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01-05-2010, 03:14 PM

Tadalafil Citrate

What Is Cialis (Tadalafil)

Cialis is a brand name for a substance with the chemical name tadalafil. It is used to treat men who experience difficulty having and maintaining an erection to orgasm.

It was first introduced in February 2003 and it was approved by the FDA on November 21, 2003. Cialis was first marketed by Lilly ICOS, a joint venture between Eli Lilly and ICOS Corporation.

The standard starting dose size is 10 milligrams, but some men will find 5 milligrams enough. In some cases a 20 milligram dose is necessary. Cialis should be taken orally 30 minutes or longer before sexual activity.

Medical testing has shown that cialis is effective in 60%-80%, of cases when used to treat erectile dysfunction in men. Most failure cases are from men that have had some form of surgery that made getting or maintaining an erection physically impossible. During PCT a man may find it more difficult to have or maintain an erection so Cialis is a possible solution to that problem.

Cialis produces results similar to viagra, but the effects of cialis last longer than viagra. In addition, cialis can be taken on an empty stomach or with a meal. When Cialis and Viagra were compared in a study Cialis allowed for more sexual frequency and that in turn raised Testosterone levels higher in the Cialis group.

Viagra should not be taken with high fat foods because these foods reduce absorption of viagra in the human body. Cialis on the other hand may be used even when dining on high fat foods, with no decrease in effects.

How Does Cialis Work

Medications like cialis, viagra, and levitra work by inhibiting a chemical called phosphodiesterase type 5. Because of their mode of action, these drugs are commonly referred to simply as PDE5 inhibitors.

When a man gets sexually excited, it triggers cells in the penis to produce nitric oxide. The increase in nitric oxide will in turn cause production of cyclic guanosine monophosphate (cGMP). The cGMP causes arteries in part of the penis to relax and allow more blood to flow through them. The increase in blood flow causes an erection.

If the enzyme phosphodiesterase type 5 (PDE5) is of sufficient quantity, it will attack the cGMP and erection will not be maintained. Cialis and other PDE5 inhibitors reduce the amount of PDE5 available to attack cGMP. With a reduction of PDE5, most men are able to maintain an erection to orgasm.

How Long Do the Effects of Cialis Last

The effects of cialis have been shown to last 24 to 36 hours in a majority of users. The effects of viagra have been shown to last 4 to 6 hours in a majority of users.

Some men like the fact that cialis works for up to 36 hours and allows the user and his partner to relax, forget about planning intimacy and let things happen when the moment is right.

24 to 36 hours might seem ideal but some men report they switched back to viagra because 6 hours or less was what they preferred. I have personally have had good results from Cialis anywhere from 1-36 hours after taking it but 24 hours seems to be a peak time for me.

Taking cialis does not increase sexual desire and it will not give you an erection for 36 hours. Most men who take cialis report that for up to 36 hours after taking cialis, an erection can be sustained when the penis was stimulated by touch. After orgasm, the penis will usually return to its pre-aroused state.

Some men may be able to have one or more orgasms after the first but this an exception. In most cases, within 36 hours of taking 20 milligrams of cialis, you will be able to get and maintain an erection to orgasm one time.

Most men that have had more than one orgasm from a single dose say they had the first orgasm within 60-180 minutes of taking cialis then were able to have one or more orgasms by waiting 60 minutes or longer before any more penis stimulation was attempted. This is something the user will have to experiment with to find out their own particular climax capacity.

01-05-2010, 03:17 PM
Cialis outperforms Viagra in sexual frequency and in raising testosterone.

Type V phosphodiesterase inhibitor treatments for erectile dysfunction increase testosterone levels.

