Testosterone and the breast.

**heavyiron** · 09-29-2010, 09:14 PM

Testosterone and the breast.

Shufelt CL, Braunstein GD.
Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
Abstract

Although women have been treated with testosterone (T) for female sexual dysfunction since the 1950s, the role of T in normal female physiology is not yet fully defined. One of the major safety concerns of androgen therapy is whether androgens have a stimulatory effect on the breast that could lead to breast carcinomas. The proposed mechanisms for such stimulation include local estrogen production from the aromatase enzyme complex present in the breast tissue or by the direct stimulation of the androgen receptor. Predominant data from in vitro studies have shown that androgens actually have apoptotic and antiproliferative effects and not stimulatory effects. Animal models have shown similar results to in vitro studies, finding that androgens inhibit breast cancer growth. Prospective and retrospective epidemiological analyses have shown mixed outcomes, with no clear consensus regarding androgen use and breast cancer risk. Hyperandrogenism in patients with polycystic ovarian syndrome with elevated levels of endogenous T is not associated with an increased risk of breast cancer and may, in fact, be protective. Another human model with excess of T is female-to-male transgenderism, in which genotypic women are treated with large doses of exogenous T with no increased risk. High-dose androgen therapy also has been effective in treating patients with advanced breast cancer. Thus, the preponderance of data suggests that T use in females is not associated with an increased risk of breast carcinoma.

PMID: 18714077 [PubMed - indexed for MEDLINE]

**tammyp** · 09-30-2010, 05:27 AM

good to see this..my ob/gyn is concerned my t levels are high based on my muscle mass (lol!) and is concerned with risk factors. i hate drs that dont get out sport.

**s2h** · 09-30-2010, 08:27 AM

Originally Posted by tammyp

good to see this..my ob/gyn is concerned my t levels are high based on my muscle mass (lol!) and is concerned with risk factors. i hate drs that dont get out sport.

i would think he would be more concerned with your estrogen levels....