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  1. #1
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    Default Turinabol~4-chlorodehydromethyltestosterone

    Oral Turinabol (4-chlorodehydromethyltestosterone)


    Androgenic no data available
    Anabolic >100
    Standard Methyltestosterone (oraI)
    Chemical Name 4-chloro-17a-methyl-17bhydroxyandrosta-1,4-dien-3-one
    Estrogenic Activity none Progestational Activity no data available (low)

    Description:

    Chlorodehydromethyltestosterone is a potent derivative of Dianabol. This oral steroid is structurally a cross between methandrostenolone and clostebol (4-chlorotestosterone), having the same base structure as Dianabol with the added 4-chloro alteration of clostebol. This alteration makes chlorodehydromethyltestosterone a milder cousin of Dianabol, the new steroid displaying no estrogenic and a much less androgenic activity in comparison to its more famous counterpart. The anabolic activity of chlorodehydromethyltestosterone is somewhat lower than that of Dianabol as well, but it does maintain a much more favorable balance of anabolic to androgenic effect. This means that at any given level of muscle-building activity, chlorodehydromethyltestosterone will be less likely to produce androgenic side effects.

    History:
    Chlorodehydromethyltestosterone was first described in 1962. Jenapharm (Jena, Germany) soon after released the drug for sale in the East German prescription drug market, under the brand name Oral Turinabol. The drug was favored by clinicians for its highly anabolic and low anabolic nature, lending .itself to use in not only adult males, but women and children as well. The product was manufactured in two strengths, containing 1mg and 5 mg of drug per tablet, so that a lower-dosed version was available for the more sensitive populations. Chlorodehydromethyltestosterone was applied for a number of medical uses; mainly those focusing on the building or preservation of lean muscle tissue and bone mass.
    Oral Turinabol became a steroid of infamy during the 1990's, when it was revealed that chlorodehydromethyltestosterone had been one of the closely held secrets inside the "East German Doping Machine." This is referring to the state-sponsored doping program, called "State Plan Research Theme 14.25," that operated in East Germany between 1974 and 1989. It was an aggressive anabolic steroid administration program, designed with one goal in mind: cheating the Olympic drug test. In many cases, the Olympic athletes, both male and female, were unwitting participants, simply told by their trainers and coaches that they were being given "vitamins." Many of these blue vitamins turned out to be Oral Turinabol, a potent and undetectable (at the time) anabolic steroid. As many as 10,000 athletes were given anabolic steroids during the time the program was active, many of them taking Oral Turinabol. For a more in-depth look at this dramatic historic event, including the trials of several former East German officials for their participation, I recommend you look at the book"Faust's Gold: Inside the East German Doping Machine" by Steven Ungerleider.
    In spite of an arguably favorable profile of activity and safety record, Jenapharm discontinued Oral Turinabol in 1994. This was at a time when a great deal of negative attention was being given to sports doping, lending credibility to the speculation that this decision was one based on public relations, and not necessarily finances or health concerns over the drug. Regardless,Jenapharm was acquired by Schering AG (Germany) in 1996, a company with no interest in reliving the controversies of the past (Schering had already discontinued many of its controversial anabolic steroid products as well). Before or since, no other brand 0f chlorodehydromethyltestosterone has existed as a prescription drug product. Today, this agent is still available, but is only produced by a small number of underground manufacturers and export-only suppliers.

    How Supplied:
    Chlorodehydromethyltestosterone is not available as a prescription drug product. When manufactured, it was found in 1mg and 5 mg tablets, sold in Germany/German Democratic Republic.

    Structural Characteristics:
    Chlorodehydromethyltestosterone is a modified form of testosterone. It differs by: 1) the addition of a methyl group at carbon 17-alpha, which helps protect the hormone during oral administration, 2) the introduction of a double bond between carbons 1 and 2 (l-ene), which shifts the anabolic to androgenic ratio in favor of the former, and 3) the attachment of a chloro group at carbon 4, which inhibits steroid aromatization and reduces relative androgenicity.

