View Full Version : Havoc~Methepitostane

01-09-2010, 11:07 AM
Havoc (methepitiostane)

Androgenic 91
Anabolic 1100
Standard Methyltestosterone (oral)
Chemical Name 2alpha,3alpha-epithio-17alpha-methylSalpha-androstan-17beta-ol
Estrogenic Activity none
Progestational Activity none

Methepitiostane is an oral anabolic steroid derived from dihydrotestosterone. This agent is a c17-alpha alkylated analog of epitiostane (see Thioderon), and like this drug also displays a favorable balance between anabolic and androgenic effect. In this case, however, the separation is considerably more pronounced, with the drug exhibiting an anabolic effect that is roughly 12 times more pronounced than its androgenic effect.That is according to the standard animal assays, which often vary somewhat to experiences in humans. This drug was never clinical tested in humans, so what is known of it is based on a small number of animal experiments, and structural and anecdotal observations. What can be stated with certainty if that methepitiostane is a primarily anabolic steroid with a pronounced level of activity, and is effective for the promotion of lean mass and strength gains. It likely also imparts some anti-estrogenic effect, further strengthening the association between this agent and dieting, cutting, and lean muscle mass phases of training as opposed to bulking.

Methepitiostane was first described in 1966, during investigations into a series of A-ring modified androstane derivatives.571 That same year it was assayed for anabolic and androgenic potency via the standard rat assays, and demonstrated both pronounced anabolic properties and very weak relative androgenicity.572 The assay results were probably most similar to desoxymethyltestosterone (Madol), although methepitiostane is about half as androgenic. Although the results of the early testing were very favorable, this agent never progressed to the point of being a commercial steroid product or even tested on human subjects. Like a great many steroids, it was examined but not actualized as a prescription product. For forty years, the agent would be lost to the public, existing as an item of research interest only.
Methepitiostane would emerge from research obscurity at the end of 2006, when a new company called Recomp Performance Nutrition introduced it to the U.S. market under the trade name Havoc. It would be sold openly as a dietary supplement.This channel of sales does not reflect a weak potency or "non-steroid" classification, however, as methepitiostane is very much a potent drug. It is being sold as such due to the fact that the u.s. dietary supplement market is not tightly regulated, and the drug was never classified (specifically according to the law) as an anabolic steroid. While regulations do exist that would prevent the sale of an unapproved new drug as a food supplement, they do not carry the same weight as the anabolic steroid laws, and have historically not been aggressively enforced. Methepitiostane remains on sale as of December 2006, although the manufacturer has stated that they plan to discontinue the product very shortly.

How Supplied:
Methepitiostane was never approved as a prescription drug preparation. It is being sold in the U.S. supplement market under the trade name Havoc, and is supplied in the form of capsules containing 10 mg of steroid.

Structural Characteristics:
Methepitiostane is a modified form of dihydrotestosterone. It differs by 1) the addition of a 17alpha methyl group, which helps protect the steroid from metabolism during oral administration, and 2) the replacement of 3-keto with 2,3 alpha-epithio, which increases anabolic strength while reducing relative androgenicity.

Administration (Men):
Methepitiostane was never approved for use in humans., Prescribing guidelines are unavailable. An effective dosage for physique-or performance-enhancing purposes falls in the range of 10-20 mg daily.This is usually taken for no longer than 6-8 weeks, in an effort to avoid significant liver strain. At this level the drug should impart a measurable but moderate lean-mass-building effect, which, depending on dietary and metabolic factors, may be accompanied by measurable fat loss and an increase in! definition. Doses of 30 mg per day are also commonly used, however given the high relative potency of the steroid may present significant hepatotoxicity. When administered, higher doses are usually taken for durations lasting no longer than 4-6 weeks.
Administration (Women):
Methepitiostane was never approved for use in humans. Prescribing guidelines are unavailable. An effective dosage for physique-or performance-enhancing purposes would be around 5 mg per day. This would be taken for no longer than 4-6 weeks, in an effort to avoid significant liver strain or virilizing side effects. Given that complete separation of anabolic and androgenic effect has not been achieved with any steroid, this agent is still capable of producing virilizing activity given the right dose or individual sensitivity.

Llewellyn’s W. (2009). Anabolics (9th ed), Havoc methepitiostane (pp. 267-269): Jupiter, FL: Molecular Nutrition

10-30-2010, 04:32 PM
Methylepitiostanol (Epistane)


Methylepitiostanol is a methylated version of the steroid Epitiostanol. It is readily active and does not require conversion. Under the influence of heat methylepitiostanol readily breaks down to 17a-Methyl-androstan-2-en-17b-ol (DMT), a now illegal anabolic steroid.