Carosa E (http://forums.rxmuscle.com/pubmed?term=%22Carosa%20E%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsP anel.Pubmed_RVAbstract), Martini P (http://forums.rxmuscle.com/pubmed?term=%22Martini%20P%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsP anel.Pubmed_RVAbstract), Brandetti F (http://forums.rxmuscle.com/pubmed?term=%22Brandetti%20F%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsP anel.Pubmed_RVAbstract), Di Stasi SM (http://forums.rxmuscle.com/pubmed?term=%22Di%20Stasi%20SM%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsP anel.Pubmed_RVAbstract), Lombardo F (http://forums.rxmuscle.com/pubmed?term=%22Lombardo%20F%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsP anel.Pubmed_RVAbstract), Lenzi A (http://forums.rxmuscle.com/pubmed?term=%22Lenzi%20A%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsP anel.Pubmed_RVAbstract), Jannini EA (http://forums.rxmuscle.com/pubmed?term=%22Jannini%20EA%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsP anel.Pubmed_RVAbstract).
Department of Experimental Medicine, University of L'Aquila, L'Aquila, Italy.

OBJECTIVE: Lack of sexual activity due to erectile dysfunction (ED) decreases testosterone (T) levels through a central effect on the hypothalamic-pituitary axis. In this paper we studied the effect of different type V phosphodiesterase (PDE5) inhibitor treatments for ED on the reversibility of this endocrine pattern. DESIGN: Open-label, retrospective study. PATIENTS: Seventy-four consecutive patients were treated on demand with sildenafil (Sild) (50 mg) and tadalafil (Tad) 20 mg. MEASUREMENTS: The success in sexual intercourse was recorded and total (tT) and free testosterone (fT) levels were studied before and after 3 months of treatment. RESULTS: Basal level of tT and fT were at the bottom of the normal range and LH levels were at the top of the high normal range. After treatments, this endocrine pattern was reversed in both groups. However, the T increase in Sild-treated patients was significantly lower than in those treated with Tad (4.7 +/- 2.7 vs. 5.1 +/- 0.9, P < 0.001). fT levels followed a directly proportional pattern, while the inverse was found when LH production was studied. The intercourse rate reflected this effect: in fact, the Sild group showed a 4.9 +/- 2.9/month full sexual intercourse rate while in the Tad group a significantly higher rate of sexual intercourse was found (6.9 +/- 4.6/month, P = 0.04). However, drug consumption was comparable between the groups (Sild 4.9 +/- 2.9 vs. Tad 4.4 +/- 2.8 pills/month, P = 0.72). CONCLUSIONS: As it is unlikely that the two drugs have a different direct effect on the pituitary-testis axis, this effect is probably due to the higher frequency of full sexual intercourse in the Tad-treated group, because of the drug's longer half-life.

PMID: 15355456 [PubMed - indexed for MEDLINE]

01-05-2010, 03:33 PM
Five-year experience with tadalafil in the UK: an effective treatment for erectile dysfunction.

Dinsmore W (http://forums.rxmuscle.com/pubmed?term=%22Dinsmore%20W%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsP anel.Pubmed_RVAbstract).
Royal Victoria Hospital, Grosvenor Road, Belfast, UK. [email protected]

BACKGROUND: Erectile dysfunction (ED) is a common medical condition. In the UK, approximately 2.3 million men suffer from moderate-to-severe ED, many of whom do not consult a healthcare professional about the problem. Phosphodiesterase-type 5 (PDE5) inhibitors have revolutionised treatment for ED and three such drugs are currently available: sildenafil citrate, tadalafil and vardenafil HCl. METHODS: This article reviews available information on the efficacy and safety of tadalafil for the treatment of ED, with a focus on clinical experience in the UK. RESULTS: The clinical effects of tadalafil have been shown to last for up to 36 h after administration, longer than the other PDE5 inhibitors, which are effective for only 4-5 h after dosing. Extensive clinical experience with tadalafil, worldwide and in the UK, supports its efficacy and tolerability in many patient populations, including those with comorbidities often associated with ED. CONCLUSIONS: Studies have shown that tadalafil is an effective ED treatment, regardless of disease severity and cause, patient age and presence of comorbid conditions. As the treatments for ED have evolved, patient preference has emerged as an important aspect of ED therapy.

PMID: 19624790 [PubMed - in process]

01-23-2010, 06:15 PM
A 6-month study of the efficacy and safety of tadalafil in the treatment of erectile dysfunction: a randomised, double-blind, parallel-group, placebo-controlled study in Australian men.

