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Thread: Clenbuterol - Lots of Great Info
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05-15-2011, 07:58 PM #1
Clenbuterol - Lots of Great Info
This is the updated version found on www.anabolicextreme.com Back issue 70
What is Clenbuterol?
Clenbuterol is a beta-2 agonist and is used in many countries as a broncodilator
for the treatment of asthma. Because of it's long half life, Clenbuterol is not
FDA approved for medical use. It is a central nervous system stimulant and acts
like adrenaline. It shares many of the same side effects as other central nervous system stimulants
like ephedrine. Contrary to por belief, Clenbuterol has a half life of 35
hours and not 48 hours.
Dosing and Cycling
Clenbuterol comes in 20mcg tablets, although it is also available in syrup, pump
and injectable form. It's also available as a powder in some areas. Doses are
very dependent on how well the user responds to the side effects, but somewhere
in the range of 4-8 tablets per day for men and 2-4 tablets a day for women is
most common. Clenbuterol loses its thermogenic effects after around 8 weeks when
body temperature drops back to normal. Its anabolic/anti-catabolic properties
fade away at around the 18 day mark. Taking the long half life into
consideration, the most effective way of cycling Clenbuterol is 2 weeks on/ 2 weeks off
for no more than 12 weeks. ephedrine or Yohimbine can be used in the off weeks.
Clenbuterol vs ephedrine vs dnp - dinitrophenol -
ephedrine will raise metabolic levels by about 2-3 percent and 200mg of dnp - dinitrophenol -
raises metabolic levels by about 30 percent. Clenbuterol raises metabolic levels
about 10 percent and it can raise body temperature several degrees.
dnp - dinitrophenol - is by far the most effective fat burner but many people will never use it
because of the risks associated with it. It also offers no anti-catabolic
benefit. Although it does have anti-catabolic effect, ephedrine's short
half-life prevents it from being all that effective.
As far as side effects, Clenbuterol's are certainly milder than dnp - dinitrophenol - 's, and some
would even say milder than an eca - ephedrine - caffeine - aspirin stack. There is no eca - ephedrine - caffeine - aspirin-style crash on
Clenbuterol and many users find it easier on the prostate and sex drive. This
may in part be due to the fact that Clenbuterol is generally used for only 2 weeks at a
time.
Side effects
NAUSEA
NERVOUSNESS
DIZZINESS
DROWSINESS
DRY MOUTH
FACIAL FLUSHING
HEADACHE
HEARTBURN
INCREASED BLOOD PRESSURE
INCREASED SWEATING
INSOMNIA
LIGHTHEADEDNESS
MUSCLE CRAMPS
TREMORS
VOMITING
CHEST PAIN
The most significant side effects are muscle cramps, nervousness, headaches, and
increased blood pressure.
Muscle cramps can be avoided by drinking 1.5-2 gallons of water and consuming
bananas and oranges or supplementing with potassium tablets at 200-400mg a
day taken before bed on an empty stomach. Taurine at 3-5grams is a necessity in
minimizing cramps.
Headaches can easily be avoided with Tylenol Extra Strength taking at the first
signs of a headache.
Common Uses
post-cycle Therapy: Clenbuterol is used post cycle to aid in recovery. It allows the
user to continue eating large amounts of food, without worrying about adding
body fat. It also helps the user maintain more of his strength as well as his
intensity in the gym. Diet: Roughly the same as on cycle.
Fat loss: The most por use for Clenbuterol, it also increases muscle hardness,
vascularity, strength and size on a caloric deficit. For the most significant
fat loss, Clenbuterol can be stacked with T3. Diet: A high Protein(1.5g per lb of
bodyweight), moderate carb(0.5g to 1g per lb of bodyweight), low fat diet(0.25g
per lb of bodyweight) seems to work best with Clenbuterol.
Alternative to Steroids: Clenbuterol has mild steroid-like properties and can be
used by non-AS using bodybuilder to increase LBM as well as strength and muscle
hardness. Diet: A moderate carb, high Protein, moderate fat diet work well.
Stimulant/Performance Enhancement: It can be used as a stimulant, but an eca - ephedrine - caffeine - aspirin
stack may be a better choice because of it's much shorter half-life. Diet: To
take full advantage of the stimulatory effects of Clenbuterol, carbohydrates must be
included in the diet. Ketogenic diets do not work well in this case.