It does not aromatize, however it is possible that methylepitiostanol may offset estrogen and testosterone from SHBG thus increase the risk of gyno for certain individuals with high SHBG levels. Gyno symptoms from this compound may also be a result of this compounds inability to form a potent androgen such as DHT (to antagonize the effects of estrogen). However, in other cases methylepitiostanol can be used to prevent or reduce gynecomastia from an estrogenic steroid by acting as an aromatase inhibitor to keep estrogen down.

It is a DHT derivative with a fairly moderate androgenic value so the chances of hair loss may be increased in certain sensitive users. Swelling of the prostate may also become an issue. The powerful estrogen suppressing action of this steroid and its 17aa stucture will cause it to negatively influence the cholesterol profile by lowering HDL and increasing LDL. It has also been reported to cause stiff joints, possibly related to its suppressive effect on estrogen levels.

Anecdotal reports of appetite suppression and general fatigue would lead one to believe that the liver stress from this 17aa compound is rather severe. For this reason it is recommended to use a liver protecting supplement prior to and during the use of this steroid.

Methylepitiostanol has a strong anabolic action that will lead to quick gains in lean muscle mass and strength with very little bloat. The gains will appear with minimal fat gain and increased vascularity.

Because methylepitiostanol can negatively affect joint comfort it is recommended to be stacked with an aromatizing or progestational compound. However, it is not recommended to stack this steroid with another 17aa oral.

Common Clones:

Epistane by Innovative Body Enhancement (IBE)
Havoc by Primaforce
Havoc by Recomp Performance Nutrition (RPN)
Epi-MAX by Anabolic Formulations
M14-E by Purus Labs
Methyl-E by Engineered Sports Technology (EST)
E-Max by Juggernaut Nutrition
E-Stane by Competitive Edge Labs (CEL)
Hemaguno by Spectra Force Research
Hemapolin by Starmark Labs
Epi-Mass by Armour Nutrition
Epidrol by Genera Labs
Methyl Freak by Rockhard Formulations
Epistrong by Mrsupps


“2,3-Epithio-5-androstan-17ß-yl 1-Methoxycyclopentyl Ether in the Treatment of Advanced Breast Cancer —A Preliminary Clinical Trial”
Japanese Journal of Clinical Oncology 4:65-68 (1974)
“Inhibited growth in vivo of a mouse pregnancy-dependent mammary tumor (TPDMT-4) by an antiestrogen, 2alpha, 3alpha-epithio-5alpha-androstan-17beta-ol (10275-S).”
Matsuzawa A, Yamamoto T.Cancer Res. 1976 May;36(5):1598-606.
“Antitumor Effect of Two Oral Steroids, Mepitiostane and Fluoxymesterone, on a Pregnancy-dependent Mouse Mammary Tumor (TPDMT-4)1”
Akio Matsuzawa and Tadashi Yamamoto
Cancer Research 37, 4408-4415, December 1, 1977

By Jason Rowland

Chemical Name(s):

Chemical Formula: C20H30OS
Molecular Weight: 320.5
Q Qatio: 12
Anabolic #: 1,100
Androgenic #: 91
Oral Bioavailability: Estimated at 40%
AR Binding Affinity: NA
SHBG Binding Affinity: NA
Half Life: ~6 hours
Legal Status (US): Not listed as a controlled substance
Average Dose:
40-50mg/day standalone
10-20mg/day when stacked
Average Cycle Length: 4-6 weeks

01-08-2011, 12:40 AM
Love this stuff.

06-09-2012, 10:56 AM
What would a good PCT protocol look like for epistane (say a 4 week cycle), nolva? Clomid? HCG?

06-10-2012, 06:57 PM
A SERM for 4-6 weeks would be fine for PCT.

06-10-2012, 10:33 PM
nice post

06-11-2012, 12:30 PM
Epistane doesn't require a pct in my opinion and experience..Actually, I use it in doses of 40-50mgs IN my pct as it helps keep gains from a much stronger cycle...you're just going to get more sides from SERM therapy than if you just come off epi

10-19-2013, 04:15 PM
Epistane doesn't require a pct in my opinion and experience..Actually, I use it in doses of 40-50mgs IN my pct as it helps keep gains from a much stronger cycle...you're just going to get more sides from SERM therapy than if you just come off epi

What about if you are 60 yo like me?

10-30-2013, 03:58 PM
What about if you are 60 yo like me?

Then you should be on replacement test and gh anyways.

01-15-2014, 07:42 AM
I never tried this PH a buddy of mine did and LOVED it , another buddy tried it and didn't gain much which is why I decided to go with Mdrol , man loved that stuff.

05-18-2014, 08:20 AM
very interested in this as my first time with a PH.... What kind of cycle do you suggest? I am 31 been lifting for 15 years very experienced with diet and exercise no real experience with any PH usage... just looking for 3-6 lbs dry nothing crazy..

05-18-2014, 11:44 AM
I was taking Havoc epistane and noticed it would bloat my midsection? I read that it might be a different but similar compound than epistane?