    Administration (Men):
    A common clinical dose of chlorodehydromethyltestosterone is estimated to be 5 mg per day; actual prescribing guidelines are unavailable. In the athletic arena, an effective oral daily dosage falls in the range of 15-40 mg, taken in cycles lasting no more than 6-8 weeks to minimize hepatotoxicity. This level is sufficient for measurable increases in lean muscle mass and strength. This agent is most often applied as a precontest or cutting steroid for bodybuilding purposes, and is not viewed as an ideal bulking agent due to its lack of estrogenicity. Athletes in sports where speed tends to be a primary focus also find strong favor in chlorodehydromethyltestosterone, obtaining a strong anabolic benefit without having to carry around any extra water or fat weight.
    Administration (Women):
    A common clinical dose of chlorodehydromethyltestosterone is estimated to be 1
    2.5 mg per day; actual prescribing guidelines are unavailable. In the athletic arena, women would commonly take a single 5 mg tablet per day, taken in cycles lasting no more than 4-6 weeks to minimize hepatotoxicity. Virilizing effects are unlikely at this level of use. Much higher doses were often used with female athletes in the former GDR doping program, but often to detriment of strong virilizing side effects.


    Reference:
    Llewellyn’s W. (2009). Anabolics (9th ed), Oral Turinabol 4-chlorodehydromethyltestosterone(pp. 339-341): Jupiter, FL: Molecular Nutrition

  2. #2
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    Oral-Turinabol

    Oral Turinabol was first developed by scientists in East Germany for their Olympic and national-level athletes to use. This, plus the eventual removal of it from the market caused OT to become a very "sexy" drug for athletes to try and obtain. The East Germans studied this drug pretty extensively for many years and some of the success of this now defunct country was attributed to this drug, which made it´s first appearance to athletes in East Germany as little blue "Vitamins" their coaches gave to them. This drug has been discontinued by all of the major pharmaceutical houses, and is only found through certain underground labs. Even though some UnderGround Labs have access to this item, and it appears on their price-lists, it´s still rare enough. I believe it was first produced in the last half decade by a certain cat in Thailand. It´s my speculation that it´s on the cusp of either becoming very popular, to the point where every Underground Lab will start carrying their own version of it, or it will disappear again and only be carried by a select few, if any, suppliers.

    The easiest way to explain this drug is that it is a derivative of Dianabol. Though it is a derivative of our old friend Diana, it´s still quite different...remember, Equipoise is estrified Dianabol, and really has nothing in common with it, in terms of real-world-effects. Let´s examine OT in relation to D-bol for now, though. The first similarity between the two is that they have both been 17-alpha-alkylated (a carbon atom was added at the 17th position) to survive the first pass through the liver. This, of course, increases hepatoxicity (liver toxicity). OT has a much lower level of androgenic activity compared to dianabol, but a better balance/ratio of anabolic and androgenic effects. It has a rating of a 0 (according to the Vida reference) for androgenic properties and a 53 for anabolic properties based on a score of 100 each for testosterone. This promotes more of a "hard" look, of what competition bodybuilders often call "quality" muscle. You do not get the same "puffy" look as you would on d-bol, and many people have thus compared the results they´ve gotten from OT to Anavar. Actually, though, this stuff is simply dianabol with a 4-chloro alteration, the same alteration found in Clostebol.

    Due to this 4-chloro substitution in the A-Ring of its Steran Nucleus, this drug cannot be aromatized (3). This is, as you know, quite beneficial and is one of the reasons Oral Turinabol has been called a "gentle d-bol." You will probably not get any typical estrogenic side effects like water retention, acne, gyno, etc, at any dose of this drug. A couple of studies I read examining male athletes over a period of six weeks were given 10 mg OT/day did not show any indications of health-threatening effects. It has been recommended that men should take between 20-40mg every day and women a 5mg every day, and I generally think that it is not very strong (as compared to many other orals) and wouldn´t drop below the 40mg mark if I were to use it personally. It may perhaps be used in low(er) doses if it is simply being used for it´s ability to reduce SHBG´s binding (1) to other steroids. In this respect, it may have synergy with other drugs, since it has the ability to reduce SHBG and thus free up more testosterone for use in your body.

