legacy
  • (9)postbit_onlinestatus
  • (9)postbit_wrapper
  • (3)showthread_bookmarksite
  • (1)sidebarext_temp
  • (1)spacer_close
  • (1)spacer_open
  • (1)tagbit_wrapper 

Phrase Groups Available (6):
  • global
  • inlinemod
  • postbit
  • posting
  • reputationlevel
  • showthread
Included Files (37):
  • ./showthread.php
  • ./global.php
  • ./includes/class_bootstrap.php
  • ./includes/init.php
  • ./includes/class_core.php
  • ./includes/config.php
  • ./includes/functions.php
  • ./includes/functions_navigation.php
  • ./includes/class_friendly_url.php
  • ./includes/class_hook.php
  • ./includes/class_bootstrap_framework.php
  • ./vb/vb.php
  • ./vb/phrase.php
  • ./includes/class_facebook.php
  • ./includes/facebook/facebook.php
  • ./includes/facebook/base_facebook.php
  • ./includes/functions_facebook.php
  • ./includes/functions_bigthree.php
  • ./includes/class_postbit.php
  • ./includes/class_bbcode.php
  • ./includes/functions_reputation.php
  • ./includes/class_block.php
  • ./includes/block/html.php
  • ./vb/context.php
  • ./vb/cache.php
  • ./vb/cache/db.php
  • ./vb/cache/observer/db.php
  • ./vb/cache/observer.php
  • ./includes/functions_notice.php
  • ./includes/block/threads.php
  • ./packages/vbattach/attach.php
  • ./vb/types.php
  • ./packages/skimlinks/hooks/postbit_display_complete.php
  • ./packages/skimlinks/hooks/showthread_complete.php
  • ./mobiquo/smartbanner.php
  • ./mobiquo/include/classTTConnection.php
  • ./mobiquo/smartbanner/head.inc.php 

Hooks Called (79):
  • init_startup
  • database_pre_fetch_array
  • database_post_fetch_array
  • friendlyurl_resolve_class
  • global_bootstrap_init_start
  • global_bootstrap_init_complete
  • cache_permissions
  • fetch_threadinfo_query
  • fetch_threadinfo
  • fetch_foruminfo
  • load_show_variables
  • load_forum_show_variables
  • global_state_check
  • global_bootstrap_complete
  • global_start
  • style_fetch
  • global_setup_complete
  • showthread_start
  • cache_templates
  • cache_templates_process
  • template_register_var
  • template_render_output
  • fetch_template_start
  • fetch_template_complete
  • friendlyurl_clean_fragment
  • friendlyurl_geturl
  • fb_canonical_url
  • fb_opengraph_array
  • parse_templates
  • fetch_musername
  • notices_check_start
  • notices_noticebit
  • process_templates_complete
  • showthread_getinfo
  • strip_bbcode
  • forumjump
  • friendlyurl_redirect_canonical
  • showthread_post_start
  • showthread_query_postids
  • fetch_postattach_query
  • showthread_query
  • bbcode_fetch_tags
  • bbcode_create
  • showthread_postbit_create
  • postbit_factory
  • postbit_display_start
  • reputation_power
  • reputation_image
  • postbit_imicons
  • bbcode_parse_start
  • bbcode_parse_complete_precache
  • bbcode_parse_complete
  • postbit_display_complete
  • memberaction_dropdown
  • bbcode_img_match
  • postbit_attachment
  • pagenav_page
  • pagenav_complete
  • tag_fetchbit_complete
  • forumrules
  • showthread_bookmarkbit
  • navbits
  • navbits_complete
  • build_navigation_data
  • build_navigation_array
  • check_navigation_permission
  • process_navigation_links_start
  • process_navigation_links_complete
  • set_navigation_menu_element
  • build_navigation_menudata
  • build_navigation_listdata
  • build_navigation_list
  • set_navigation_tab_main
  • set_navigation_tab_fallback
  • navigation_tab_complete
  • fb_publish_checkbox
  • fb_like_button
  • showthread_complete
  • page_templates