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05-08-2011, 03:45 PM #1GameofInchesGuest
Are there any negative health effects to taking Dostinex (cabergoline) for long periods of time? I know it is a dopamine agonist, but will prolonged use make one dependent on it? Thank you!
05-12-2011, 01:55 PM #2
Cabergoline Side Effects
Cabergoline tablets are contraindicated in patients with
- Uncontrolled hypertension or known hypersensitivity to ergot derivatives.
- History of pulmonary, pericardial, cardiac valvular, or retroperitoneal fibrotic disorders .
- There are some medications that are harmful if taken with cabergoline.
- There are particular issues with not prescribing this to women who are pregnant or considering pregnancy.
Cabergoline is not a controlled substance and has not (yet) show to be addictive. The operative work is "yet", consult with your doc before taking this regarding any addiction or withdrawal potential in your particular case.
05-12-2011, 07:21 PM #3GameofInchesGuest
05-14-2011, 02:51 PM #4
05-14-2011, 06:37 PM #5GameofInchesGuest
That's interesting to know, thanks for the info Doc!
07-13-2011, 01:43 PM #6
how is it used with parkinson's patients? ..or is it? Parkinson's runs in my family and I want to know if use of this would induce parkinson's at an earlier age. Thanks in advance for any info on this.
07-20-2011, 10:59 AM #7
08-20-2011, 10:57 AM #8
I just got a script for this myself to help with hyperprolactinemia. Taken 2x a week for 4 months to supress prolactin and then indirectly allow my T levels to come back up (I hope!)
Started yesterday.Training & Diet Blog:
09-24-2011, 10:47 AM #9
1 month results
After one month on cabergoline (1 dose every monday and friday) my prolactin levels went from 23 (high) to 3 (very low). I had no side effects at all during this one month of use. Sadly the suppressed prolactin did not bring up my T levels as was the goal. I went from 517 total to 492 total T in one month. My doc is supposed to be contacting me to decide what we do from this point on.
Since April to now my T went from 535 to the 492 which is a 9% drop in less then 1 year at age 27. He does not like the rate of drop in total T more then anything. We corrected for diet, sleep, training, supplements, stress etc to assure it was not any of those factors causing the drop. It seems to be purely physiological/endocrine based at this time.Training & Diet Blog:
09-24-2011, 11:20 AM #10
09-25-2011, 02:36 PM #11
True but not true...
Total T has diurnal variations yes. Peaking in the early morning and hitting its low point just before bedtime in adult men.
The flux is around 710 ng/dl (peak) and 426ng/dl (low) when measured at 8am and 10pm in a group of 45 men ages 30-35 years. (Archives of Family Medicine 1999; 8)
I had my labs taken at around 8am in fasted state for each of 3 blood draws. Thus to have dropped 9% under the same sample conditions in 9 months at my age and with my lifestyle does not fit well with what my doctor expects to see, nor I for that matter.
Not mention that my peak values are now closer to the daily low most adult men have (compared to this study) which means my true 24 hour low could be around 300 ng/dl if that.
Certainly reason for some concerns at my age and lifestyle. Nor do I use any kind of AAS or have I.Training & Diet Blog:
10-01-2011, 06:12 PM #12
Clomid is a fertility drug, used to stimulate FSH and LH production and hereby the ovaries to produce eggs in ovarian disorders.
10-01-2011, 10:56 PM #13
10-02-2011, 11:18 PM #14
The numbers are what they are and I feel without question my doctor is working in my best interest. I do not want to go on any HRT at all. Not at my age now. Doing so means the likely outcome of a lifetime on them based on his predictions. I will do all I can to stay off HRT as well.
As of now it looks like were going 3 more months Cabergoline since it did drop my levels of prolactin from 23 to 3 in 1 month. The fastest drop he has seen with the drug in that time. With more time this should lift the suppressive effects on T and all is well after that.Training & Diet Blog:
10-03-2011, 07:06 PM #15
10-06-2011, 12:58 AM #16
10-09-2011, 10:00 AM #17
10-12-2011, 02:04 PM #18
10-19-2011, 06:44 PM #19
Why the interest in Cabergoline?
Cabergoline will decrease prolactin levels. Since prolactin is secreted post orgasm, it inhibits a second orgasm from happening until the refractory period is over. If you lower prolactin, the refractory period between orgasms is decreased.
11-28-2011, 10:55 AM #20
1st Test Pre-Dostinex (Caber)
2nd Test 4 months Post-Dostinex (Caber)
So as we see here my prolactin levels did in fact drop down to the levels we wanted them to. A good thing of course. I was at 23ng/ml and not am under 3ng/ml. The drug worked well in that I got these outcomes in just under 5 months.
The REALLY shitty part is that my T levels both total and free have dropped BIG time in the same 5 months.
As you can see I went from 517ng/dl to 260ng/dl with both tests taken at the same lab, same time of day under the same fasted conditions. No differences in diet, cardio or training has taken place between tests either to confound the outcomes I can think of.
I have a follow up with my doc to discuss these numbers and our game plan on the 5th of Dec. I am curious as hell to learn his suggestions since the drug worked by my T also dropped which was the opposite effect we wanted from lowering Prolactin levels....?