    The only negative thing I have heard about this drug is that in high doses (10+mg) virilization has been seen in women(14) and there has been at least one case of testicular tumors, and one case of a guy who suffered adverse effects from 5 years of high-dose use of OT (2)(4). It should be noted that the former East Germans did many experiments with this drug in high doses though, and found it to be a very suitable compound for their athletes. Many of the women suffered virilization at higher doses, though. During the 68-72 Olympic cycles, the East German Sports OT program made its biggest impact. It was around this time, that the East German weightlifters were taking over 10g/year of OT, and their leading male sprinter was taking under 730mgs/year of OT (14). I think this tells me that for real weight gains, and huge gains in the weight room, you´re going to need bank-breaking dosages of this stuff. On the bright side, if you are an athlete looking to get faster, a little bit of OT will get you there pretty easily, and with minimal (if any) side effects). I think that it´s inability to cause negative side effects, and it´s ability to produce a favorable increase in lean body mass and thus a favorable increase in strength/speed and an athlete´s strength:bodyweight ratio is what turned the East German coaches and scientists on. It must be noted that, at the time, this stuff was mostly undetectable, and that was certainly a sought after trait by the East Germans, who were looking to circumvent the drug testing procedures of the IOC. Now, of course, OT is detectable, as once it´s administered to man, three major metabolites are formed: 6 beta-hydroxy-turinabol, 6 beta, 12-dihydroxy-turinabol, and 6 beta, 16-dihydroxy-turinabol (5)(8)(9).All of those metabolites are now detectable by drug screeners. In much smaller quantities at least another three metabolites are excreted, one of which could be identified as 17 epi-turinabol (5), and is easily detected by modern drug tests... No measurable amounts of OT itself is detected in any of the urine samples investigated in sports doping procedures, but the presence of the metabolites is enough to warrant a positive result, and a failed test. Keeping all of this in mind, it is still important to note that the rate of metabolism and urinary excretion or Oral Turinabol is reasonably fast (5), even though it is technically eliminated biphastically (in two stages) by the body, with a terminal 16hr ½ life (1). I think that the sports-doping-party-poopers (The NCAA and IOC) OT is notorious for increasing the time it will take for your blood to clot because it has spontaneous fibrinolytic properties. "Fibrinolytic effects" means that the destruction of fibrin (an insoluble fibrous protein produced in the liver from the soluble protein) is happening in your body. Fibrinogen is important during the blood clotting process, as it is a soluble protein in the blood that is converted to insoluble fibrin by the action of the enzyme thrombin in response to tissue damage. (6)(7) Thus, you will bleed for longer than usual when on this stuff, combine that with the fact that steroids raise your hematocrit and you´ll be spending your entire morning trying to stop the bleeding if you cut yourself shaving. Well, that´s probably an exaggeration, but not by much.

    Oral Turinabol Olympic Cycle

    I´ve already told you that this stuff is a potent lean tissue builder, and good for cutting. But that´s mostly of interest for bodybuilders. Now, with regards to athletics, what kind of results can we expect? Well, I was digging through the old East German literature, and found that they reported that their world class strength athletes were making some pretty remarkable improvements on OT, over a 4 year Olympic training period: Male Shot-putters were adding 2.5-4m to their shot throws, 10-12m on their Discus throw, and 6-10m to their Hammer throws. Female athletes gained even more. Lets take a look at a chart representing the improvements made by one particular female strength athlete (*she held the World Record for the shot put, at the time of her beginning OT administration), over a the period of July 18th 1968 through October 13th 1972. During the time she was taking OT, she improved her throw from under 18m to over 20m (yes, this is a 2m+ improvement, to a world record holding throw, in one Olympic Cycle). She was taking roughly 5-15mgs/day of OT in the beginning, but worked up to 35mgs/day before she was done with her Olympic cycle. Her throws even while "off" OT even improved a bit, leading to speculation that there are a lot of permanent gains to be had with OT. Anyway, here are the charts representing her intake of OT, as well as her improvements over her 4 year over her 4 year Olympic training regimen:
    Effects of an androgenic-anabolic steroid, Oral-Turinabol, on the shot-put performance (in meters, y-axis) of a female athlete (code identification 1/68 in a, 1/69 in b, and 1/72 in c) directly photographed from the secret scientific report of Bauersfeld et al. (13), as one of the numerous examples documented, chosen here because of its historic importance as the first documented case of androgenic doping of a woman (for a detailed account, see ref. (11)). (a) 1968. The rectangle from July 28 to October 13 shows the period of drug administration, and the numbers above each date show the number of tablets taken per week (here, 14, or 10 mg per day). The curve presents the results of the specific competitions, showing the increase of strength and performance in a fully trained woman. At the time of the first drug application in 1968, the athlete had been well trained for almost 14 years. Under the influence of the drug, however, she gained unprecedented muscle strength and improved her records dramatically within a few weeks. (b) 1969. The steroid was given in three cycles and at various dosages, from 7 to 21 tablets per week (i.e., 5 15 mg daily). Without the drug, she could not reach 18 m but when taking the drug, she improved her world record once more, to 20.10 m. (c) 1972. She took even more of the androgenic hormone, with daily dosages of up to 7 tablets per day (35 mg), in four cycles, for a total androgenic load of 1450 mg for the year. This led to her top performances in the winter indoor season (left curve) as well as in the summer (right curve) and another personal best (20.22 m). Note the much lower performance at times off the drug or after only short periods of androgenization. Also, after 4 years of systematic androgenization, her basic strength level even when not taking the drug had also increased by ~1 m, indicative of a residual effect. (14)

