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03-22-2009, 09:31 AM #1
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Clenbuterol is well-tolerated in cronic heart-failure patients.
The following is a clinical study on administration of clenbuterol to chronic heart failure patients versus placebo controls. Geuss what? Its well-tolerated by both controls and heart-failure patients....
I will have a look at the specifics of the study at work, such as dose, measurements, etc..
1: J Heart Lung Transplant. 2008 Apr;27(4):457-61. Links
Comment in: J Heart Lung Transplant. 2008 Aug;27(8):934-5. Clenbuterol increases lean muscle mass but not endurance in patients with chronic heart failure.
Kamalakkannan G, Petrilli CM, George I, LaManca J, McLaughlin BT, Shane E, Mancini DM, Maybaum S.
Division of Cardiology, Department of Medicine, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, New York, USA.
Clenbuterol, a beta(2)-agonist with potent anabolic properties, has been shown to improve skeletal muscle function in healthy subjects, and in high doses, promotes cardiac recovery in patients with left ventricular assist devices. In a small, randomized controlled study, we investigated the effect of clenbuterol on skeletal muscle function, cardiac function, and exercise capacity in patients with chronic heart failure. Clenbuterol was well tolerated and led to a significant increase in both lean mass and the lean/fat ratio. Maximal strength increased significantly with both clenbuterol (27%) and placebo (14%); however, endurance and exercise duration decreased after clenbuterol. Prior data support combining exercise training with clenbuterol to maximize performance, and on-going studies will evaluate this approach.
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03-22-2009, 09:34 AM #2
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notice that the study measures effects on heart function with clenbuterol.
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03-22-2009, 11:18 AM #3
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interesting. i can't pull up the full text for the specs but, curious to read of the possible indications for clenbuterol for cardiac patients. hard to imagine post cardiac sugery patients being prescribed clen. however, the outcomes measures appear facinating. well, i'll be waiting for details.
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03-22-2009, 12:26 PM #4
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Yeah. it seems strange, but my only point with this study is that clenbuterol administered in clinical studies at normal doses and even in unhealth patients does not appear to cause problems with heart function.
This is, of course, does not prove that under all conditions and dosages clenbuterol is safe, nor for all administration protocols and lengths.
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03-22-2009, 06:49 PM #5
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can't tell but, low dosages and short lenghts were probably used. especially considering patients with chronic heart failure usually have a history of ischaemic heart disease and hypertension. and we already know of the typical cns and cardiac sides of clen including nausea, sweating, hypertension, etc. however, your iteration of the possible "safetyness" of clen was well taken since subjects were not even healthy.
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03-23-2009, 05:32 PM #6
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40 micrograms first week, thereafter 80 micrograms per day for 12 weeks straight.
two clen patients had asymptomatic tachycardia, one placebo had intermittent ventricular tachycardia.
No arrythmias. No heart problems. decreased mean arterial pressure.
All in all it was deamed safe and effective for skeletal muscle growth.
By the way, there are litterally tens of trials of clen for various purposes, from asthma to wasting to heart failure treated with an implant and clenbuterol. None reported heart problems in the abstract anyway.
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03-24-2009, 03:14 AM #7
Does clen raise cortisol levels in the same fashion as ephedrine does?
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03-24-2009, 05:51 AM #8
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03-24-2009, 10:19 AM #9
Pardon the noob question, but what exactly is the mechanism by which clen acts? Are the results solely due to the increase in oxygen?
Thanks
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03-24-2009, 05:14 PM #10
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03-24-2009, 05:59 PM #11
Thanks. I was under the impression that clen was originally meant as a bronchodilator :
"CLENBUTEROL, A b2-AGONIST, is a potent selective bronchodilator
that initially was used as a drug to treat bronchospasm
and to alleviate the symptoms of chronic
obstructive pulmonary disease (COPD) in the horse" which led me to believe that the alleged benefits (at least those regarding thermogenesis) might be the result of better oxygen delivery. Again, thanks for the reply
http://jap.physiology.org/cgi/conten...ract/91/5/2064Last edited by Yolo; 03-24-2009 at 06:04 PM.
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03-24-2009, 06:06 PM #12
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yeah. it's an asthma med. But the improvement in lung function is not related to the fat loss or the muscle gaining. Clen actually seems to reduce muscular endurance with chronic treatment and without the requisite cardio work.
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03-24-2009, 06:59 PM #13
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03-24-2009, 07:02 PM #14
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watch out for that meat we import. animals are on clen for their "leaning" and "toning" effects. lol. i actually prefer my pork with more fatty tissue than muscle.
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03-24-2009, 07:07 PM #15
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i didn't post it, but there is a clinical trial with heart failure patients wherein they use 2 mg of clen ed. I dont' know what the duration was. I'd have to check, but that's an insane dose...
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