Precautions: Is Clenbuterol for you?
The same precautions that apply to ephedrine must be applied to Clenbuterol, although
some people find eca - ephedrine - caffeine - aspirin stacks are harsher than Clenbuterol. It should not be stacked
with other central nervous system stimulants such as ephedrine and Yohimbine. These combinations
are unnecessary and potentially dangerous. Caffeine can be used in moderation
before a workout for an extra quick. burst of energy.
A word on Ketotifen
Ketotifen is safe antihistamine used extensively some European countries to
treat asthma and allergies. It can up regulate beta-2-receptors that Clenbuterol down
regulates. Basically, it allows users to extend their use of Clenbuterol for 6-8 weeks
at a time. 2-3mg a day is ideal, 10mg as found in "superclen" can make users
extremely drowsy. It also increases the effectiveness of Clenbuterol so doses must be
adjusted accordingly. The downfall of this drug is its ability to induce
extreme hunger is some people, which is not a desirable state to be in when
dieting.
Cycling Clenbuterol
Most users that report bad side effects and discontinue use are those who use
high doses right at the start of the cycle. The worst side effects occur within
the first 3-4 days of use.
A first time user should not exceed 40mcg the first day. Increase by one tab
until the side effects are not tolerable
Example of a first cycle:
Day1: 20mcg
Day2: 40mcg
Day3: 60mcg
Day4: 80mcg
Day5: 80mcg(Note: Increase the dose only when the side effects are tolerable)
Day6-Day12: 100mcg
Day13: 80 mcg (Tapering is not necessary, but it helps some users get back to
normal gradually)
Day14: 60 mcgs
Day15: off
Day16: off
Day 17: eca - ephedrine - caffeine - aspirin/ NYC stack
Example of a second cycle:
Day1: 60mcg
Day2: 80mcg
Day3: 80mcg
Day4: 100mcg
Day5: 100mcg
Day6-Day12: 120mcg
Day13: 100 mcg
Day14: 80 mcgs
Day15: off
Day16: off
Day 17: eca - ephedrine - caffeine - aspirin/ NYC stack
What else do I need to know?
Taurine MUST be used with Clenbuterol at 3-5g daily. Clenbuterol depletes taurine
levels in the Liver which stops the conversion of T4 to T3 in the Liver.
Taurine allows the user to avoid the dreaded rebound effect and painful muscle
cramps. It's a must with Clenbuterol.
Clenbuterol should not be taken too close to a workout. It can interfere with
your breathing and complete ruin your workout. When doing cardio, it's
advisable to stay at a consistent pace and avoid HIIT style routines.
Do not take Clenbuterol Past 4pm and drink plenty of water; 1.5-2 gallons a day.
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Clenbuterol is anabolic in humans
by Anthony Roberts
Back in 2004 I wrote the first heavily researched article of my career. It was about Clenbuterol, and you can still find it in article forums and profile sections on most major sites. One of the most controversial points I made was that Clenbuterol is anabolic. At the time there was a pretty reasonable amount of animal data (rodents, horses, etc…) and I was fairly confidant saying that Clen has anabolic – or at least strongly anti-cabtabolic – effects in humans. Back when I wrote that article, and my subsequent book(s), there was no published medical data on the accrual of fat free mass in humans using Clenbuterol. And frankly, most bodybuilders who used the stuff were also using a lot of other stuff too.
Naturally, because there was no human data to support this notion, online steroid”experts” rallied behind the notion that because there was no human data proving otherwise, Clen must not have that effect outside of animals. Anyway, a couple of studies have recently popped up in the US National Library of Medicine, that are new or were previously unavailable or unpublished. One is from all the way back in 1993, and was conducted in the UK, and seems to indicate that Clen helped patients regain muscle strength more quickly after orthopedic surgery:
Clin Sci (Lond). 1993 Jun;84(6):651-4.
Clenbuterol, a beta-adrenoceptor agonist, increases relative muscle strength in orthopaedic patients.
Maltin CA, Delday MI, Watson JS, Heys SD, Nevison IM, Ritchie IK, Gibson PH.
