Ostarine...

[tankygirl]

After watching my husband have some amazing fat loss and muscle gain using Ostarine I have just started taking it... 12mg (1/2 mil) a day first thing in the morning...... any other ladies tried it?

[tammyp]

NEVER heard of it...

[booze]

After watching my husband have some amazing fat loss and muscle gain using Ostarine I have just started taking it... 12mg (1/2 mil) a day first thing in the morning...... any other ladies tried it?

Are there any sides for women? I have heard it causes mild shut down for men but not sure of sides for women. And what peptide company you buy through?! Keep us posted!!

[sassy69]

A little more detail always helps...


Ostarine is labeled as a SARM (selective androgen receptor modulator ). The more common name you've probably heard is S-4. ([ame]http://en.wikipedia.org/wiki/Ostarine[/ame])

Ostarine ((2S)-3-(4-cyanophenoxy)-N-[4-cyano-3-(trifluoromethyl)phenyl]-2-hydroxy-2-methylpropanamide) (also known as GTx-024 and MK-2866) is an investigational selective androgen receptor modulator (SARM) from GTX, Inc for treatment of conditions such as muscle wasting and osteoporosis, formerly under development by Merck & Company.[1]
[edit]Structure

According to a recent paper authored by GTx, "Readers are cautioned to note that the name Ostarine is often mistakenly linked to the chemical structure of [S-4], which is also known as andarine. The chemical structure of Ostarine has not been publicly disclosed."[2] While GTx has not formally disclosed the structure of Ostarine, the chemical composition of Ostarine is revealed in patent databases such the WIPO[3] and discussed by Zhang et al., 2009 in the primary literature.[4] Various SARM chemotypes exist (aryl propionamides, quinolines, quinolinones, bicyclic hydantoins), though aryl propionamides such as Ostarine, Andarine/S-4, and S-23 represent some of the most advanced putative therapeutics under investigation.[5] In terms of atom connectivity, Ostarine differs from Andarine by cyano substitutions on the phenyl rings as it replaces both the nitro and acetamido moieties.
[edit]Clinical trials

In December 2006, GTx completed a 3 month Phase II double-blind, randomized, placebo-controlled clinical trial in 120 subjects (60 elderly men and 60 postmenopausal women). Ostarine treatment resulted in a dose-dependent increase in lean body mass (LBM), with those taking the highest dose of 3 mg per day showing an average LBM increase of 1.4 kg (3.1 lbs) compared to those who received placebo. The Ostarine treatment also resulted in improvement in muscle function (performance) in a 12 stair climb test measuring speed and power. Ostarine had a favorable safety profile, with no serious adverse events reported. Ostarine also exhibited tissue selectivity with beneficial effects on lean body mass and performance and with no apparent change in measurements of serum PSA, sebum production or serum LH.[6]
In October 2008, GTx announced topline results of the Phase II trial evaluating Ostarine in patients with cancer cachexia. The clinical trial enrolled 159 cancer patients (average age of 66 years) with non-small cell lung cancer, colorectal cancer, non-Hodgkin lymphoma, chronic lymphocytic leukemia or breast cancer at 35 sites in the U.S. and Argentina. Participants were randomized to receive placebo, 1 mg or 3 mg oral capsule of Ostarine once daily for 16 weeks. Average reported weight loss prior to entry among all subjects was 8.8%. Subjects were allowed to have standard chemotherapy during the trial. The study met its primary endpoint of absolute change in total lean body mass (muscle) compared to placebo and the secondary endpoint of muscle function (performance). The incidence of serious adverse events, deaths and tumor progression were similar among placebo and the treatment arms. The most common side effects reported among all subjects in the trial were fatigue, anemia, nausea and diarrhea.[6]
GTx and Merck had clinical development plans to evaluate Ostarine for the treatment of muscle loss in patients with COPD and for the treatment of chronic sarcopenia. They had a goal of initiating an Ostarine Phase II COPD clinical trial in the first quarter of 2010 and an Ostarine Phase IIb chronic sarcopenia clinical trial in 2010.[7]
http://upload.wikimedia.org/wikipedi...s_Andarine.TIF
[edit]References

