Tadalafil amplifies the hormonal response of exercise

[Rawstrength]

J Clin Endocrinol Metab. 2008 Sep;93(9):3510-4. Epub 2008 Jun 17.
The type 5 phosphodiesterase inhibitor tadalafil influences salivary cortisol, testosterone, and dehydroepiandrosterone sulphate responses to maximal exercise in healthy men.

Di Luigi L, Baldari C, Sgrò P, Emerenziani GP, Gallotta MC, Bianchini S, Romanelli F, Pigozzi F, Lenzi A, Guidetti L.
Source

Unit of Endocrinology, Department of Health Sciences, University of Rome Foro Italico, Piazza Lauro de Bosis, 15, 00194 Rome, Italy. [email protected]

Abstract

CONTEXT:

Physical exercise-related stress activates hypothalamus-pituitary-adrenal (HPA) axis; nitric oxide is one of the mediators of the HPA axis response to stress, and phosphodiesterase type 5 inhibitors influences nitric oxide-linked biological activities.
OBJECTIVE:

The objective of the study was to investigate whether a single oral long half-life phosphodiesterase type 5 inhibitor (tadalafil) administration influences the HPA axis response to exercise-related stress.
DESIGN:

This was a double-blind, cross-over trial.
PARTICIPANTS:

Participants included nine healthy male athletes.
INTERVENTIONS:

All subjects performed a maximal exercise test in normoxia, after which they received a single oral administration of tadalafil or placebo. Then after a 2-wk washout period, they were crossed over and repeated the exercise test. Each subject was his own control. Salivary collections, for steroid evaluations [cortisol, dehydroepiandrosterone sulphate (DHEAS), testosterone] and respective ratio calculation (DHEAS to cortisol, testosterone to cortisol, testosterone to DHEAS), were performed before each exercise (Pre-Ex), immediately after (Post-Ex), and at 30 min during recovery.
RESULTS:

As expected, mean salivary cortisol concentration increased immediately after exercise after both tadalafil and placebo (P = 0.014 and P =0.036 vs. Pre-Ex, respectively); however, the cortisol increase was significantly higher after tadalafil administration (P = 0.034 vs. placebo). Furthermore, an increased salivary testosterone after exercise was observed only after tadalafil administration (P = 0.029 vs. Pre-Ex). No effects of either exercise and/or tadalafil administration on salivary DHEAS concentrations were observed. DHEAS to cortisol and testosterone to cortisol ratios significantly decreased after exercise after tadalafil administration (P = 0.037, and P = 0.02 vs. placebo, respectively).
CONCLUSION:

Tadalafil administration amplified the salivary cortisol and testosterone responses to a maximal exercise-related stress in healthy trained humans.

PMID: 18559908

FFT

[Scott Stevenson]

Interesting study. They conclude:

"In conclusion, independently from possible effects on performance
and/or on health, it is possible to argue that tadalafil
influences the salivary cortisol and testosterone concentrations
after physical stress."

Their exercise stress was a graded cycle ergometer test to exhaustion and they DON'T report if there was any effect (or even if the analyzed the data) of the cialis on performance. They don't report the final wattage attained, duration of the test on average - nothing. Thus, they didn't control for the exercise stimulus, or if they did, they didn't make mention of it that I saw.

Unless I'm missing something, this is a huge flaw in their methodology (and doesn't support their conclusion). However, they may have got another study coming out where the main finding is an ergogenic effect of cialis. (Thus, they don't present that here. You gotta pump as many articles out of a study as possible.)

Interesting too is that there was correlation of cortisol and testosterone with post-exercise lactate levels, a measure of metabolic stress, but ONLY under the Cialis condition. They don't mention it, but it suggests to me that there may be a spectrum of responsiveness to the dose of Cialis such that when it is ergogenic (more workload = higher lactate) there is naturally a greater hormonal response.

-Scott

[Rawstrength]

Interesting study. They conclude:

"In conclusion, independently from possible effects on performance
and/or on health, it is possible to argue that tadalafil
influences the salivary cortisol and testosterone concentrations
after physical stress."

Their exercise stress was a graded cycle ergometer test to exhaustion and they DON'T report if there was any effect (or even if the analyzed the data) of the cialis on performance. They don't report the final wattage attained, duration of the test on average - nothing. Thus, they didn't control for the exercise stimulus, or if they did, they didn't make mention of it that I saw.

Unless I'm missing something, this is a huge flaw in their methodology (and doesn't support their conclusion). However, they may have got another study coming out where the main finding is an ergogenic effect of cialis. (Thus, they don't present that here. You gotta pump as many articles out of a study as possible.)

Interesting too is that there was correlation of cortisol and testosterone with post-exercise lactate levels, a measure of metabolic stress, but ONLY under the Cialis condition. They don't mention it, but it suggests to me that there may be a spectrum of responsiveness to the dose of Cialis such that when it is ergogenic (more workload = higher lactate) there is naturally a greater hormonal response.

-Scott

the methodological issues aside, one of the latest studies from Stuart Phillips lab at McMasters

Associations of exercise-induced hormone profiles and gains in strength and hypertrophy in a large cohort after weight training

Communicated by Fausto Baldissera.
Abstract
The purpose of this study was to investigate associations between acute exercise-induced hormone responses and adaptations to high intensity resistance training in a large cohort (n = 56) of young men. Acute post-exercise serum growth hormone (GH), free testosterone (fT), insulin-like growth factor (IGF-1) and cortisol responses were determined following an acute intense leg resistance exercise routine at the midpoint of a 12-week resistance exercise training study. Acute hormonal responses were correlated with gains in lean body mass (LBM), muscle fibre cross-sectional area (CSA) and leg press strength. There were no significant correlations between the exercise-induced elevations (area under the curve&mdash;AUC) of GH, fT and IGF-1 and gains in LBM or leg press strength. Significant correlations were found for cortisol, usually assumed to be a hormone indicative of catabolic drive, AUC with change in LBM (r = 0.29, P < 0.05) and type II fibre CSA (r = 0.35, P < 0.01) as well as GH AUC and gain in fibre area (type I: r = 0.36, P = 0.006; type II: r = 0.28, P = 0.04, but not lean mass). No correlations with strength were observed. We report that the acute exercise-induced systemic hormonal responses of cortisol and GH are weakly correlated with resistance training-induced changes in fibre CSA and LBM (cortisol only), but not with changes in strength.

http://www.springerlink.com/content/228h54586751g19l/

They showed that

1. exercise induced elevations in testosterone do not correlate with increases in any performance / muscle gain variables

And

2. increases in cortisol, on the other hand correlate with increases in type II muscle CSA and over all increases in lean body mass...

So please can we stop with the villification of cortisol and realize that short term / exercise induced elevations in testosterone are 100% irrelevant

[maryjones]

Tadalafil are really good for sexual life.It is a best sex booster medication.It make some hormonal cahnges by regulating a blood supply and make sexual life pleasurable.

[GirlyMuscle]

stereo instructions

That's what I think every time I try to read these scientific things. It's like the Matelands reading their handbook for the newly dead in Beetlejuice.