McMahon CG (http://forums.rxmuscle.com/pubmed?term=%22McMahon%20CG%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsP anel.Pubmed_RVAbstract), Stuckey BG (http://forums.rxmuscle.com/pubmed?term=%22Stuckey%20BG%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsP anel.Pubmed_RVAbstract), Lording DW (http://forums.rxmuscle.com/pubmed?term=%22Lording%20DW%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsP anel.Pubmed_RVAbstract), Wittert GA (http://forums.rxmuscle.com/pubmed?term=%22Wittert%20GA%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsP anel.Pubmed_RVAbstract), Murphy A (http://forums.rxmuscle.com/pubmed?term=%22Murphy%20A%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsP anel.Pubmed_RVAbstract), Shin J (http://forums.rxmuscle.com/pubmed?term=%22Shin%20J%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsP anel.Pubmed_RVAbstract), Sutherland PD (http://forums.rxmuscle.com/pubmed?term=%22Sutherland%20PD%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsP anel.Pubmed_RVAbstract), Palmer NR (http://forums.rxmuscle.com/pubmed?term=%22Palmer%20NR%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsP anel.Pubmed_RVAbstract), Lowy MP (http://forums.rxmuscle.com/pubmed?term=%22Lowy%20MP%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsP anel.Pubmed_RVAbstract), Jesudason DR (http://forums.rxmuscle.com/pubmed?term=%22Jesudason%20DR%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsP anel.Pubmed_RVAbstract), Fredlund P (http://forums.rxmuscle.com/pubmed?term=%22Fredlund%20P%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsP anel.Pubmed_RVAbstract).
Australian Centre for Sexual Health, St Leonards, Sydney, New South Wales 2011, Australia. [email protected]

The efficacy and safety of tadalafil for the treatment of erectile dysfunction (ED) were assessed in a 6-month, randomised, double-blind, placebo-controlled study. Australian men with mild, moderate or severe ED of organic, psychogenic or mixed aetiology were randomised to tadalafil 20 mg as needed (n = 93) or placebo (n = 47). Efficacy assessments included the international index of erectile function (IIEF) and the sexual encounter profile (SEP) diary. Tadalafil significantly improved erectile function compared with placebo (p < 0.001, all measures). At the end of the study, the mean per-patient proportion of successful sexual intercourse attempts (SEP question three) was 73.5% for patients treated with tadalafil and 26.8% for placebo-treated patients. Improved erections were reported by 78% of tadalafil-treated patients compared to 12.8% of placebo-treated patients. The most common treatment-emergent adverse events--headache and dyspepsia--were generally mild or moderate. Tadalafil was effective and well tolerated in Australian men with mild to severe ED.

PMID: 15854188 [PubMed - indexed for MEDLINE]

01-23-2010, 09:01 PM
jog my memory is it benadryl that will keep you from getting headaches from cialis?

01-23-2010, 09:06 PM
jog my memory is it benadryl that will keep you from getting headaches from cialis?
I don't know. Cialis does not give me headaches nearly as bad as Viagra though.

08-06-2010, 07:06 AM
Hi, You can try Tadalafil which relaxes muscles in the penis and increases blood flow in it. It helping men to achieve and maintain an erection. Tadalafil is only for men with erectile dysfunction and is not for women.

08-04-2011, 02:00 PM
IMO people used to take much more PDE2 that is really needed.
Tadalafil works well and in much more "natural" effect with only 5mg .
And it does not cause tolerance or dependence.

Ryan Wacht
08-25-2011, 09:00 PM
I don't know. Cialis does not give me headaches nearly as bad as Viagra though.

How much viagra do you usually take? One hundred mgs is the most I can take without getting the headache from hell. Sometimes I even get one at that dose.

Ryan Wacht
09-27-2011, 11:47 AM
jog my memory is it benadryl that will keep you from getting headaches from cialis?

I take 800mg ibuprofen as a precautionary measure sometimes. It's much better then aspirin and acetiminophen in countering headaches.

Of course if you get the classic migraine, nothing works better then imitrex!