Rowett Research Institute, Bucksburn, Aberdeen, U.K.
Abstract
1. The sympathomimetic agent clenbuterol has a muscle-specific anabolic effect in normal and wasted muscles from animals. This trial was designed to examine the effect of the drug on the recovery of muscle strength and area after open medial meniscectomy. 2. A double-blind, completely randomized, placebo-controlled study was carried out on 20 healthy male patients. Muscle strength and cross-sectional area were determined before and after surgery. Patients were treated with drug or placebo for 4 weeks postoperatively and there was a 2 week washout period. 3. The results suggest that, in the operated leg, clenbuterol treatment is associated with a more rapid rehabilitation of strength in knee extensor muscles; in the unoperated leg, knee extensor strength increased above the initial values after 6 weeks (P = 0.01). However, in terms of absolute strength the differences were not significant between the two groups. 4. It is concluded that the data lend support to the proposition that clenbuterol has therapeutic potential in the treatment of muscle-wasting conditions.
In this next study, patients with chronic heart failure were given Clenbuterol, and made some decent gains in muscle size & strength, as well as their lean mass to fat mass ratio:
J Heart Lung Transplant. 2008 Apr;27(4):457-61.
Clenbuterol increases lean muscle mass but not endurance in patients with chronic heart failure.
Kamalakkannan G, Petrilli CM, George I, LaManca J, McLaughlin BT, Shane E, Mancini DM, Maybaum S.
Division of Cardiology, Department of Medicine, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, New York, USA.
Abstract
Clenbuterol, a beta(2)-agonist with potent anabolic properties, has been shown to improve skeletal muscle function in healthy subjects, and in high doses, promotes cardiac recovery in patients with left ventricular assist devices. In a small, randomized controlled study, we investigated the effect of clenbuterol on skeletal muscle function, cardiac function, and exercise capacity in patients with chronic heart failure. Clenbuterol was well tolerated and led to a significant increase in both lean mass and the lean/fat ratio. Maximal strength increased significantly with both clenbuterol (27%) and placebo (14%); however, endurance and exercise duration decreased after clenbuterol. Prior data support combining exercise training with clenbuterol to maximize performance, and on-going studies will evaluate this approach.
Anyway, the point here is that human data is beginning to filter in, albeit in a rehab/post-operative scenario, showing that Clenbuterol does in fact have an anabolic effect in humans.
Clenbuterol is anabolic in humans
by Anthony Roberts
Back in 2004 I wrote the first heavily researched article of my career. It was about Clenbuterol, and you can still find it in article forums and profile sections on most major sites. One of the most controversial points I made was that Clenbuterol is anabolic. At the time there was a pretty reasonable amount of animal data (rodents, horses, etc…) and I was fairly confidant saying that Clen has anabolic – or at least strongly anti-cabtabolic – effects in humans. Back when I wrote that article, and my subsequent book(s), there was no published medical data on the accrual of fat free mass in humans using Clenbuterol. And frankly, most bodybuilders who used the stuff were also using a lot of other stuff too.
Naturally, because there was no human data to support this notion, online steroid”experts” rallied behind the notion that because there was no human data proving otherwise, Clen must not have that effect outside of animals. Anyway, a couple of studies have recently popped up in the US National Library of Medicine, that are new or were previously unavailable or unpublished. One is from all the way back in 1993, and was conducted in the UK, and seems to indicate that Clen helped patients regain muscle strength more quickly after orthopedic surgery:
Clin Sci (Lond). 1993 Jun;84(6):651-4.
Clenbuterol, a beta-adrenoceptor agonist, increases relative muscle strength in orthopaedic patients.
Maltin CA, Delday MI, Watson JS, Heys SD, Nevison IM, Ritchie IK, Gibson PH.
Rowett Research Institute, Bucksburn, Aberdeen, U.K.