    Did all of this work for anyone else? Well, as I told you, virtually everyone who was involved with the East German Olympic Training program was on steroids of some kind, but OT was by and far away the most popular. They had access to some pretty weird stuff, too& intranasal testosterone, etc&

    So... back to OT... it is notable from my readings on this compound that women saw much more positive effects from OT than men (this is true of all steroids, though). Women also saw more side effects, and generally found the side effects to be more severe and unbearable than their male counterparts. Unfortunately, they also (sometimes) tended to use higher dosages than the men did; often up to 2x as high. Lets take a look at their typical yearly doses:

    Some documented dosages of androgenic-anabolic steroid (Oral-Turinabol)1 taken by female GDR medal winners (track and field) in Olympic Games, World Championships, and European Championships.2

    (Annual dosage of OT in mgs followed by Events)
    3680 Shot-put
    3190 Discus
    2900 Shot-put
    2615 Shot-put
    2590 Shot-put
    1670 Sprint
    1560 Hurdles
    1480 Hurdles
    1474 Sprint
    1460 Sprint
    1450 Shot-put
    1405 Sprint
    1380 Heptathlon
    1375 Sprint
    1340 Heptathlon
    1255 Discus
    1230 Heptathlon
    1230 Hurdles
    1185 Javelin

    1. Additional injections of testosterone esters have not been considered here.
    2. Data taken from ref. (14), which gives names and details. At least 12 of the drug-receiving competitors listed in this table set world records.
    In keeping with Journal policy regarding confidentiality of patients and subjects, the names of subjects have been omitted.
    Shocked? Don´t be. This was during the cold war, and victory in the Olympics was seen as a victory for a certain way of life and a certain ideology; defeat was unthinkable and unacceptable.
    Is the recent reappearance of Oral-Turinabol on the black market going to change athletics or bodybuilding dramatically? No... I doubt it... a combination of price ($1/10mgs average) and availability may cause this stuff to remain an understated tool at our disposal. It is, however, a viable tool in a lean mass cycle, cutting cycle, or any athlete´s drug intake routine.
    As a final reference, I´ll give you an example (direct from the East German State Doping Program´s reports) on how they used OT throughout the year, and with various other drugs (like Test Prop, for example):
    (Anabolic and special preparation for the top competition of the year during the immediate preparation period in the Olympic cycle 1980/84, using the example of some selected long jumpers (W) and a high jumper (H) in combination with the results of competitions during this time)
    Example (from hundreds of evaluations) showing typical administration patterns of orally taken synthetic anabolic-androgenic steroids (Oral-Turinabol, periods of application denoted by rectangles) and injections of testosterone esters [arrows, 10 mg of testosterone propionate (TP); triangles, 25 mg of TP; circles, 100 mg of testosterone enanthate plus 1500 IU of hCG], here given to high (H) and long (W, Weitsprung) jumpers during the last 10 weeks before a major international competition in 1981 1984 [immediate preparation period (UWV), in weeks, is indicated on the x-axis; WS, competition series preceding the UWV; the competition results (in meters) are shown immediately above the specific drug application symbols].(14)

    Oral Turinabol Profile

    (4-chlorodehydromethyltestosterone)
    [4-chloro-17b-hydroxy-17a-methyl-androst-1,4-dien-3-one]
    Molecular Weight:334.8854
    Formula:C20H27O2Cl
    Manufacturer: Underground Labs only
    Effective Dose (Men): 10-40mgs/day
    Effective Dose (Women): 5-15mgs/day
    Active life: 16 hours
    Detection Time: 6 weeks
    Anabolic/ Androgenic ratio: >100:>0
    References:

    1. [The pharmacokinetics of Oral-Turinabol in humans] Pharmazie. 1991 Sep;46(9):650-4. German.
    2. Department of Urology, Universitaetsklinikum "Carl Gustav Carus," Technical University of Dresden,Dresden, Germany
    3. Influence of 1-double bond and 11 beta-hydroxy group on stereospecific microbial reductions of 4-en-3-oxo-steroids. J Steroid Biochem. 1986 Oct;25(4):561-6.
    4. Intratesticular leiomyosarcoma in a young man after high dose doping with Oral-Turinabol: a case report. Cancer. 1999 Oct 15;86(8):1571-5.
    5. GC and capillary column GC/MS determination of synthetic anabolic steroids. II. 4-chloro-methandienone (oral turinabol) and its metabolites. J Chromatogr Sci. 1983 Sep;21(9):405-10.
    6. [Activation of the fibrinolytic system with dehydrochlormethyltestosterone] Folia Haematol Int Mag Klin Morphol Blutforsch. 1984;111(4):556-62. German.
    7. [Modification of hypofibrinolytic states by dehydrochlormethyltestosterone] Folia Haematol Int Mag Klin Morphol Blutforsch. 1984;111(4):563-6. German.
    8. [Application of microbial enzymes in studies of steroid metabolism (author´s transl)] Acta Microbiol Acad Sci Hung. 1975;22(4):397-402. Review. German.
    9. [Application of microbial enzymes in studies of steroid metabolism (author´s transl)] Acta Microbiol Acad Sci Hung. 1975;22(4):397-402. Review. German.
    10. [ON THE PHARMACOLOGY OF "ORAL TURINABOL".] Dtsch Gesundheitsw. 1965 Apr 15;20:690-1. German. No abstract available.
    11. Berendonk B. Doping. Von der Forschung zum Betrug. Reinbek bei Hamburg: Rowohlt Taschenbuchverlag. 1992:448pp
    12. [4-CHLORO-DELTA-1-METHYLTESTOSTERONE (ORAL TURINABOL), A NEW EFFECTIVE ORAL ANABOLIC STEROID.] Dtsch Gesundheitsw. 1965 Apr 15;20:670-4. German. No abstract available.
    13. Bauersfeld K-H. Olek J. Meibner H. Hannemann D. Spenke J. Analyse des Einsatzes u. M. in den leichtathletischen Wurf/Stob-disziplinen und Versuch trainingsmethodischer Abteilungen und Verallgemeinerungen. Science Center of the DVfl 1973:41pp.
    14. Clinical Chemistry 43:7. 1262-1279 (1997)
    steroid.com


    All posts are for entertainment and may contain fiction. Consult a doctor before using any medications. heavyiron does not advocate readers engage in any illegal activity.


  3. #3
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    Hormonal doping and androgenization of athletes: a secret program of the German Democratic Republic government

    Werner W. Franke1,a and Brigitte Berendonk2


    1 Division of Cell Biology/0110, German Cancer Research Center, Im Neuenheimer Feld 280, D-69120 Heidelberg, Germany.

    2 Hölderlin High School, Heidelberg, Germany.
    a Author for correspondence. Fax 49-6221-423404.

    Abstract Several classified documents saved after the collapse of the German Democratic Republic (GDR) in 1990 describe the promotion by the government of the use of drugs, notably androgenic steroids, in high-performance sports (doping). Top-secret doctoral theses, scientific reports, progress reports of grants, proceedings from symposia of experts, and reports of physicians and scientists who served as unofficial collaborators for the Ministry for State Security ("Stasi") reveal that from 1966 on, hundreds of physicians and scientists, including top-ranking professors, performed doping research and administered prescription drugs as well as unapproved experimental drug preparations. Several thousand athletes were treated with androgens every year, including minors of each sex. Special emphasis was placed on administering androgens to women and adolescent girls because this practice proved to be particularly effective for sports performance. Damaging side effects were recorded, some of which required surgical or medical intervention. In addition, several prominent scientists and sports physicians of the GDR contributed to the development of methods of drug administration that would evade detection by international doping controls.

    http://www.clinchem.org/cgi/content/full/43/7/1262


    All posts are for entertainment and may contain fiction. Consult a doctor before using any medications. heavyiron does not advocate readers engage in any illegal activity.


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    i want to get some?

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    forever 21 gift cards H36oBysz2880wx7s1794596v

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