'Fountain of youth' steroids may protect against heart disease

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'Fountain of youth' steroids may protect against heart disease

Steroids sold as health supplements can switch on a natural defence mechanism against heart disease, according to University of Leeds researchers.

The University of Leeds biologists have identified a previously-unknown ion channel in human blood vessels that can limit the production of inflammatory cytokines – proteins that drive the early stages of heart disease.

After analyses, boffins found that this protective effect can be triggered by pregnenolone sulphate - a molecule that is part of a family of ‘fountain-of-youth’ steroids. These steroids are so-called because of their apparent ability to improve energy, vision and memory.

Collaborative studies with surgeons at Leeds General infirmary have shown that this defence mechanism can be switched on in diseased blood vessels as well as in healthy vessels.

So-called ‘fountain of youth’ steroids are made naturally in the body, but levels decline rapidly with age.

This has led to a market in synthetically made steroids that are promoted for their health benefits, such as pregnenolone and DHEA. Pregnenolone sulphate is in the same family of steroids but it is not sold as a health supplement.

"The effect that we have seen is really quite exciting and also unexpected," said Professor David Beech, who led the study. "However, we are absolutely not endorsing any claims made by manufacturers of any health supplements. Evidence from human trials is needed first."

A chemical profiling study indicated that the protective effect was not as strong when cholesterol was present too. This suggests that the expected benefits of ‘fountain of youth’ steroids will be much greater if they are used in combination with cholesterol-lowering drugs and/or other healthy lifestyle strategies such as diet and exercise.

"These ‘fountain of youth’ steroids are relatively cheap to make and some of them are already available as commercial products. So if we can show that this effect works in people as well as in lab-based studies, then it could be a cost-effective approach to addressing cardiovascular health problems that are becoming epidemic in our society and world-wide," Professor Beech added.

The study finding has been published in Circulation Research.
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[s2h]

kool...i just gave my 13 year old 2 cc's of tren....better see some homeruns at todays tourny......

[Big Barry]

They should tally up all these studies..... "Steroids good for heart" VS "Steroids bad for heart"

Let's see which school of thought wins each week, lol.

[TPT]

pregnenolone sulfate has promise marketed as a focus/memory supplement.

it has very little if any anabolic or androgenic effects.

[Barrett]

i like to drink urine.

[s1cfuc]

i think steroids in moderation not abuse could be good for the heart. just like anything thought people abuse it and have problems because of it.

[Big Barry]

i like to drink urine.

Most people drink urine for the "Great" taste... unfortunately there's very few nutrients in an ice-cool and refreshing glass of piss!!

[SweetCapri]

Most people drink urine for the "Great" taste... unfortunately there's very few nutrients in an ice-cool and refreshing glass of piss!!

I just threw up in my mouth a little bit. This is gross.

[SweetCapri]

pregnenolone sulfate has promise marketed as a focus/memory supplement.

it has very little if any anabolic or androgenic effects.

As soon as I read Dave's post I was hoping you'd already translated the study findings with a reply. You never let me down!

[GREENMACHINE23]

They should tally up all these studies..... "Steroids good for heart" VS "Steroids bad for heart"

Let's see which school of thought wins each week, lol.

My thoughts exactly.