Abstract
1. The sympathomimetic agent clenbuterol has a muscle-specific anabolic effect in normal and wasted muscles from animals. This trial was designed to examine the effect of the drug on the recovery of muscle strength and area after open medial meniscectomy. 2. A double-blind, completely randomized, placebo-controlled study was carried out on 20 healthy male patients. Muscle strength and cross-sectional area were determined before and after surgery. Patients were treated with drug or placebo for 4 weeks postoperatively and there was a 2 week washout period. 3. The results suggest that, in the operated leg, clenbuterol treatment is associated with a more rapid rehabilitation of strength in knee extensor muscles; in the unoperated leg, knee extensor strength increased above the initial values after 6 weeks (P = 0.01). However, in terms of absolute strength the differences were not significant between the two groups. 4. It is concluded that the data lend support to the proposition that clenbuterol has therapeutic potential in the treatment of muscle-wasting conditions.
In this next study, patients with chronic heart failure were given Clenbuterol, and made some decent gains in muscle size & strength, as well as their lean mass to fat mass ratio:
J Heart Lung Transplant. 2008 Apr;27(4):457-61.
Clenbuterol increases lean muscle mass but not endurance in patients with chronic heart failure.
Kamalakkannan G, Petrilli CM, George I, LaManca J, McLaughlin BT, Shane E, Mancini DM, Maybaum S.
Division of Cardiology, Department of Medicine, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, New York, USA.
Abstract
Clenbuterol, a beta(2)-agonist with potent anabolic properties, has been shown to improve skeletal muscle function in healthy subjects, and in high doses, promotes cardiac recovery in patients with left ventricular assist devices. In a small, randomized controlled study, we investigated the effect of clenbuterol on skeletal muscle function, cardiac function, and exercise capacity in patients with chronic heart failure. Clenbuterol was well tolerated and led to a significant increase in both lean mass and the lean/fat ratio. Maximal strength increased significantly with both clenbuterol (27%) and placebo (14%); however, endurance and exercise duration decreased after clenbuterol. Prior data support combining exercise training with clenbuterol to maximize performance, and on-going studies will evaluate this approach.
Anyway, the point here is that human data is beginning to filter in, albeit in a rehab/post-operative scenario, showing that Clenbuterol does in fact have an anabolic effect in humans.
Clenbuterol is anabolic in humans
by Anthony Roberts
Back in 2004 I wrote the first heavily researched article of my career. It was about Clenbuterol, and you can still find it in article forums and profile sections on most major sites. One of the most controversial points I made was that Clenbuterol is anabolic. At the time there was a pretty reasonable amount of animal data (rodents, horses, etc…) and I was fairly confidant saying that Clen has anabolic – or at least strongly anti-cabtabolic – effects in humans. Back when I wrote that article, and my subsequent book(s), there was no published medical data on the accrual of fat free mass in humans using Clenbuterol. And frankly, most bodybuilders who used the stuff were also using a lot of other stuff too.
Naturally, because there was no human data to support this notion, online steroid”experts” rallied behind the notion that because there was no human data proving otherwise, Clen must not have that effect outside of animals. Anyway, a couple of studies have recently popped up in the US National Library of Medicine, that are new or were previously unavailable or unpublished. One is from all the way back in 1993, and was conducted in the UK, and seems to indicate that Clen helped patients regain muscle strength more quickly after orthopedic surgery:
Clin Sci (Lond). 1993 Jun;84(6):651-4.
Clenbuterol, a beta-adrenoceptor agonist, increases relative muscle strength in orthopaedic patients.
Maltin CA, Delday MI, Watson JS, Heys SD, Nevison IM, Ritchie IK, Gibson PH.
Rowett Research Institute, Bucksburn, Aberdeen, U.K.
Abstract
1. The sympathomimetic agent clenbuterol has a muscle-specific anabolic effect in normal and wasted muscles from animals. This trial was designed to examine the effect of the drug on the recovery of muscle strength and area after open medial meniscectomy. 2. A double-blind, completely randomized, placebo-controlled study was carried out on 20 healthy male patients. Muscle strength and cross-sectional area were determined before and after surgery. Patients were treated with drug or placebo for 4 weeks postoperatively and there was a 2 week washout period. 3. The results suggest that, in the operated leg, clenbuterol treatment is associated with a more rapid rehabilitation of strength in knee extensor muscles; in the unoperated leg, knee extensor strength increased above the initial values after 6 weeks (P = 0.01). However, in terms of absolute strength the differences were not significant between the two groups. 4. It is concluded that the data lend support to the proposition that clenbuterol has therapeutic potential in the treatment of muscle-wasting conditions.