I should note my libido has been shit the past 3 weeks or so as well which is not normal for me at all to put it simply.
This is really upsetting for a guy busting ass to gain even a little muscle each year. As an ecto don't I have it hard enough!!??
Last edited by Joshua H; 11-28-2011 at 10:57 AM.Training & Diet Blog:
12-06-2011, 12:46 AM #21
Today after a good long talk with my doctor we decided that Clomid would be an option suitable for my situation. However the possible side effects (nausea when taken, possible burnout due to leydig cell overstimulation and downregulation) did make it a less attractive option. That said he advised (with an endocrinologist consult) that starting me on test-cyp would be the best bet. We decided to go 300mg 1x per week for 3 weeks. We will retest in 8 weeks to see where my labs are then in hopes that my T levels are around 500-600 range or even a bit higher.
So as of today I had to make a big decision since I have not ever, prior to today never taken anything even close to a prohormone let alone full blown T injections.
I think any healthy, active 27 year old make who works as a strength and conditioning specialist with a T level of 260ng/dl would be willing and eager to get on a therapeutic dosing protocol as that's just damn well sad levels if you ask me.Training & Diet Blog:
12-06-2011, 12:56 AM #22
12-06-2011, 01:31 AM #23
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So what's the point of this drug. To lower gyno and you can cum more often?
12-06-2011, 02:46 AM #24
12-07-2011, 11:23 AM #25
I am pushing through a nasty ass head cold right now so any benefits now are being masked by a head full of mucus and a throat raw to the bone plus a mildly suppressed immune system. Been 48 hours since the first dose as of this writing so will see where things go here on out.Training & Diet Blog:
01-09-2012, 07:37 PM #26
T Levels Make it Worth it?
So I got my first 2 T injections (enathate) at 300mg each. One Dec 5th and one Dec 20th. My levels just prior to this were 260ng/dl for total T. Pretty damn low yes.
I went back in on Friday for follow up to these 2 injections to see where I was at and how I was responding. My weight had stabilized but not gone up much from the 192 I was at just prior to HRT started. My levels now are 216ng/dl. Mind you my SHBG is right where it was both times so no changes there. % free T is the same but total has dropped (it also dropped from 532 to 460 to 260 in 6 months time with little change in sleep, diet or training). So this leads me to my purpose in this post.
My doc is going to put me at 400mg every 3 weeks as of tomorrow in hopes this gets the levels up. My concern is weather or not I should still be training balls out with T levels in the freaking low 200's at 27 years old and healthy!?
I lift 4 days a week powerlifter like for about 90 minutes. I do 3 HIIT sessions for 25 minutes on my rest days. I eat no less then 3000 calories a day even on rest days or even when super busy at work. I push for 4000 most days I can feasible find the time to do so. I sleep 7-8 hours a night with maybe 1 night less then 6 hours pending work needs.
I rarely drink, dont smoke, dont do drugs, never did pro hormones etc.
I am prepping for my 2nd ever powerlifting meet on Feb 4th right now and so far so good with my maxes going up week to week but my weight is struggling like hell to hold at 195 (used to be right around 205ish back in spring 2010)
Would it be better to just back off a bit or drop to 3 workouts a week? Drop out cardio? Can you even build any real muscle with T levels around 200ng/dl?
Thoughts?Training & Diet Blog:
01-09-2012, 07:48 PM #27
Your doctor is a retard. By the time you take your bloodwork there is no testosterone left in you. Tell him he needs to dose you weekly, ideally twice a week with cypionate. Unless he wants to ruin your life.
01-09-2012, 07:50 PM #28
You seriously need to tell him to read on hrt. He's gonna fuck you up with injections 15 days apart.
01-09-2012, 08:12 PM #29
So you're saying you are getting cyp injections every 3 weeks? That's retarded. 2 weeks at the maximum. Your levels are fluctuating, that's probably why you keep testing low. I would imaging you are getting blood drawn right at the end of the three weeks? That would make perfect sense that your levels are coming back low. At 100/week you should come back somewhere in the normal range. Maybe low, but still normal. Try to get your doc to do at least biweekly injections. He should understand that cypionate has a half life of I believe about 16 days...don't quote me on that, but its much shorter than three weeks.
01-09-2012, 09:01 PM #30
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Since this is a dopamine agonist, would it have adverse sides in someone with mild tourette's?
01-09-2012, 09:08 PM #31
01-09-2012, 09:18 PM #32
No he's currently on eow injects. 15 days in between. Still, bloods would show drastic changes if he didn't get checked when there was 0 exogenous test in him.
01-09-2012, 09:25 PM #33
01-10-2012, 05:04 PM #34
Sorry gang my mistake. I got 1 injection November 21st at 300mg, then the 5th at 300mg and then the 20th at 300mg. So 2 weeks, then 3 weeks spacing from injection to injection. Today being my 3rd one. Today was 400mg however. I note its not cypionoate I am getting. Its enathate I have been getting.
If this does not bring them up at my next lab reading I am asking to see a specialist ASAP. In fact I meet with my doc face to face again on the 30th so will see what he says then I guess?Training & Diet Blog:
01-10-2012, 05:24 PM #35