^ James T. Dalton, Duane D. Miller, Donghua Yin, Yali He. Selective androgen receptor modulators and methods of use thereof. US Patent 6569896
^ Mohler ML, Bohl CE, Jones A, et al. (June 2009). "Nonsteroidal selective androgen receptor modulators (SARMs): dissociating the anabolic and androgenic activities of the androgen receptor for therapeutic benefit". J. Med. Chem. 52 (12): 3597–617. doi:10.1021/jm900280m. PMID 19432422.
^ WO application 2008127717, James T. Dalton and Duane D. Miller, "Selective Androgen Receptor Modulators for Treating Diabetes", published Oct 23, 2008, assigned to University of Tennessee Research Foundation, James T. Dalton, and Duane D. Miller
^ Zhang X, Lanter JC, Sui Z (September 2009). "Recent advances in the development of selective androgen receptor modulators". Expert Opin Ther Pat 19 (9): 1239–58. doi:10.1517/13543770902994397. PMID 19505196.
^ Jones A, Chen J, Hwang DJ, Miller DD, Dalton JT (January 2009). "Preclinical characterization of a (S)-N-(4-cyano-3-trifluoromethyl-phenyl)-3-(3-fluoro, 4-chlorophenoxy)-2-hydroxy-2-methyl-propanamide: a selective androgen receptor modulator for hormonal male contraception". Endocrinology 150 (1): 385–95. doi:10.1210/en.2008-0674. PMC 2630904. PMID 18772237.
^ a b http://www.gtxinc.com/Pipeline/Ostar...866.aspx?Sid=4
^ http://www.faqs.org/sec-filings/0911...-INC-DE-_10-Q/

[sassy69]

I know a couple guys who have been experimenting w/ S-4 but don't know much about their experiences.

Here's some more info found via google:

S-4 Profile (don't know anything about the officiality of this site): http://www.sarmsinfo.com/profiles/ostarine.php

Entered Phase III pharma trials as of early 2009. Here's the maker's website: http://www.gtxinc.com/Pipeline/Ostar...866.aspx?Sid=4

Article about treatment of muscle-wasting in cancer patients (men, post-menopausal women) with S-4: http://www.medicalnewstoday.com/releases/225897.php

[tammyp]

so tell me like i am 3 year old.....

[sassy69]

so tell me like i am 3 year old.....

Basically something they have been experimenting w/ to come up w/ a way to treat muscle-wasting diseases w/o the sides of steroids.

[tammyp]

gotcha. ty

[foxbody351w]

After watching my husband have some amazing fat loss and muscle gain using Ostarine I have just started taking it... 12mg (1/2 mil) a day first thing in the morning...... any other ladies tried it?

I would LOVE for you to write up a log and really chart your experience with this!! Ive only heard of one other woman using and she only did a 4 week trial, is this your first AAS/prohormone experience?

How long do you plan on using? At the very least come back when you're done and give your input.

And for Tammy...I was doing a lot of research on SARMS for my hubby. The only negatives Ive heard of from guys was when the dose was too high some slight vision issues(of course women are a totally different issue in regards to performance enhancing) SARMS seems to be too new to see long term sides but most are claiming its free from androgenic sides, and from most Ive heard that Osta is better than the S4, I was definitely looking at it for me lateron down the road.

[tankygirl]

Will keep a log and let you know the outcome... the vision issue seems to be from over dosing and we are both keeping to the recommended dose. Husband is gaining approx 3/4kg a week and all body fat is dropping especially around mid section, not that he had a huge amount before using it.
I have done AAS cycles previously using winny and anavar
I am on anavar as well (10mg ED - tablets).
Would rather not post where it is coming from.
ohhhh and although a male friend and hubby both hats the tastes and shudders from having to hold in their mouth for two mins my female trainer and I enjoy the citrus flavour )) the boys reckon it is because females are used to swollowing other strange tasting stuff LOL
It is weird though as it is kept in the fridge but as soon as you put it under your tongue it feels like a hot drink... weird LOL
No extra hunger from taking it like I had with the GHRP6...

[The Prodigy]

Interesting. I wonder how hard this is to obtain!

[s2h]

ostarine is a androgen receptor agonist...its not non-hormonal as most would think..and there is a risk of virilization in women using it..that can vary depending on the dose...its not something that i would recommend for some females...

[sassy69]

ostarine is a androgen receptor agonist...its not non-hormonal as most would think..and there is a risk of virilization in women using it..that can vary depending on the dose...its not something that i would recommend for some females...

Do you mean you wouldn't recommend it for some females, but you would recommend it for others? And what criteria would differntiate these two groups?

[s2h]

Do you mean you wouldn't recommend it for some females, but you would recommend it for others? And what criteria would differntiate these two groups?

the "some" would be the ones who are willing to run the "risk"...like some fbb's are using drugs like tren etc...its a drug that can "reward" but also has a "risk"..so if your the type that will role the dice then this drug can be for you...if your not that type then its not...

[sassy69]

the "some" would be the ones who are willing to run the "risk"...like some fbb's are using drugs like tren etc...its a drug that can "reward" but also has a "risk"..so if your the type that will role the dice then this drug can be for you...if your not that type then its not...

In other words, you're saying anyone who is willing to risk fiddling w/ their androgen levels, and not those who think this is similar to a "fat burner" that you just pop and it fixes everything.

So really, same position as anyone interested in playing w/ steroids. aka Ain't nuttin for free.

Interestingly, I think you'll find that there are many, and not just FBBs using tren.