In this next study, patients with chronic heart failure were given Clenbuterol, and made some decent gains in muscle size & strength, as well as their lean mass to fat mass ratio:
J Heart Lung Transplant. 2008 Apr;27(4):457-61.
Clenbuterol increases lean muscle mass but not endurance in patients with chronic heart failure.
Kamalakkannan G, Petrilli CM, George I, LaManca J, McLaughlin BT, Shane E, Mancini DM, Maybaum S.
Division of Cardiology, Department of Medicine, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, New York, USA.
Abstract
Clenbuterol, a beta(2)-agonist with potent anabolic properties, has been shown to improve skeletal muscle function in healthy subjects, and in high doses, promotes cardiac recovery in patients with left ventricular assist devices. In a small, randomized controlled study, we investigated the effect of clenbuterol on skeletal muscle function, cardiac function, and exercise capacity in patients with chronic heart failure. Clenbuterol was well tolerated and led to a significant increase in both lean mass and the lean/fat ratio. Maximal strength increased significantly with both clenbuterol (27%) and placebo (14%); however, endurance and exercise duration decreased after clenbuterol. Prior data support combining exercise training with clenbuterol to maximize performance, and on-going studies will evaluate this approach.
Anyway, the point here is that human data is beginning to filter in, albeit in a rehab/post-operative scenario, showing that Clenbuterol does in fact have an anabolic effect in humans.
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05-15-2011, 08:12 PM #2
as usual... quality info coming from the Sas!
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05-15-2011, 08:55 PM #3
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05-15-2011, 09:02 PM #4
you know.... I LOVE DRUGS AND CHICKS!
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05-15-2011, 10:25 PM #5
I just LOVE clen!
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05-15-2011, 10:54 PM #6
Lol I'll be asking some 'drug' questions soon, you know you can count on me for stupid chem questions.... Good stuff Sas
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05-15-2011, 11:28 PM #7
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05-15-2011, 11:36 PM #8
dave recommends based on an average. this is a simple way to avoid potential sensitivity at lower doses.
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05-16-2011, 12:34 AM #9
Perfect example of an inexact science. People have been recommending 2 days on / 2 off, 2 weeks on / 2 off, or constant dosing over a long period of time for years. Of these, I'd probably say the 2 days on / 2 off won't do much because clen doesn't clear receptors in 2 days, so you're never really taking a break. Both of the other methods "work". You can pick which ever you want to try and see how it works for you. If you want to run longer than 2 week cycles, then I'd recommend you include ketitofen in your stack. In all cases I'd recommend you include l-taurine at 3-5 g/day to help deal w/ the inhibition of taurine in your system as a result of the clen cycle, to reduce / avoid cramps. (This is well-documented.)
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05-16-2011, 10:46 AM #10
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Ive heard of the 2wks on / off....
Also heard about... taking 2 pills per day and increase by one pill every 2 weeks until 5-6 are reached, then decrease by one pill per week until you are off.
Sassy....for women...who wants to run winny depot plus clen....would you advise it...or should you rather do clen & t-3 ?
Thanks....Keep owning everyone haha!!!=)
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05-16-2011, 12:44 PM #11
Yea... see if you post one bit of information, there's a hundred different interpretations.
- dosing - use 20mcg as your base unit. Start at 20 mcg for first day AM. If its ok, then do 20 mcg first day, later in the afternoon, but generally before 3 pm so you can sleep. If bad sides, back off. If no issue the next day, the either stay at 20 mcg or add 20 mcg, and continue this as you can handle it. No need to push it. Also once you hit 100 mcg, really no reason to go above that, regardless of whether you "feel it" or not.
- you dont' need to taper off. Just stop and let your receptors clear.
- use ketotifen.
RE: winny - recommend you start a different thread.
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05-16-2011, 01:08 PM #12
so after 8 weeks, due to the thermongenic cessation, an endurance athlete could benefit?
Zappatista
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05-23-2011, 07:44 AM #13
I took clen once. I cramped up so bad I didn't dare continue with it.
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01-04-2014, 11:44 AM #14
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Awesome info!!
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01-04-2014, 12:21 PM #15
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