"Letrozole once a week normalizes serum testosterone in obesity-related male hypogonadism"

[Waylon]

Posted this for another thread but thought others may find this abstract interesting.

"Letrozole once a week normalizes serum testosterone in obesity-related male hypogonadism.

Sandra Loves-European Journal of Endocrinology; May2008, Vol. 158 Issue 5, p741-747, 7p

OBJECTIVE: Isolated hypogonadotropic hypogonadism (IHH) is frequently observed in severely obese men, probably as a result of increased estradiol (E2) production and E2-mediated negative feedback on pituitary LH secretion.Aromataseinhibitors can reverse this process. This study evaluates whether letrozole once a week can normalize serum testosterone in severely obese menand maintain its long term effect.

DESIGN: Open, uncontrolled 6-month pilot study in 12 severely obese men (body mass index>35.0 kg/m2) with obesity-related IHH and free testosterone levels <225 pmol/l, treated with 2.5 mg letrozole once a week for 6 months. RESULTS: Six weeks of treatment reduced total E2from 123±11 to 58±7 pmol/l (P<0.001, mean±S.E.M.), and increased serum LH from 4.4±0.6 to 11.1±1.5 U/l (P<0.001). Total testosterone rose from 5.9±0.5 to 19.6±1.4 nmol/l (P<0.001), and free testosterone from 163±13 to 604±50 pmol/l (P<0.001). Total testosterone rose to within the normal range in all subjects, whereas free testosterone rose to supraphysiological levels in 7 out of 12 men. The testosterone and E2levels were stable throughout the week and during the 6-month treatment period.

CONCLUSION: Letrozole 2.5 mg once a week produced a sustained normalization of serum total testosterone in obese men with IHH. However, free testosterone frequently rose to supraphysiological levels. Therefore, a starting dose <2.5 mg once a week is recommended. [ABSTRACT FROM AUTHOR]"

[Sam Poe]

Interesting, thanks Waylon

[world-pharma]

real interested!