oral steroids.... with meals or empty stomach?

[Chadstallion]

winstrol; on empty stomach or with food?

[bad rad]

Personally I do with food since stomach upset can be a side effect.

[NPCKnight]

Just do whatever but take them with GF juice.

[Bigphil]

Just do whatever but take them with GF juice.

grape fruit juice i was told this enhances effects of anything you take i am very sceptical is this why you recomend it? any science behind it

[NPCKnight]

I guess you dont have the internet to search for it yourself . LOL ofcourse there is science behind it.

Grapefruit juice interferes with gut enzymes that influence the transport of drugs into the body, which makes the drugs more concentrated and potentially dangerous. It can increase blood concentrations of some drugs by 1.5 to 15 times above normal for a particular dose...

from Nutrition Today, 43: 19-28, 2008

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It doens't interfere with absorbtion, it works on the the enzyme that is responsible for metabolism of many oral drugs - specificaly cytochrome P450 - iso-enzyme 3A4.

3A4 wil preferentially metabolize the grapfruit juice and therefore be 'tied up' and unavailable to metabolize other drugs. This won't ultimatley prevent the drugs metabolism, just slow it.

Most drugs are dosed at intervals which are based on the typical metabolism in the average person. Adjustments are often required in pateints that are renally or hepaticaly impared. Grapefruit juice has the potential to change the rate of metabolism of a drug, and when dosed at the normal interval, concentrations can build to toxic levels.

["Rodz"]

I guess you dont have the internet to search for it yourself . LOL ofcourse there is science behind it.

Grapefruit juice interferes with gut enzymes that influence the transport of drugs into the body, which makes the drugs more concentrated and potentially dangerous. It can increase blood concentrations of some drugs by 1.5 to 15 times above normal for a particular dose...

from Nutrition Today, 43: 19-28, 2008

-------------

It doens't interfere with absorbtion, it works on the the enzyme that is responsible for metabolism of many oral drugs - specificaly cytochrome P450 - iso-enzyme 3A4.

3A4 wil preferentially metabolize the grapfruit juice and therefore be 'tied up' and unavailable to metabolize other drugs. This won't ultimatley prevent the drugs metabolism, just slow it.

Most drugs are dosed at intervals which are based on the typical metabolism in the average person. Adjustments are often required in pateints that are renally or hepaticaly impared. Grapefruit juice has the potential to change the rate of metabolism of a drug, and when dosed at the normal interval, concentrations can build to toxic levels.

Pharmacies actually have little stickers that say "do not consume grapefruit juice" for some scripts

[IzlamikPork]

winstrol; on empty stomach or with food?

I do Winnie on an empty stomach, just before heading out the door to the gym. Hits like a freight train that way.

[Chadstallion]

Pharmacies actually have little stickers that say "do not consume grapefruit juice" for some scripts

my lipator has that; don't know what it will do but, hey, i'll follow the little sticker's advice!

[NPCKnight]

Dont ever do it with drugs like lipitor. NEVER.

[-BLP-]

chew steroid , better absorption , stomach doesnt need dissolve binder , micronized home made with teeth grrrrrrrrrrrr

[natron]

my lipator has that; don't know what it will do but, hey, i'll follow the little sticker's advice!

Basically makes the drug more effective, and sometimes thats not a good thing ie cholesterol lowering drugs, blood thinners, duiretics etc

[natron]

chew steroid , better absorption , stomach doesnt need dissolve binder , micronized home made with teeth grrrrrrrrrrrr

YES! Always listen to BLP! lol

["Rodz"]

Dont ever do it with drugs like lipitor. NEVER.

truth. i hear its on levitra and cialis as well.......................lol

[Bigphil]

nice